A-673Homo sapiens (Human)Cancer cell line
Also known as: A673, RMS 1598, RMS1598
A673
Quick Overview
Human rhabdomyosarcoma cell line with specific genetic features.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_0080 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Muscle[UBERON:UBERON_0001630] |
Donor Information
| Age | 15 |
|---|---|
| Age Category | Pediatric |
| Sex | Female |
| Subtype Features | EWS-FLI |
Disease Information
| Disease | Ewing sarcoma |
|---|---|
| Lineage | Bone |
| Subtype | Ewing Sarcoma |
| OncoTree Code | ES |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-000052_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| Gene deletion | CDKN2A | - | Homozygous | Possible | PubMed=26870271 |
| Gene fusion | EWSR1 | EWSR1-FLI1, EWS-FLI1 | - | Type 1 fusion | PubMed=15150091 |
| MutationSimple | BRAF | p.Val600Glu (c.1799T>A) | Unspecified | - | PubMed=26214590 |
| MutationSimple | TP53 | p.Ala119Glnfs*5 (c.353_354dupCA) (c.354_355insCA) | Homozygous | - | from parent cell line A-673 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
SLFN11 is widely expressed in pediatric sarcoma and induces variable sensitization to replicative stress caused by DNA-damaging agents.
Neale G., Tinkle C.L., Federico S.M., Stewart E.A., Shelat A.A.
Mol. Cancer Ther. 20:2151-2165(2021).
Quantitative proteomics of the Cancer Cell Line Encyclopedia.";
Sellers W.R., Gygi S.P.
Cell 180:387-402.e16(2020).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
Systematic multi-omics profiling of Ewing sarcoma cell lines.";
Orth M.F.
Thesis PhD (2021); Ludwig Maximilians University of Munich; Munich; Germany.
Growth factors produced by sarcoma virus-transformed cells.";
Todaro G.J., De Larco J.E.
Cancer Res. 38:4147-4154(1978).
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
Fogh J., Fogh J.M., Orfeo T.
J. Natl. Cancer Inst. 59:221-226(1977).
Human melanoma cells have both nerve growth factor and nerve growth factor-specific receptors on their cell surfaces.
Sherwin S.A., Sliski A.H., Todaro G.J.
Proc. Natl. Acad. Sci. U.S.A. 76:1288-1292(1979).
Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.
Fine D.L., Abbott B.J., Mayo J.G., Shoemaker R.H., Boyd M.R.
Cancer Res. 48:589-601(1988).
In vitro cultivation of human tumors: establishment of cell lines derived from a series of solid tumors.
Dosik H., Parks W.P.
J. Natl. Cancer Inst. 51:1417-1423(1973).
Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains.
Lubiniecki A.S., Girardi A.J., Galloway S.M., Bynum G.D.
Nature 288:724-727(1980).
Repair of O6-methylguanine in DNA by demethylation is lacking in Mer- human tumor cell strains.
Yarosh D.B., Foote R.S., Mitra S., Day R.S. 3rd
Carcinogenesis 4:199-205(1983).
Differential expression of the amv gene in human hematopoietic cells.
Aaronson S.A., Wong-Staal F.
Proc. Natl. Acad. Sci. U.S.A. 79:2194-2198(1982).
Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma.
Rauscher F.J. 3rd, Emanuel B.S., Rovera G., Barr F.G.
Nat. Genet. 5:230-235(1993).
Narrow spectrum of infrequent p53 mutations and absence of MDM2 amplification in Ewing tumours.
Salzer-Kuntschik M., Gadner H.
Oncogene 8:2683-2690(1993).
Novel method for the production of multiple colour chromosome paints for use in karyotyping by fluorescence in situ hybridisation.
Roberts I., Wienberg J., Nacheva E., Grace C., Griffin D.K., Coleman N.
Genes Chromosomes Cancer 25:241-250(1999).
Analysis of the expression of cell cycle regulators in Ewing cell lines: EWS-FLI-1 modulates p57KIP2and c-Myc expression.
Weissman B.E., Delattre O.
Oncogene 20:3258-3265(2001).
Mutations of the BRAF gene in human cancer.";
Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.
Nature 417:949-954(2002).
Characterization of the A673 cell line (Ewing tumor) by molecular cytogenetic techniques.
Martinez-Delgado B., Urioste M., Cigudosa J.C., Benitez J.
Cancer Genet. Cytogenet. 141:138-142(2003).
Re: Characterization of the A673 cell line (Ewing tumor) by molecular cytogenetic techniques.
Coleman N., Roberts I.
Cancer Genet. Cytogenet. 148:86-86(2004).
Extreme sensitivity to Yondelis (Trabectedin, ET-743) in low passaged sarcoma cell lines correlates with mutated p53.
Tercero J.C., Piris M.A., Jimeno J.M., Carnero A.
J. Cell. Biochem. 100:339-348(2007).
Levels of p27(kip1) determine Aplidin sensitivity.";
Diaz-Uriarte R., Aracil M., Tercero J.C., Jimeno J.M., Carnero A.
Mol. Cancer Ther. 6:1310-1316(2007).
Molecular characterization of commonly used cell lines for bone tumor research: a trans-European EuroBoNet effort.
Buerger H., Aigner T., Gabbert H.E., Poremba C.
Genes Chromosomes Cancer 49:40-51(2010).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
1q gain and CDT2 overexpression underlie an aggressive and highly proliferative form of Ewing sarcoma.
Debiec-Rychter M., Schaefer K.-L., de Alava E.
Oncogene 31:1287-1298(2012).
Oncogene mutation profiling of pediatric solid tumors reveals significant subsets of embryonal rhabdomyosarcoma and neuroblastoma with mutated genes in growth signaling pathways.
Borsu L., Barr F.G., Ladanyi M.
Clin. Cancer Res. 18:748-757(2012).
Human tumor cell strains defective in the repair of alkylation damage.
Mattern M.R.
Carcinogenesis 1:21-32(1980).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
Human rhabdomyosarcoma cell lines for rhabdomyosarcoma research: utility and pitfalls.
Linardic C.M.
Front. Oncol. 3:183.1-183.12(2013).
Characterization and drug resistance patterns of Ewing's sarcoma family tumor cell lines.
Jenabi J., Ji L.-Y., Triche T.J., Lawlor E.R., Reynolds C.P.
PLoS ONE 8:E80060-E80060(2013).
Levels of active tyrosine kinase receptor determine the tumor response to Zalypsis.
Aviles P., Santamaria G., Tercero J.C., Cuevas C., Carnero A.
BMC Cancer 14:281.1-281.10(2014).
The genomic landscape of the Ewing sarcoma family of tumors reveals recurrent STAG2 mutation.
Catchpoole D., Llombart-Bosch A., Waldman T., Khan J.
PLoS Genet. 10:E1004475-E1004475(2014).
Genomic landscape of Ewing sarcoma defines an aggressive subtype with co-association of STAG2 and TP53 mutations.
Zhang J.-H., Delattre O.
Cancer Discov. 4:1342-1353(2014).
A comprehensive transcriptional portrait of human cancer cell lines.
Settleman J., Seshagiri S., Zhang Z.-M.
Nat. Biotechnol. 33:306-312(2015).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Golub T.R., Root D.E., Hahn W.C.
Sci. Data 1:140035-140035(2014).
Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.
Harris E., Monks A., Morris J.
Mol. Cancer Ther. 14:2452-2462(2015).
CXCL14, CXCR7 expression and CXCR4 splice variant ratio associate with survival and metastases in Ewing sarcoma patients.
Schmidt T., Szuhai K., Hogendoorn P.C.W.
Eur. J. Cancer 51:2624-2633(2015).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
Exploring the surfaceome of Ewing sarcoma identifies a new and unique therapeutic target.
Zhang J., Rabbitts T.H.
Proc. Natl. Acad. Sci. U.S.A. 113:3603-3608(2016).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
Characterization of human cancer cell lines by reverse-phase protein arrays.
Liang H.
Cancer Cell 31:225-239(2017).