As an additional offering to our telomere length testing kit, we also give clients the option for longevity genotyping of the ACE, APOC3 and APOE genes. These genes are strongly correlated to longevity as well as other factors important to health and wellness. In this post, we will overview what information can be gleaned from our longevity genotyping platform.
Recent gerontology studies are clear about the factors influencing maximal lifespan. While positive lifestyle choices, exercise, and a stress-free life are all linked to improved health and increased longevity, the ability to reach the age of a centenarian (100+) seems to be largely (~70%) of genetic nature.
By applying known statistical correlations between different polymorphisms of APOE, ACE, and APOC3 – genes that have proven to be the top 3 longevity influencers –, we are calculating the relative odds of reaching 100 years in comparison to the general population, based on these three genes.
Also, through our client panel, we will soon provide interpretations on what these genes mean for nutrition and exercise. An overview of this information is below:
APOE Interpretations: Nutrition
First of all, it is one of the genes most strongly related to nutritional needs. Having its roots in Mediterranean diets and the separation between southern and northern European populations, this gene helps to predict the optimal Fat/Protein/Carbohydrate proportion that an individual is best adapted to.
ApoE genotyping provide access to diet recommendations for the so-called ApoE diet, which informs clients of the proportion of energy sources that are beneficial for his or her body.
ACE Interpretations: Athletics and Body Type
ACE is most strongly related to body type and athletic build. People with different polymorphisms of ACE may respond better to bodybuilding, while those with others are more suited for endurance exercise. The chart below gives an overview of how to interpret your data for your body type.
In short, the I/I allele is most suitable for endurance athletes, the I/D allele is most suitable for mixed training, and the D/D allele is most suited for body builders.
APOC3 is not significantly related to any type of superior lifestyle for health, however it has been found to be strongly correlated to longevity. Each C variant appears to add about 25% percent odds of becoming a centenarian.