SNU-398Homo sapiens (Human)Cancer cell line

Also known as: NCI-SNU-398, SNU398

🤖 AI SummaryBased on 10 publications

Quick Overview

Human hepatocellular carcinoma cell line with TERT promoter mutations and genomic instability.

Detailed Summary

SNU-398 is a human hepatocellular carcinoma (HCC) cell line derived from a primary tumor. It exhibits high-frequency TERT promoter mutations, which are associated with increased telomerase activity and tumor progression. The cell line shows genomic instability, including aneuploidy and copy number variations. SNU-398 is used in research to study the molecular mechanisms of HCC, particularly focusing on the role of TERT mutations in carcinogenesis. It is also utilized for drug sensitivity testing and understanding the genetic diversity in HCC.

Research Applications

Molecular mechanisms of HCCTERT promoter mutations in carcinogenesisDrug sensitivity testingGenomic instability studies

Key Characteristics

High-frequency TERT promoter mutationsGenomic instabilityAneuploidyCopy number variations
Generated on 6/14/2025

Basic Information

Database IDCVCL_0077
SpeciesHomo sapiens (Human)
Tissue SourceLiver[UBERON:UBERON_0002107]

Donor Information

Age42
Age CategoryAdult
SexMale
Raceasian

Disease Information

DiseaseAdult hepatocellular carcinoma
LineageLiver
SubtypeHepatocellular Carcinoma
OncoTree CodeHCC

DepMap Information

Source TypeATCC
Source IDACH-000221_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleTP53p.Ser215Ile (c.644G>T)Heterozygous-from parent cell line SNU-398
MutationSimpleCTNNB1p.Ser37Cys (c.110C>G)Heterozygous-from parent cell line SNU-398

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X,Y
CSF1PO
13
D13S317
11
D16S539
10,14
D18S51
15
D19S433
14,14.1
D21S11
29
D2S1338
19
D3S1358
17
D5S818
12
D7S820
10,11
D8S1179
12
FGA
22,23
Penta D
14
Penta E
12
TH01
7,9
TPOX
11
vWA
17,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

A pharmacogenomic landscape in human liver cancers.";

Hui L.-J.

Cancer Cell 36:179-193.e11(2019).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

Analysis of liver cancer cell lines identifies agents with likely efficacy against hepatocellular carcinoma and markers of response.

Couchy G., Calderaro J., Nault J.-C., Zucman-Rossi J., Rebouissou S.

Gastroenterology 157:760-776(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

Common telomerase reverse transcriptase promoter mutations in hepatocellular carcinomas from different geographical locations.

Cevik D., Yildiz G., Ozturk M.

World J. Gastroenterol. 21:311-317(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions.

Laurent C., Laurent A., Cherqui D., Balabaud C., Zucman-Rossi J.

Nat. Commun. 4:2218.1-2218.7(2013).

Genomic landscape of copy number aberrations enables the identification of oncogenic drivers in hepatocellular carcinoma.

Xu J.-C.

Hepatology 58:706-717(2013).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

Biology of SNU cell lines.";

Ku J.-L., Park J.-G.

Cancer Res. Treat. 37:1-19(2005).

Mutation of p53 gene in hepatocellular carcinoma cell lines with HBX DNA.

Won Y.-J., Kim S.-T., Park J.-G.

Int. J. Cancer 67:898-902(1996).

Characterization of cell lines established from human hepatocellular carcinoma.

Song S.-Y., Kim W.-H., Ki C.-W., Kim Y.-I.

Int. J. Cancer 62:276-282(1995).