MV4-11Homo sapiens (Human)Cancer cell line

Also known as: MV4II, MV(4;11), MV411, MV4;11, MV 4;11, MV4:11, MV-4:11, MV-4-11

🤖 AI SummaryBased on 14 publications

Quick Overview

MV4-11 is a human leukemia cell line derived from a patient with acute myeloid leukemia (AML). It is characterized by the prese...

Detailed Summary

MV4-11 is a human leukemia cell line established from a patient with acute myeloid leukemia (AML). It is known for harboring the t(4;11)(q21;q23) chromosomal translocation, which leads to the formation of the MLL-AF4 fusion gene. This genetic alteration is associated with a distinct clinical and biological phenotype in AML, characterized by a high white blood cell count, poor prognosis, and resistance to conventional therapies. MV4-11 cells are frequently used in research to investigate the molecular mechanisms underlying AML, particularly the role of MLL fusion proteins in leukemogenesis. The cell line is also utilized to study the effects of various therapeutic agents on AML cells, including the evaluation of targeted therapies and drug resistance mechanisms. Additionally, MV4-11 has been employed in studies examining the functional consequences of MLL-AF4 fusion proteins, such as their impact on gene expression, cell proliferation, and differentiation. The presence of the MLL-AF4 fusion gene makes MV4-11 a valuable model for understanding the pathogenesis of AML and for developing novel therapeutic strategies.

Research Applications

Study of MLL-AF4 fusion gene in AMLInvestigation of leukemogenesis mechanismsEvaluation of therapeutic agents and drug resistanceAnalysis of gene expression and molecular pathwaysDevelopment of targeted therapies for AML

Key Characteristics

Presence of t(4;11)(q21;q23) chromosomal translocationMLL-AF4 fusion geneHigh white blood cell countPoor prognosisResistance to conventional therapies

Generated on 6/14/2025

Basic Information

Database ID	CVCL_0064
Species	Homo sapiens (Human)
Tissue Source	Peripheral blood[UBERON:UBERON_0000178]

Donor Information

Age	10
Age Category	Pediatric
Sex	Male

Disease Information

Disease	Acute monoblastic/monocytic leukemia
Lineage	Myeloid
Subtype	Acute Myeloid Leukemia
OncoTree Code	AML

DepMap Information

Source Type	ATCC
Source ID	ACH-000045_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationUnexplicit	FLT3	Internal tandem duplication (FLT3-ITD)	Unspecified	-	PubMed=12529668
Gene fusion	AFF1	KMT2A-AFF1, MLL-AFF1, ALL-1/AF4	-	In frame	from parent cell line SEMK2

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

10,12

D13S317

D16S539

11,12

D18S51

11,17

D19S433

D21S11

D2S1338

24,25

D3S1358

16,17

D5S818

11,12

D7S820

8,9

D8S1179

FGA

19,21

Penta D

9,10

Penta E

7,18

TH01

8,9.3

TPOX

8,11

vWA

14,15

Gene Expression Profile

Gene expression levels and statistical distribution

Loading cohorts...

Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

DOI PubMed PMC

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Golub T.R., Root D.E., Hahn W.C.

Sci. Data 1:140035-140035(2014).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Survey of activated FLT3 signaling in leukemia.";

Druker B.J., Heinrich M.C., Rush J., Polakiewicz R.D.

PLoS ONE 6:E19169-E19169(2011).

DOI PubMed PMC

National Cancer Institute pediatric preclinical testing program: model description for in vitro cytotoxicity testing.

Reynolds C.P.

Pediatr. Blood Cancer 56:239-249(2011).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Lysine acetylation targets protein complexes and co-regulates major cellular functions.

Walther T.C., Olsen J.V., Mann M.

Science 325:834-840(2009).

DOI PubMed

JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.

Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.

Leukemia 20:471-476(2006).

DOI PubMed

Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.

Fioretos T.

Leukemia 19:1042-1050(2005).

DOI PubMed

Malignant hematopoietic cell lines: in vitro models for the study of MLL gene alterations.

Drexler H.G., Quentmeier H., MacLeod R.A.F.

Leukemia 18:227-232(2004).

DOI PubMed

FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy.

Tsuchida M., Sugita K., Ida K., Hayashi Y.

Blood 103:1085-1088(2004).

DOI PubMed

FLT3 mutations in acute myeloid leukemia cell lines.";

Quentmeier H., Reinhardt J., Zaborski M., Drexler H.G.

Leukemia 17:120-124(2003).

DOI PubMed

Human factor-dependent leukemia cell lines.";

Tohyama K.

Int. J. Hematol. 65:309-317(1997).

DOI PubMed

Heterogeneity in MLL/AF-4 fusion messenger RNA detected by the polymerase chain reaction in t(4;11) acute leukemia.

Hilden J.M., Chen C.-S., Moore R., Frestedt J., Kersey J.H.

Cancer Res. 53:3853-3856(1993).

PubMed

The chromosome 4q21 gene (AF-4/FEL) is widely expressed in normal tissues and shows breakpoint diversity in t(4;11)(q21;q23) acute leukemia.

Korsmeyer S.J., Kersey J.H.

Blood 82:1080-1085(1993).

DOI PubMed

Growth factor requirements of childhood acute leukemia: establishment of GM-CSF-dependent cell lines.

Rovera G.

Blood 70:192-199(1987).

DOI PubMed

Origins and properties of hematopoietic growth factor-dependent cell lines.

Ihle J.N., Askew D.

Int. J. Cell Cloning 7:68-91(1989).

DOI PubMed

The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene.

Croce C.M., Canaani E.

Cell 71:701-708(1992).

DOI PubMed

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

DOI

Web Resources

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