MHH-CALL-3Homo sapiens (Human)Cancer cell line

Also known as: MHHCALL3, MHH-cALL3, MHH-CALL3, MHH cALL 3, Mhh-Call 3

🤖 AI SummaryBased on 5 publications

Quick Overview

Human B-lineage leukemia cell line with t(1;19) translocation

Detailed Summary

MHH-CALL-3 is a human B-lineage leukemia cell line characterized by the t(1;19)(q23;p13) translocation, which results in the TCF3/E2A-PBX1 fusion gene. This cell line is commonly used in research on B-cell precursor acute lymphoblastic leukemia (B-ALL) and has been extensively studied for its genetic and molecular characteristics. The cell line is derived from a patient with B-ALL and is known for its expression of the TCF3/E2A-PBX1 fusion transcript, which is a hallmark of this specific subtype of leukemia. MHH-CALL-3 is utilized in studies related to leukemia biology, drug development, and molecular diagnostics due to its well-defined genetic profile and consistent behavior in experimental settings.

Research Applications

Leukemia researchMolecular diagnosticsDrug development

Key Characteristics

TCF3/E2A-PBX1 fusion geneB-lineage phenotypet(1;19) translocation

Generated on 6/14/2025

Basic Information

Database ID	CVCL_0089
Species	Homo sapiens (Human)
Tissue Source	Bone marrow[UBERON:UBERON_0002371]

Donor Information

Age	11
Age Category	Pediatric
Sex	Female
Subtype Features	TCF3-PBX1

Disease Information

Disease	B-lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3)
Lineage	Lymphoid
Subtype	B-Lymphoblastic Leukemia/Lymphoma with t(1;19)(q23;p13.3);TCF3-PBX1
OncoTree Code	BLLTCF3PBX1

DepMap Information

Source Type	DSMZ
Source ID	ACH-000032_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
Gene fusion	PBX1	TCF3-PBX1, E2A-PBX1	-	-	PubMed=29786757

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

10,12

D13S317

12,13

D16S539

11,12

D18S51

17,18

D19S433

14,15

D21S11

D2S1338

9,12

D3S1358

D5S818

11,12

D7S820

10,12

D8S1179

11,13

FGA

19,22

Penta D

9,12

Penta E

TH01

6,8

TPOX

8,10

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines.

Lehtio J., Vesterlund M., Jafari R.

Nat. Commun. 13:1691.1-1691.19(2022).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

DOI PubMed PMC

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.

Fioretos T.

Leukemia 19:1042-1050(2005).

DOI PubMed

Occurrence of TEL-AML1 fusion resulting from (12;21) translocation in human early B-lineage leukemia cell lines.

Janssen J.W.G., Drexler H.G.

Leukemia 11:441-447(1997).

DOI PubMed

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

DOI