The effects of DNA on Weight Management

The effects of DNA on Weight Management

Weight gain over the years is usually a fact of life. As we age, our metabolism slows, and it becomes increasingly difficult to fight off a modest bulge in our bellies. However, the amount of weight gain varies widely, and is largely due to genetics.

The genes rs10885406 and s7903146 can be used as markers for a person being a hapA haplotype (a set of DNA polymorphisms inherited together). HapA individuals vs those non-HapA were shown to have different weight gains in response to different diets over time. 

When protein intake from the 5th percentile (12.1% of total energy) to the 95th percentile (21.0% of total energy) was plotted against weight gain, individuals carrying HapA were less sensitive to protein intake with regard to weight gain.


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In homozygous HapA carriers, annual weight gain was 225–258 g/y, almost irrespective of protein intake. In contrast, in homozygous noncarriers of HapA, annual weight gain increased from 106 g/y at low protein intakes (12.1% of total energy) to 356 g/y at high protein intakes (21.0% of total energy).

In the same way, the rs12255372 variation is used to asses a persons reaction to low or high fat diets and offer advice on which diet is best to avoid obesity.

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