SiHaHomo sapiens (Human)Cancer cell line
Also known as: SIHA, Siha
Quick Overview
Human cervical cancer cell line with HPV16 infection, used in cancer research.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_0032 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Uterus, cervix[UBERON:UBERON_0000002] |
Donor Information
| Age | 55 |
|---|---|
| Age Category | Adult |
| Sex | Female |
Disease Information
| Disease | Squamous cell carcinoma of the cervix uteri |
|---|---|
| Lineage | Cervix |
| Subtype | Cervical Squamous Cell Carcinoma |
| OncoTree Code | CESC |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-000556_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
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Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Establishment, authenticity, and characterization of cervical cancer cell lines.
Garcia-Carranca A.M., Cerbon-Cervantes M.A., Alcantara-Quintana L.E.
Mol. Cell. Oncol. 9:2078628.1-2078628.10(2022).
Role of APOA1 in the resistance to platinum-based chemotherapy in squamous cervical cancer.
He Y., Han S.-B., Liu Y., Zhang J.-J., Wu Y.-M.
BMC Cancer 22:411.1-411.12(2022).
Proteomic datasets of HeLa and SiHa cell lines acquired by DDA-PASEF and diaPASEF.
Du X.-X., Wong L.-S., Goh W.W.-B.
Data Brief 41:107919.1-107919.7(2022).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Establishment, molecular and biological characterization of HCB-514: a novel human cervical cancer cell line.
dos Reis R., Andrade C.E., de Padua Souza C., Reis R.M.
Sci. Rep. 9:1913-1913(2019).
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.
Oncotarget 8:86369-86383(2017).
Cervical cancer cell line secretome highlights the roles of transforming growth factor-beta-induced protein ig-h3, peroxiredoxin-2, and NRF2 on cervical carcinogenesis.
Loutradis D., Vlahou A., Anagnou N.P., Pappa K.I.
BioMed Res. Int. 2017:4180703.1-4180703.15(2017).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
A comprehensive transcriptional portrait of human cancer cell lines.
Settleman J., Seshagiri S., Zhang Z.-M.
Nat. Biotechnol. 33:306-312(2015).
Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability.
Symer D.E., Gillison M.L.
Genome Res. 24:185-199(2014).
Individual karyotypes at the origins of cervical carcinomas.";
Duesberg P.H.
Mol. Cytogenet. 6:44.1-44.23(2013).
Differences of SiHa (human cancer of cervix) and BMG-1 (brain glioma) cell lines as 2D and 3D cultures.
Ravi M., Sah S., Bhammar R.
J. Cell. Physiol. 229:127-131(2014).
Amplified genes may be overexpressed, unchanged, or downregulated in cervical cancer cell lines.
Rangel-Lopez A., Kofman S., Berumen J.
PLoS ONE 7:E32667-E32667(2012).
The HPV transcriptome in HPV16 positive cell lines.";
Schmitt M., Pawlita M.
Mol. Cell. Probes 25:108-113(2011).
Identifying pH independent hypoxia induced genes in human squamous cell carcinomas in vitro.
Sorensen B.S., Toustrup K., Horsman M.R., Overgaard J., Alsner J.
Acta Oncol. 49:895-905(2010).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
Combined array-comparative genomic hybridization and single-nucleotide polymorphism-loss of heterozygosity analysis reveals complex genetic alterations in cervical cancer.
Gorter A., Kenter G.G., Fleuren G.J., Jordanova E.S.
BMC Genomics 8:53.1-53.13(2007).
Smad4 deficiency in cervical carcinoma cells.";
Schwarte-Waldhoff I.
Oncogene 24:810-819(2005).
Nucleotide sequences and further characterization of human papillomavirus DNA present in the CaSki, SiHa and HeLa cervical carcinoma cell lines.
Meissner J.D.
J. Gen. Virol. 80:1725-1733(1999).
Studies on a new human cell line (SiHa) derived from carcinoma of uterus. I. Its establishment and morphology.
Friedl F., Kimura I., Osato T., Ito Y.
Proc. Soc. Exp. Biol. Med. 135:543-545(1970).
Papillomavirus sequences integrate near cellular oncogenes in some cervical carcinomas.
Durst M., Croce C.M., Gissmann L., Schwarz E., Huebner K.
Proc. Natl. Acad. Sci. U.S.A. 84:1070-1074(1987).
Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines.
Howley P.M.
J. Virol. 61:962-971(1987).
Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines.
Yee C., Krishnan-Hewlett I., Baker C.C., Schlegel R., Howley P.M.
Am. J. Pathol. 119:361-366(1985).
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
Fogh J., Wright W.C., Loveless J.D.
J. Natl. Cancer Inst. 58:209-214(1977).