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RS4;11Homo sapiens (Human)Cancer cell line

Also known as: RS411, RS(4;11), RS 4;11, RS4:11, RS4-11, RS-E11

🤖 AI SummaryBased on 13 publications

Quick Overview

Human leukemia cell line with t(4;11) translocation, used in leukemia research.

Detailed Summary

The RS4;11 cell line is a human leukemia cell line derived from a patient with acute lymphoblastic leukemia (ALL). It is characterized by the presence of the t(4;11)(q21;q23) chromosomal translocation, which results in the formation of the MLL-AF4 fusion gene. This cell line is widely used in research to study the molecular mechanisms of leukemia, particularly in the context of MLL gene alterations. The RS4;11 cell line has been utilized in studies involving drug sensitivity, genetic profiling, and the investigation of oncogenic pathways. It is also part of the Cancer Cell Line Encyclopedia (CCLE) and has been used in various studies to understand the genetic and molecular basis of leukemia. The cell line is maintained in culture and is available for research purposes.

Research Applications

Leukemia researchMLL gene alterationsDrug sensitivity testingGenetic profiling

Key Characteristics

t(4;11)(q21;q23) translocationMLL-AF4 fusion geneUsed in drug screeningPart of CCLE
Generated on 6/14/2025

Basic Information

Database IDCVCL_0093
SpeciesHomo sapiens (Human)
Tissue SourceBone marrow[UBERON:UBERON_0002371]

Donor Information

Age32
Age CategoryAdult
SexFemale
Racecaucasian
Subtype FeaturesKMT2A

Disease Information

DiseaseB-lymphoblastic leukemia/lymphoma with t(v;11q23.3)
LineageLymphoid
SubtypeB-Lymphoblastic Leukemia/Lymphoma with t(v;11q23.3);KMT2A Rearranged
OncoTree CodeBLLKMT2A

DepMap Information

Source TypeATCC
Source IDACH-000874_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleNSD2p.Glu1099Lys (c.3295G>A)Heterozygous-PubMed=35124168
Gene fusionAFF1KMT2A-AFF1, MLL-AFF1, ALL-1/AF4-In framefrom parent cell line SEMK2

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X
CSF1PO
11,12
D13S317
11
D16S539
11,12
D18S51
12,16
D19S433
12,14
D21S11
28,30
D2S1338
20,25
D3S1358
15,17
D5S818
12
D7S820
8,12
D8S1179
13,14
FGA
23,24,25
Penta D
8.4,10
Penta E
5,7
TH01
6,9.3
TPOX
8
vWA
14,17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOIPubMedPMC

Glucocorticoid receptor gene mutations confer glucocorticoid resistance in B-cell precursor acute lymphoblastic leukemia.

Minegishi M., Iwamoto S., Sugita K., Inukai T.

J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022).

DOIPubMed

The RS4;11 cell line as a model for leukaemia with t(4;11)(q21;q23): revised characterisation of cytogenetic features.

Ragusa D., Makarov E.M., Britten O., Moralli D., Green C.M., Tosi S.

Cancer Rep. 2:e1207.1-e1207.11(2019).

DOIPubMedPMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOIPubMedPMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOIPubMedPMC

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

DOIPubMedPMC

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

DOIPubMedPMC

Copy number abnormality of acute lymphoblastic leukemia cell lines based on their genetic subtypes.

Sugita K., Hosoi H.

Int. J. Hematol. 108:312-318(2018).

DOIPubMed

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOIPubMedPMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOIPubMedPMC

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Golub T.R., Root D.E., Hahn W.C.

Sci. Data 1:140035-140035(2014).

DOIPubMedPMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOIPubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOIPubMedPMC

Survey of activated FLT3 signaling in leukemia.";

Druker B.J., Heinrich M.C., Rush J., Polakiewicz R.D.

PLoS ONE 6:E19169-E19169(2011).

DOIPubMedPMC

National Cancer Institute pediatric preclinical testing program: model description for in vitro cytotoxicity testing.

Reynolds C.P.

Pediatr. Blood Cancer 56:239-249(2011).

DOIPubMedPMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOIPubMedPMC

Array CGH of fusion gene-positive leukemia-derived cell lines reveals cryptic regions of genomic gain and loss.

Dexter T.J., Ashworth A., Kearney L.

Genes Chromosomes Cancer 45:554-564(2006).

DOIPubMed

JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.

Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.

Leukemia 20:471-476(2006).

DOIPubMed

Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.

Fioretos T.

Leukemia 19:1042-1050(2005).

DOIPubMed

Malignant hematopoietic cell lines: in vitro models for the study of MLL gene alterations.

Drexler H.G., Quentmeier H., MacLeod R.A.F.

Leukemia 18:227-232(2004).

DOIPubMed

Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia.

Aizawa Y., Ueda R., Seto M.

Jpn. J. Cancer Res. 89:712-718(1998).

DOIPubMedPMC

Occurrence of TEL-AML1 fusion resulting from (12;21) translocation in human early B-lineage leukemia cell lines.

Janssen J.W.G., Drexler H.G.

Leukemia 11:441-447(1997).

DOIPubMed

Heterogeneity in MLL/AF-4 fusion messenger RNA detected by the polymerase chain reaction in t(4;11) acute leukemia.

Hilden J.M., Chen C.-S., Moore R., Frestedt J., Kersey J.H.

Cancer Res. 53:3853-3856(1993).

PubMed

The chromosome 4q21 gene (AF-4/FEL) is widely expressed in normal tissues and shows breakpoint diversity in t(4;11)(q21;q23) acute leukemia.

Korsmeyer S.J., Kersey J.H.

Blood 82:1080-1085(1993).

DOIPubMed

A reverse transcriptase-polymerase chain reaction detects heterogeneous chimeric mRNAs in leukemias with 11q23 abnormalities.

Kodera Y., Nakazawa S., Saito H., Takahashi T., Ueda R.

Blood 83:2912-2921(1994).

DOIPubMed

Human acute leukemia cell line with the t(4;11) chromosomal rearrangement exhibits B lineage and monocytic characteristics.

Stong R.C., Korsmeyer S.J., Parkin J.L., Arthur D.C., Kersey J.H.

Blood 65:21-31(1985).

DOIPubMed

Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias.

Rowley J.D., Diaz M.O.

Proc. Natl. Acad. Sci. U.S.A. 88:10735-10739(1991).

DOIPubMedPMC

Phenotypic and genotypic characterization of 14 leukemia and lymphoma cell lines with 11q23 translocations.

Ueda R., Nakazawa S.

Leuk. Res. 16:1155-1163(1992).

DOIPubMed

The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene.

Croce C.M., Canaani E.

Cell 71:701-708(1992).

DOIPubMed

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

DOI

Web Resources

cccells.orgpptpinvitro.org