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SNU-5Homo sapiens (Human)Cancer cell line

Also known as: NCI-SNU-5, SNU5

🤖 AI SummaryBased on 13 publications

Quick Overview

Human gastric cancer cell line with ZAK isoform overexpression and potential for drug sensitivity studies.

Detailed Summary

SNU-5 is a human gastric cancer cell line derived from a primary tumor, characterized by the overexpression of the ZAK kinase isoform TV1. This cell line has been studied in the context of gastric cancer, where ZAK TV1 is preferentially upregulated compared to normal tissues. Research indicates that ZAK TV1 plays a role in cancer signaling pathways, and its depletion leads to reduced cell growth. SNU-5 is also part of a larger dataset of cancer cell lines used for genomic and transcriptomic analyses, contributing to the understanding of cancer biology and therapeutic strategies. The cell line's genetic and molecular profiles support its use in investigating the mechanisms of cancer progression and drug response.

Research Applications

Genomic and transcriptomic analysisZAK isoform expression studiesDrug sensitivity profilingCancer signaling pathway investigation

Key Characteristics

Overexpression of ZAK TV1 isoformPotential for studying cancer progression mechanismsUse in drug response and sensitivity studies

Generated on 6/14/2025

Basic Information

Database ID	CVCL_0078
Species	Homo sapiens (Human)
Tissue Source	Ascites[UBERON:UBERON_0007795]

Donor Information

Age	33
Age Category	Adult
Sex	Female
Race	asian

Disease Information

Disease	Gastric adenocarcinoma
Lineage	Esophagus/Stomach
Subtype	Stomach Adenocarcinoma
OncoTree Code	STAD

DepMap Information

Source Type	ATCC
Source ID	ACH-000303_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Gly262_Ser269delGlyAsnLeuLeuGlyArgAsnSer (c.784_807del24)	Unspecified	-	PubMed=1676761
MutationSimple	CDKN2A	p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T)	Homozygous	-	from parent cell line HL-60

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

12

D13S317

8

D16S539

13

D18S51

13

D19S433

13.2,15

D21S11

29

D2S1338

17

D3S1358

16

D5S818

10

D7S820

8,12

D8S1179

14,15

FGA

21

Penta D

9,13

Penta E

18,19

TH01

9

TPOX

11

vWA

15,16

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Forty-nine gastric cancer cell lines with integrative genomic profiling for development of c-MET inhibitor.

Kragh M., Horak I.D., Chung H.C., Rha S.Y.

Int. J. Cancer 143:151-159(2018).

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.

Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.

OncoImmunology 3:e954893.1-e954893.12(2014).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

Molecular integrative clustering of Asian gastric cell lines revealed two distinct chemosensitivity clusters.

Yang H.H., Lee M.A.

PLoS ONE 9:E111146-E111146(2014).

Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.

Firestein R., Zhang Z.-M.

Nat. Commun. 5:3830.1-3830.8(2014).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

Biology of SNU cell lines.";

Ku J.-L., Park J.-G.

Cancer Res. Treat. 37:1-19(2005).

Biology of colorectal and gastric cancer cell lines.";

Park J.-G., Gazdar A.F.

J. Cell. Biochem. Suppl. 24:131-141(1996).

NCI-Navy Medical Oncology Branch cell line data base.";

Carney D.N., Minna J.D., Mulshine J.L.

J. Cell. Biochem. Suppl. 24:32-91(1996).

Characteristics of cell lines established from human gastric carcinoma.

Bang Y.-J., Kim J.-P., Gazdar A.F.

Cancer Res. 50:2773-2780(1990).

Occurrence of p53 gene abnormalities in gastric carcinoma tumors and cell lines.

Lee H.-D., Kim J.-P., Minna J.D., Gazdar A.F.

J. Natl. Cancer Inst. 83:938-943(1991).

Gastric tumor cell lines.";

Sekiguchi M., Suzuki T.

(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.287-316; Academic Press; New York; USA (1994).

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