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JurkatHomo sapiens (Human)Cancer cell line

Also known as: JURKAT, JM, JM-Jurkat, Jurkat-FHCRC, Jurkat FHCRC, FHCRC-11, FHCRC subclone 11, FCCH1024, JURKET, Jurcat (Occasionally.)

🤖 AI SummaryBased on 8 publications

Quick Overview

Jurkat is a human T-cell leukemia cell line used in cancer research.

Detailed Summary

Jurkat is a human T-cell leukemia cell line derived from a patient with acute T-cell leukemia. It is widely used in research for studying T-cell biology, immunology, and cancer mechanisms. The cell line is known for its use in investigating signal transduction pathways, gene expression, and drug screening. Jurkat cells are also utilized in studies related to apoptosis, cell cycle regulation, and immune response. Due to its well-characterized properties, Jurkat is a valuable model for understanding T-cell malignancies and developing targeted therapies.

Research Applications

Cancer researchImmunologySignal transductionDrug screeningApoptosis studiesCell cycle regulation

Key Characteristics

Well-characterized T-cell lineUsed in leukemia researchExpresses T-cell receptorsCommonly used in immunological studies
Generated on 6/14/2025

Basic Information

Database IDCVCL_0065
SpeciesHomo sapiens (Human)
Tissue SourcePeripheral blood[UBERON:UBERON_0000178]

Donor Information

Age14
Age CategoryPediatric
SexMale
Subtype FeaturesTAL1

Disease Information

DiseaseChildhood T acute lymphoblastic leukemia
LineageLymphoid
SubtypeT-Lymphoblastic Leukemia/Lymphoma
OncoTree CodeTLL

DepMap Information

Source TypeDSMZ
Source IDACH-000995_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleBAXp.Glu41Argfs*19 (c.121delG)Heterozygous-from parent cell line Jurkat
MutationSimpleBAXp.Glu41Glyfs*33 (c.121dupG)Heterozygous-from parent cell line Jurkat
MutationSimpleFBXW7p.Arg505Cys (c.1513C>T)Heterozygous-from parent cell line Jurkat
MutationSimpleINPP5Dp.Gln345Ter (c.1033C>T)Heterozygous-from parent cell line Jurkat
MutationSimpleINPP5Dc.1097+1065_1097+1112del47Heterozygous-from parent cell line Jurkat
MutationSimpleMSH2p.Arg711Ter (c.2131C>T)Homozygous-from parent cell line Jurkat
MutationSimpleMSH6p.Phe1088Serfs*2 (c.3261delC)Homozygous-from parent cell line Jurkat
MutationSimpleNOTCH1p.Arg1627His (c.4880G>A)Heterozygous-PubMed=15472075
MutationSimpleTP53p.Arg196Ter (c.586C>T)Unspecified-PubMed=25275298

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X,Y
CSF1PO
9,10,11
D13S317
8,10,11
D16S539
10,11
D18S51
13,14,20,21
D19S433
13,15.2
D21S11
31.2,32.2
D2S1338
19,23
D3S1358
15
D5S818
9
D7S820
8,10
D8S1179
12,14,15
FGA
20,21
Penta D
11,13
Penta E
9,10,12
TH01
6,9.3
TPOX
8,9,10
vWA
16,17,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.

Sanchez-Irizarry C., Blacklow S.C., Look A.T., Aster J.C.

Science 306:269-271(2004).

DOIPubMed

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOIPubMedPMC

Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines.

Lehtio J., Vesterlund M., Jafari R.

Nat. Commun. 13:1691.1-1691.19(2022).

DOIPubMedPMC

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOIPubMedPMC

The LL-100 panel: 100 cell lines for blood cancer studies.";

MacLeod R.A.F., Nagel S., Steube K.G., Uphoff C.C., Drexler H.G.

Sci. Rep. 9:8218-8218(2019).

DOIPubMedPMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOIPubMedPMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOIPubMedPMC

Next-generation HLA typing of 382 International Histocompatibility Working Group reference B-lymphoblastoid cell lines: report from the 17th International HLA and Immunogenetics Workshop.

Fernandez-Vina M.A.

Hum. Immunol. 80:449-460(2019).

DOIPubMedPMC

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

DOIPubMedPMC

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

DOIPubMedPMC

UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites.

Olsen J.V., Blagoev B.

Nat. Struct. Mol. Biol. 25:631-640(2018).

DOIPubMed

STR profiling of HTLV-1-infected cell lines.";

Raimondi V., Minuzzo S.A., Ciminale V., D'Agostino D.M.

Methods Mol. Biol. 1582:143-154(2017).

DOIPubMed

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOIPubMedPMC

An augmented multiple-protease-based human phosphopeptide atlas.";

Heck A.J.R.

Cell Rep. 11:1834-1843(2015).

DOIPubMed

Detection of viral proteins in human cells lines by xeno-proteomics: elimination of the last valid excuse for not testing every cellular proteome dataset for viral proteins.

Chernobrovkin A.L., Zubarev R.A.

PLoS ONE 9:E91433-E91433(2014).

DOIPubMedPMC

Dynamic DNA methylation across diverse human cell lines and tissues.

Crawford G.E., Absher D.M., Wold B.J., Myers R.M.

Genome Res. 23:555-567(2013).

DOIPubMedPMC

The analysis of N-glycans of cell membrane proteins from human hematopoietic cell lines reveals distinctions in their pattern.

Reinke S.O., Bayer M., Berger M., Hinderlich S., Blanchard V.

Biol. Chem. 393:731-747(2012).

DOIPubMed

High accuracy mutation detection in leukemia on a selected panel of cancer genes.

Cools J., Aerts S.

PLoS ONE 7:E38463-E38463(2012).

DOIPubMedPMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOIPubMedPMC

Comparative proteomic analysis of eleven common cell lines reveals ubiquitous but varying expression of most proteins.

Geiger T., Wehner A., Schaab C., Cox J., Mann M.

Mol. Cell. Proteomics 11:M111.014050-M111.014050(2012).

DOIPubMedPMC

Lysine acetylation targets protein complexes and co-regulates major cellular functions.

Walther T.C., Olsen J.V., Mann M.

Science 325:834-840(2009).

DOIPubMed

Inactivation of SHIP1 in T-cell acute lymphoblastic leukemia due to mutation and extensive alternative splicing.

Diccianni M.B.

Leuk. Res. 33:1562-1566(2009).

DOIPubMedPMC

Aberrant p53 protein expression and function in a panel of hematopoietic cell lines with different p53 mutations.

Hasegawa H., Yamada Y.

Eur. J. Haematol. 82:301-307(2009).

DOIPubMed

Human T-cell lines with well-defined T-cell receptor gene rearrangements as controls for the BIOMED-2 multiplex polymerase chain reaction tubes.

Langerak A.W.

Leukemia 21:230-237(2007).

DOIPubMed

Authenticity and drug resistance in a panel of acute lymphoblastic leukaemia cell lines.

Freitas J.R., Firth M.J., Perera K.U., de Klerk N.H., Kees U.R.

Br. J. Cancer 95:1537-1544(2006).

DOIPubMedPMC

JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.

Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.

Leukemia 20:471-476(2006).

DOIPubMed

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

DOI

Characterization of EBV-genome negative 'null' and 'T' cell lines derived from children with acute lymphoblastic leukemia and leukemic transformed non-Hodgkin lymphoma.

Schneider U., Schwenk H.-U., Bornkamm G.-W.

Int. J. Cancer 19:621-626(1977).

DOIPubMed

Characterization of 'T' and 'non-T' cell lines established from children with acute lymphoblastic leukemia and non-Hodgkin lymphoma after leukemic transformation.

Schneider U., Schwenk H.-U.

Haematol. Blood Transfus. 20:265-269(1977).

DOIPubMed

Detection of T-cell lymphoma-associated antigens on cord blood lymphocytes and phytohemagglutinin-stimulated blasts.

Kaplan J., Peterson W.D. Jr.

Cancer Res. 36:3471-3475(1976).

PubMed

Cell cycle dependency of a T-cell marker on lymphoblasts.";

Schwenk H.-U., Schneider U.

Blut 31:299-306(1975).

DOIPubMed

Inhibition of phorbol ester-induced cell activation in microgravity.

Limouse M., Manie S., Konstantinova I., Ferrua B., Schaffar L.

Exp. Cell Res. 197:82-86(1991).

DOIPubMed

Frequent mutations in the p53 tumor suppressor gene in human leukemia T-cell lines.

Cheng J., Haas M.

Mol. Cell. Biol. 10:5502-5509(1990).

DOIPubMedPMC

Isoenzyme studies in human leukemia-lymphoma cell lines -- 1. carboxylic esterase.

Drexler H.G., Gaedicke G., Minowada J.

Leuk. Res. 9:209-229(1985).

DOIPubMed

Isoenzyme studies in human leukemia-lymphoma cell lines -- III. Beta-hexosaminidase (E.C. 3.2.1.30).

Drexler H.G., Gaedicke G., Minowada J.

Leuk. Res. 9:549-559(1985).

DOIPubMed

The human Jurkat (FHCRC-11) cell line is heterogeneous in ploidy and cell size and releases detergent-soluble DNA.

LaGree K.A., Lee A.T., Stetten G., Strauss P.R.

Exp. Hematol. 16:686-690(1988).

PubMed

Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid phosphatase.

Drexler H.G., Gaedicke G., Minowada J.

Leuk. Res. 9:537-548(1985).

DOIPubMed

Interferon system defects in malignant T-cells.";

Xu B., Einhorn S.

Leukemia 8:425-434(1994).

PubMed

Homozygous loss of the MTS1/p16 and MTS2/p15 genes in lymphoma and lymphoblastic leukaemia cell lines.

Uppenkamp M.J., Nowrousian M.R., Seeber S., Opalka B.

Br. J. Haematol. 91:350-354(1995).

DOIPubMed

Cell surface c-kit receptors in human leukemia cell lines and pediatric leukemia: selective preservation of c-kit expression on megakaryoblastic cell lines during adaptation to in vitro culture.

Imaizumi M., Endo M., Takano N., Konno T.

Leukemia 10:102-105(1996).

PubMed

p16INK4/p15INK4B gene inactivation is a frequent event in malignant T-cell lines.

Einhorn S.

Eur. J. Haematol. 56:313-318(1996).

DOIPubMed

Metastatic potential of lymphoma/leukemia cell lines in SCID mice is closely related to expression of CD44.

Liu C., Kondo E., Minowada J., Akagi T.

Jpn. J. Cancer Res. 87:1070-1077(1996).

DOIPubMedPMC

Frameshift mutations of the hMSH6 gene in human leukemia cell lines.

Hirai H.

Jpn. J. Cancer Res. 89:33-39(1998).

DOIPubMedPMC

BAX frameshift mutations in cell lines derived from human haemopoietic malignancies are associated with resistance to apoptosis and microsatellite instability.

Brimmell M., Mendiola R., Mangion J., Packham G.

Oncogene 16:1803-1812(1998).

DOIPubMed

Telomere analysis by fluorescence in situ hybridization and flow cytometry.

Roos G.

Nucleic Acids Res. 26:3651-3656(1998).

DOIPubMedPMC

Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia.

Aizawa Y., Ueda R., Seto M.

Jpn. J. Cancer Res. 89:712-718(1998).

DOIPubMedPMC

PTEN gene alterations in lymphoid neoplasms.";

Sakai A., Thieblemont C., Wellmann A., Jaffe E.S., Raffeld M.

Blood 92:3410-3415(1998).

DOIPubMed

Heterogeneity of T-acute lymphoblastic leukemia (T-ALL) cell lines: suggestion for classification by immunophenotype and T-cell receptor studies.

Burger R., Hansen-Hagge T.E., Drexler H.G., Gramatzki M.

Leuk. Res. 23:19-27(1999).

DOIPubMed

Alterations of the p53, p21, p16, p15 and RAS genes in childhood T-cell acute lymphoblastic leukemia.

Sekiya T., Hayashi Y.

Leuk. Res. 23:115-126(1999).

DOIPubMed

Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines.

Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.

Leuk. Res. 24:255-262(2000).

DOIPubMed

Biological significance of the expression of HIV-related chemokine coreceptors (CCR5 and CXCR4) and their ligands by human hematopoietic cell lines.

Gaulton G.N., Ratajczak M.Z.

Leukemia 14:1821-1832(2000).

DOIPubMed

Corrigendum to: Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines Leukemia Research 24 (2000), 255-262.

Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.

Leuk. Res. 25:275-278(2001).

DOIPubMed

Characterization of expression of protein kinase C isozymes in human B-cell lymphoma: relationship between its expression and prognosis.

Kamimura K., Hojo H., Abe M.

Pathol. Int. 54:224-230(2004).

DOIPubMed

Web Resources

en.wikipedia.orgcells-talk.com141.61.102.20genome.ucsc.eduthermofisher.com

Anecdotal Information

  • Have been flown in space on Cosmos-2044 to study the inhibition of phorbol ester-induced cell activation in microgravity (PubMed=1915666)