Longevity genotyping panel


Know the odds of exceptional longevity based on three key genes

Longevity Genotyping is now offered as an additional service to our Telomere Testing Kit. You can order it at our shop. 

Titanovo offers an additional longevity panel which assays the APOE, ACE, and APOC3 genes.

Here we give a general overview of the panel and wellness recommendations that can be extracted from results.

Centenarian odds

Recent gerontology studies are clear about the factors influencing maximal lifespan. While positive lifestyle choices, exercise, and a stress-free life are all linked to improved health and increased longevity, the ability to reach the age of a cenentenarian (100+) seems to be largely (~70%) of genetic nature.

By applying known statistical correlations between different polymorphisms of APOE, ACE, APOC3 – genes that have proven to be the top 3 longevity influencers – we are calculating the relative chances of reaching 100 years in comparison to the general population.

This number is a statistical probability based on only these three genes related to longevity.

ApoE gene results interpretation

The apolipoprotein E (ApoE) gene creates a protein which, when combined with fat, becomes a lipoprotein. The lipoprotein ApoE is a low-density lipoprotein, responsible in part for removing cholesterol from the bloodstream. The long evolutionary history of APOE is deeply connected with historical diet changes and ability to process fats.

We genotype 2 SNPs from the ApoE gene that form 3 possible allels: ε2, ε3, ε4. This forms possible genotypes: ε2/ε2, ε2/ε3, ε3/ε3, ε3/ε4, ε4/ε4, ε2/ε4.

Simple ApoE genotyping provides accesss to diet recommendations for the so-called ApoE diet, which informs patients of the proportion of energy sources that are beneficial for his or her body.

ApoE is one of the most interesting genes in the human body, having many potential points of influence. First of all, it is one of the genes most strongly related to nutritional needs. Having its roots in Mediterranian diets and the separation between southern and northern European populations, this gene helps to predict the optimal Fat/Protein/Carbohydrate proportion that an individual is best adapted to.

ACE gene results interpretation

Angiotensin-converting enzyme, or “ACE,” indirectly increases blood pressure by causing blood vessels to constrict. It does this by converting angiotensin I to angiotensin II. The complicated gene encoding ACE enzyme is located in chromosome 17. We are assaying a key polymorphism in this gene, which is an insertion/deletion SNP rs4340. I/D polymorphism in this region significantly changes the activity of corresponding enzymes, initializing a series of biochemical changes resulting in a variety of general and pathophysiological conditions.

A polymorphism of the angiotensin I-converting enzyme (ACE) gene became the first genetic element shown to impact substantially human physical performance. The renin-angiotensin system (RAS) exists not just as an endocrine regulator, but also within local tissue and cells, where it serves a variety of functions. Functional genetic polymorphic variants have been identified for most components of RAS, of which the best known and studied is a polymorphism of the ACE gene. The ACE insertion/deletion (I/D) polymorphism has been associated with improvements in performance and exercise duration in a variety of populations. The I allele has been consistently demonstrated to be associated with endurance-orientated events, notably, in triathlons. Meanwhile, the D allele is associated with strength and power-orientated performance, and has been found in significant excess among elite swimmers.

http://www.ncbi.nlm.nih.gov/pubmed/21615186 

APOC3 gene results interpretation

Apolipoprotein C-III, also known as apo-CIII, is a protein that in humans is encoded by the APOC3 gene. Apo-CIII is a component of a very low density lipoprotein (VLDL). APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to inhibit hepatic uptake of triglyceride-rich particles. We genotype SNP Rs2542052, which is highly linked with longevity.

Rs2542052 SNP hasn’t been significantly relayed to any medical condition, although it is strongly and significantly linked to longevity. Each C variant adds about 25% percent odds of becoming a centenarian. It was shown that people with a C variant (one or two of them) have lower LDLs, lower triglycerides, lower total cholesterol, and higher HDL levels.

Note: By ordering a longevity genotyping panel you agree that you are not seeking medical advice. This data is strictly with regards to polymorphisms of the genes APOC3, APOE, and ACE. There are many other factors which may affect your actual longevity, which are not considered here. This analysis should be considered interesting statistical information, and is not a medical diagnosis or advice.