D341 MedHomo sapiens (Human)Cancer cell line

Also known as: H341, Med 341, D341, D-341, D341MD, D341MED, D341Med, D341_Med, D-341MED, D-341Med, D-341 Med-C, D-341 MED, D-341 Med

🤖 AI SummaryBased on 7 publications

Quick Overview

Human medulloblastoma cell line with known genetic alterations.

Detailed Summary

The D341 Med cell line is a human medulloblastoma cell line derived from a pediatric tumor. It is characterized by specific genetic alterations, including the PAX3-FKHR fusion gene, which is associated with alveolar rhabdomyosarcoma. This cell line has been used in studies investigating the molecular mechanisms of medulloblastoma and its response to various therapeutic agents. Research on D341 Med has contributed to understanding the role of fusion genes in cancer progression and the development of targeted therapies. The cell line is also part of the Cancer Cell Line Encyclopedia (CCLE) and has been utilized in drug sensitivity profiling studies.

Research Applications

Cancer researchDrug sensitivity profilingMolecular mechanisms of medulloblastomaTargeted therapy development

Key Characteristics

PAX3-FKHR fusion geneUsed in studies of alveolar rhabdomyosarcomaPart of the Cancer Cell Line Encyclopedia (CCLE)

Generated on 6/14/2025

Basic Information

Database ID	CVCL_0018
Species	Homo sapiens (Human)
Tissue Source	Brain, cerebellum[UBERON:UBERON_0002037]

Donor Information

Age	3
Age Category	Pediatric
Sex	Male
Subtype Features	MYC_Amplified

Disease Information

Disease	Medulloblastoma
Lineage	CNS/Brain
Subtype	Medulloblastoma
OncoTree Code	MBL

DepMap Information

Source Type	ATCC
Source ID	ACH-000095_source

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

10,11

D13S317

11,13

D16S539

12,14

D18S51

12,17

D19S433

D21S11

30,31

D2S1338

D3S1358

16,18

D5S818

11,12

D7S820

9,13

D8S1179

F13A01

6,7

F13B

8,10

FESFPS

10,13

FGA

19,23

LPL

Penta D

9,13

Penta E

8,15

TH01

6,9.3

TPOX

8,11

vWA

17,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Human medulloblastoma cell lines: investigating on cancer stem cell-like phenotype.

Pothier A., Merla C., Mancuso M.

Cancers (Basel) 12:226.1-226.14(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Data on the number and frequency of scientific literature citations for established medulloblastoma cell lines.

Ivanov D.P., Walker D.A., Coyle B., Grabowska A.M.

Data Brief 9:696-698(2016).

DOI PubMed PMC

In vitro models of medulloblastoma: choosing the right tool for the job.

Ivanov D.P., Coyle B., Walker D.A., Grabowska A.M.

J. Biotechnol. 236:10-25(2016).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Neuralized1 causes apoptosis and downregulates Notch target genes in medulloblastoma.

Marquez V.E., Cho Y.-J., Pomeroy S.L.

Neuro-oncol. 12:1244-1256(2010).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma.

Rauscher F.J. 3rd, Emanuel B.S., Rovera G., Barr F.G.

Nat. Genet. 5:230-235(1993).

DOI PubMed

Phenotypic and genotypic analysis of a human medulloblastoma cell line and transplantable xenograft (D341 Med) demonstrating amplification of c-myc.

Halperin E.C., Bigner D.D.

Am. J. Pathol. 130:472-484(1988).

PubMed PMC

Amplification of the c-myc gene in human medulloblastoma cell lines and xenografts.

Bigner S.H., Friedman H.S., Vogelstein B., Oakes W.J., Bigner D.D.

Cancer Res. 50:2347-2350(1990).

PubMed

Medulloblastoma cell-substrate interaction in vitro.";

Wikstrand C.J., Friedman H.S., Bigner D.D.

Invasion Metastasis 11:310-324(1991).

PubMed

Brain tumors.";

Ali-Osman F.

(In book chapter) Human cell culture. Vol. 2. Cancer cell lines part 2; Masters J.R.W., Palsson B.O. (eds.); pp.167-184; Kluwer Academic Publishers; New York; USA (1999).

DOI

Web Resources

genome.ucsc.edu web.archive.org