AN3-CAHomo sapiens (Human)Cancer cell line
Also known as: Acanthosis Nigricans 3rd attempt-CArcinoma, AN3, AN-3, AN3CA, AN3 Ca, AN3 CA, AN3_CA
Quick Overview
Human endometrial cancer cell line for research
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_0028 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Lymph node[UBERON:UBERON_0000029] |
Donor Information
| Age | 55 |
|---|---|
| Age Category | Adult |
| Sex | Female |
| Race | caucasian |
Disease Information
| Disease | Type I endometrial adenocarcinoma |
|---|---|
| Lineage | Uterus |
| Subtype | Endometrial Carcinoma |
| OncoTree Code | UCEC |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-000940_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Gly389Trp (c.1165G>T) | Heterozygous | - | Unknown |
| MutationSimple | PTEN | p.Arg130Glnfs*4 (c.389delG) | Homozygous | - | Wistar |
| MutationSimple | PIK3R1 | p.Arg557_Lys561delArgGluIleAspLysinsGln (c.1670_1681delGAGAAATTGACA) | Heterozygous | - | Unknown |
| MutationSimple | MAPK3 | p.Pro373Ser (c.1117C>T) | Heterozygous | - | Unknown |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Characterization of human cancer cell lines by reverse-phase protein arrays.
Liang H.
Cancer Cell 31:225-239(2017).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
A comprehensive transcriptional portrait of human cancer cell lines.
Settleman J., Seshagiri S., Zhang Z.-M.
Nat. Biotechnol. 33:306-312(2015).
DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.
Lessey B.A., Jordan V.C., Bradford A.P.
Gynecol. Oncol. 127:241-248(2012).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
PTEN deficiency in endometrioid endometrial adenocarcinomas predicts sensitivity to PARP inhibitors.
Lord C.J., Ashworth A., Reis-Filho J.S.
Sci. Transl. Med. 2:53ra75.1-53ra75.8(2010).
Genomic characterization of gene copy-number aberrations in endometrial carcinoma cell lines derived from endometrioid-type endometrial adenocarcinoma.
Zhang W.
Technol. Cancer Res. Treat. 9:179-189(2010).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
Growth in continuous culture, and in hamsters, of cells from a neoplasm associated with acanthosis nigricans.
Ollendorf-Curth H.
J. Natl. Cancer Inst. 33:441-456(1964).
Immunocytochemical analysis of cell lines derived from solid tumors.
Quentmeier H., Osborn M., Reinhardt J., Zaborski M., Drexler H.G.
J. Histochem. Cytochem. 49:1369-1378(2001).
Polymorphic enzyme analysis of cultured human tumor cell lines.";
Dracopoli N.C., Fogh J.
J. Natl. Cancer Inst. 70:469-476(1983).