U-698-MHomo sapiens (Human)Cancer cell line

Also known as: U698, U-698, U698M, U698-M, U-698M, U-698 M

🤖 AI SummaryBased on 10 publications

Quick Overview

Human B-cell lymphoma cell line with unique characteristics.

Detailed Summary

The U-698-M cell line is a human B-cell lymphoma cell line derived from a lymphoma case. It is notable for lacking the Epstein-Barr virus (EBV) genome, distinguishing it from many other lymphoid cell lines. This cell line has been used in studies examining the characteristics of B-cell lymphomas and their molecular profiles. Research has shown that U-698-M does not carry the EBV genome, which is a significant feature as most B-cell lymphoma lines are EBV-positive. The cell line has been utilized in investigations related to the expression of surface markers and the absence of EBV receptors, contributing to the understanding of B-cell malignancies. Additionally, it has been part of studies on the genetic and molecular characteristics of lymphoid malignancies, providing insights into the mechanisms of B-cell transformation and progression.

Research Applications

Study of B-cell lymphomasInvestigation of EBV-negative B-cell linesAnalysis of surface marker expressionMolecular profiling of lymphoid malignancies

Key Characteristics

Lacks EBV genomeB-cell originUsed in studies of lymphoid malignancies

Generated on 6/14/2025

Basic Information

Database ID	CVCL_0017
Species	Homo sapiens (Human)

Donor Information

Age	7
Age Category	Pediatric
Sex	Male

Disease Information

Disease	Non-Hodgkin lymphoma
Lineage	Lymphoid
Subtype	B-Lymphoblastic Leukemia/Lymphoma
OncoTree Code	BLL

DepMap Information

Source Type	DSMZ
Source ID	ACH-001680_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Tyr220Cys (c.659A>G)	Unspecified	-	PubMed=21173094
MutationSimple	ARID1A	p.Arg1446Ter (c.4336C>T)	Heterozygous	-	Unknown, Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

D13S317

11,13

D16S539

11,12

D18S51

15,18

D19S433

13,16

D21S11

29,30

D2S1338

16,20

D3S1358

14,15

D5S818

11,13

D7S820

8,10

D8S1179

11,13

FGA

22,24

Penta D

11,12

Penta E

11,12

TH01

6,10

TPOX

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Continuous lymphoid cell lines with characteristics of B cells (bone-marrow-derived), lacking the Epstein-Barr virus genome and derived from three human lymphomas.

Sundstrom C.

Proc. Natl. Acad. Sci. U.S.A. 71:3283-3286(1974).

DOI PubMed PMC

Establishment and characteristics of two unique cell lines from patients with lymphosarcoma.

Nilsson K., Sundstrom C.

Int. J. Cancer 13:808-823(1974).

DOI PubMed

Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid phosphatase.

Drexler H.G., Gaedicke G., Minowada J.

Leuk. Res. 9:537-548(1985).

DOI PubMed

Human tumor lines for cancer research.";

Fogh J.

Cancer Invest. 4:157-184(1986).

DOI PubMed

Isoenzyme studies in human leukemia-lymphoma cell lines -- III. Beta-hexosaminidase (E.C. 3.2.1.30).

Drexler H.G., Gaedicke G., Minowada J.

Leuk. Res. 9:549-559(1985).

DOI PubMed

Isoenzyme studies in human leukemia-lymphoma cell lines -- 1. carboxylic esterase.

Drexler H.G., Gaedicke G., Minowada J.

Leuk. Res. 9:209-229(1985).

DOI PubMed

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

DOI

Web Resources

proteinatlas.org tcpaportal.org