A-431Homo sapiens (Human)Cancer cell line
Also known as: A431/P, A431
Quick Overview
Human epidermoid carcinoma cell line for cancer research.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_0037 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Skin, epidermis[UBERON:UBERON_0001003] |
Donor Information
| Age | 85 |
|---|---|
| Age Category | Adult |
| Sex | Female |
Disease Information
| Disease | Skin squamous cell carcinoma |
|---|---|
| Lineage | Skin |
| Subtype | Cutaneous Squamous Cell Carcinoma |
| OncoTree Code | CSCC |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-001328_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Arg273His (c.818G>A) | Homozygous | - | Unknown, PubMed=16264262 |
| Gene fusion | EGFR | EGFR-PPARGC1A | - | - | from parent cell line A-431 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Quantitative phosphoproteomic analysis reveals system-wide signaling pathways regulated by site-specific phosphorylation of keratin-8 in skin squamous cell carcinoma derived cell line.
Sinha S., Vadivel C.K., Dhaka B., Gowda H., Vaidya M.M.
Proteomics 17:1600254.1-1600254.17(2017).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
Integrin signalling regulates YAP and TAZ to control skin homeostasis.
Sansom O.J., Thompson B.J.
Development 143:1674-1687(2016).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
OncoImmunology 3:e954893.1-e954893.12(2014).
A mass spectrometric-derived cell surface protein atlas.";
Aebersold R., Boheler K.R., Zandstra P.W., Wollscheid B.
PLoS ONE 10:E0121314-E0121314(2015).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
A comprehensive transcriptional portrait of human cancer cell lines.
Settleman J., Seshagiri S., Zhang Z.-M.
Nat. Biotechnol. 33:306-312(2015).
Evaluating the promiscuous nature of tyrosine kinase inhibitors assessed in A431 epidermoid carcinoma cells by both chemical- and phosphoproteomics.
Superti-Furga G., Bennett K.L., Heck A.J.R.
ACS Chem. Biol. 9:1490-1498(2014).
Breakpoint analysis of transcriptional and genomic profiles uncovers novel gene fusions spanning multiple human cancer types.
West R.B., Pollack J.R.
PLoS Genet. 9:E1003464-E1003464(2013).
Human tumor cell strains defective in the repair of alkylation damage.
Mattern M.R.
Carcinogenesis 1:21-32(1980).
The quantitative proteomes of human-induced pluripotent stem cells and embryonic stem cells.
Choo A.B.-H., Heck A.J.R.
Mol. Syst. Biol. 7:550-550(2011).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins.
Rinehart C., Seidel B., Yee D., Arteaga C.L., Engelman J.A.
J. Clin. Invest. 118:2609-2619(2008).
Radiation-induced effects on telomerase in gynecological cancer cell lines with different radiosensitivity and repair capacity.
Kurvinen K., Rantanen V., Syrjanen S.M., Johansson B.
Int. J. Radiat. Biol. 82:859-867(2006).
Immunocytochemical analysis of cell lines derived from solid tumors.
Quentmeier H., Osborn M., Reinhardt J., Zaborski M., Drexler H.G.
J. Histochem. Cytochem. 49:1369-1378(2001).
Short tandem repeat profiling provides an international reference standard for human cell lines.
Harrison M., Virmani A.K., Ward T.H., Ayres K.L., Debenham P.G.
Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001).
p53 mutations and presence of HPV DNA do not correlate with radiosensitivity of gynecological cancer cell lines.
Syrjanen S.M.
Gynecol. Oncol. 71:352-358(1998).
Screening the p53 status of human cell lines using a yeast functional assay.
Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Mol. Carcinog. 19:243-253(1997).
Culture of A-431 human epidermoid carcinoma cells in serum-free medium: effect of culture conditions on the binding of [125I]-epidermal growth factor.
Barka T., van der Noen H.M.
Am. J. Anat. 165:187-198(1982).
Differential expression of the amv gene in human hematopoietic cells.
Aaronson S.A., Wong-Staal F.
Proc. Natl. Acad. Sci. U.S.A. 79:2194-2198(1982).
Relationship between karyotype of tissue culture lines and tumorigenicity in nude mice.
Gershwin M.E., Lentz D., Owens R.B.
Exp. Cell Biol. 52:361-370(1984).
Transforming growth factors produced by certain human tumor cells: polypeptides that interact with epidermal growth factor receptors.
Todaro G.J., Fryling C.M., De Larco J.E.
Proc. Natl. Acad. Sci. U.S.A. 77:5258-5262(1980).
Different responses to EGF in two human carcinoma cell lines, A431 and UCVA-1, possessing high numbers of EGF receptors.
Gamou S., Kim Y.S., Shimizu N.
Mol. Cell. Endocrinol. 37:205-213(1984).
In vitro cultivation of human tumors: establishment of cell lines derived from a series of solid tumors.
Dosik H., Parks W.P.
J. Natl. Cancer Inst. 51:1417-1423(1973).
Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines.
Yee C., Krishnan-Hewlett I., Baker C.C., Schlegel R., Howley P.M.
Am. J. Pathol. 119:361-366(1985).
Radiation response of vulvar squamous cell carcinoma (UM-SCV-1A, UM-SCV-1B, UM-SCV-2, and A-431) cells in vitro.
Pekkola-Heino K., Kulmala J., Grenman S.E., Carey T.E., Grenman R.
Cancer Res. 49:4876-4878(1989).
Growth of the malignant and nonmalignant human squamous cells in a protein-free defined medium.
Rikimaru K., Toda H., Tachikawa N., Kamata N., Enomoto S.
In Vitro Cell. Dev. Biol. 26:849-856(1990).
Growth factors produced by sarcoma virus-transformed cells.";
Todaro G.J., De Larco J.E.
Cancer Res. 38:4147-4154(1978).