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697Homo sapiens (Human)Cancer cell line

Also known as: Emory University-3, EU-3, Line 697

🤖 AI SummaryBased on 10 publications

Quick Overview

Human B-cell precursor acute lymphoblastic leukemia cell line with t(1;19) translocation

Detailed Summary

The 697 cell line is a human B-cell precursor acute lymphoblastic leukemia cell line characterized by the t(1;19)(q23;p13) translocation, which results in the E2A-PBX1 fusion gene. This cell line is commonly used in research related to leukemia, particularly in studies involving the E2A-PBX1 fusion gene and its role in leukemogenesis. The 697 cell line has been utilized in various studies to investigate gene expression profiles, drug sensitivity, and molecular mechanisms associated with this specific genetic abnormality. It is also part of the Cancer Cell Line Encyclopedia (CCLE) and has been used in high-throughput screening for drug discovery and functional genomics studies.

Research Applications

Leukemia researchE2A-PBX1 fusion gene studiesDrug sensitivity screeningGene expression profilingMolecular mechanisms of leukemogenesis

Key Characteristics

t(1;19)(q23;p13) translocationE2A-PBX1 fusion geneB-cell precursor lineageUsed in high-throughput drug screening
Generated on 6/14/2025

Basic Information

Database IDCVCL_0079
SpeciesHomo sapiens (Human)
Tissue SourceBone marrow[UBERON:UBERON_0002371]

Donor Information

Age12
Age CategoryPediatric
SexMale
Subtype FeaturesTCF3-PBX1

Disease Information

DiseaseB-lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3)
LineageLymphoid
SubtypeB-Lymphoblastic Leukemia/Lymphoma with t(1;19)(q23;p13.3);TCF3-PBX1
OncoTree CodeBLLTCF3PBX1

DepMap Information

Source TypeDSMZ
Source IDACH-000070_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
Gene fusionPBX1TCF3-PBX1, E2A-PBX1--PubMed=29786757

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X,Y
CSF1PO
11,12
D13S317
11,12
D16S539
11,12
D18S51
16
D19S433
12,14
D21S11
28,32.2
D2S1338
20,21
D3S1358
16,18
D5S818
11,13
D7S820
10,11
D8S1179
13
FGA
20,23
Penta D
10,13
Penta E
7,10
TH01
8,9
TPOX
8,11
vWA
16,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOIPubMedPMC

Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines.

Lehtio J., Vesterlund M., Jafari R.

Nat. Commun. 13:1691.1-1691.19(2022).

DOIPubMedPMC

Glucocorticoid receptor gene mutations confer glucocorticoid resistance in B-cell precursor acute lymphoblastic leukemia.

Minegishi M., Iwamoto S., Sugita K., Inukai T.

J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022).

DOIPubMed

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOIPubMedPMC

The LL-100 panel: 100 cell lines for blood cancer studies.";

MacLeod R.A.F., Nagel S., Steube K.G., Uphoff C.C., Drexler H.G.

Sci. Rep. 9:8218-8218(2019).

DOIPubMedPMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOIPubMedPMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOIPubMedPMC

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

DOIPubMedPMC

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

DOIPubMedPMC

Copy number abnormality of acute lymphoblastic leukemia cell lines based on their genetic subtypes.

Sugita K., Hosoi H.

Int. J. Hematol. 108:312-318(2018).

DOIPubMed

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOIPubMedPMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOIPubMedPMC

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Golub T.R., Root D.E., Hahn W.C.

Sci. Data 1:140035-140035(2014).

DOIPubMedPMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOIPubMedPMC

Resistance to the translation initiation inhibitor silvestrol is mediated by ABCB1/P-glycoprotein overexpression in acute lymphoblastic leukemia cells.

Chan K.K., Kinghorn A.D., Phelps M.A., Grever M.R., Lucas D.M.

AAPS J. 13:357-364(2011).

DOIPubMedPMC

A specific linkage between the incidence of TP53 mutations and type of chromosomal translocations in B-precursor acute lymphoblastic leukemia cell lines.

Tada M., Moriuchi T., Sugita K.

Am. J. Hematol. 85:535-537(2010).

DOIPubMedPMC

Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19).

Kurosawa H., Look A.T., Matsui H., Inaba T., Sugita K.

Blood 116:962-970(2010).

DOIPubMed

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOIPubMedPMC

Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.

Fioretos T.

Leukemia 19:1042-1050(2005).

DOIPubMed

Real-time reverse transcription polymerase chain reaction detection and quantification of t(1;19) (E2A-PBX1) fusion genes associated with leukaemia.

Curry J.D., Glaser M.C., Smith M.T.

Br. J. Haematol. 115:826-830(2001).

DOIPubMed

Biological significance of the expression of HIV-related chemokine coreceptors (CCR5 and CXCR4) and their ligands by human hematopoietic cell lines.

Gaulton G.N., Ratajczak M.Z.

Leukemia 14:1821-1832(2000).

DOIPubMed

EB-1, a tyrosine kinase signal transduction gene, is transcriptionally activated in the t(1;19) subset of pre-B ALL, which express oncoprotein E2a-Pbx1.

Fu X.-Y., McGrath S., Pasillas M., Nakazawa S., Kamps M.P.

Oncogene 18:4920-4929(1999).

DOIPubMed

Sensitivity to Fas-mediated apoptosis in pediatric acute lymphoblastic leukemia is associated with a mutant p53 phenotype and absence of Bcl-2 expression.

Zhou M.-X., Gu L.-B., Yeager A.M., Findley H.W. Jr.

Leukemia 12:1756-1763(1998).

DOIPubMed

Expression and regulation of Bcl-2, Bcl-xl, and Bax correlate with p53 status and sensitivity to apoptosis in childhood acute lymphoblastic leukemia.

Findley H.W. Jr., Gu L.-B., Yeager A.M., Zhou M.-X.

Blood 89:2986-2993(1997).

DOIPubMed

Overexpression of the MDM2 gene by childhood acute lymphoblastic leukemia cells expressing the wild-type p53 gene.

Zhou M.-X., Yeager A.M., Smith S.D., Findley H.W. Jr.

Blood 85:1608-1614(1995).

DOIPubMed

Homozygous deletions of the CDKN2 (MTS1/p16ink4) gene in cell lines established from children with acute lymphoblastic leukemia.

Findley H.W. Jr.

Leukemia 9:1159-1161(1995).

PubMed

Two new acute lymphoblastic leukemia cell lines with early B-cell phenotypes.

Findley H.W. Jr., Cooper M.D., Kim T.H., Alvarado C., Ragab A.H.

Blood 60:1305-1309(1982).

DOIPubMed

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

DOI