SNU-1Homo sapiens (Human)Cancer cell line

Also known as: NCI-SNU-1, SNU1

🤖 AI SummaryBased on 14 publications

Quick Overview

SNU-1 is a human gastric cancer cell line used in cancer research.

Detailed Summary

SNU-1 is a human gastric cancer cell line that has been utilized in various cancer research studies. It is part of a collection of cell lines used to study the molecular mechanisms of gastric cancer. The cell line is known for its use in investigating genetic and molecular alterations associated with cancer progression. Research on SNU-1 has contributed to understanding the role of specific genes and pathways in cancer development and treatment response.

Generated on 6/14/2025

Basic Information

Database ID	CVCL_0099
Species	Homo sapiens (Human)
Tissue Source	Stomach[UBERON:UBERON_0000945]

Donor Information

Age	44
Age Category	Adult
Sex	Male
Race	asian

Disease Information

Disease	Gastric adenocarcinoma
Lineage	Esophagus/Stomach
Subtype	Stomach Adenocarcinoma
OncoTree Code	STAD

DepMap Information

Source Type	ATCC
Source ID	ACH-000932_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationNone reported	TP53	-	-	-	PubMed=19787792
MutationSimple	KRAS	p.Gly12Asp (c.35G>A)	Unspecified	-	PubMed=29786757
MutationSimple	JAK1	p.Lys860Asnfs*16 (c.2580delA)	Heterozygous	-	from parent cell line SNU-1
MutationSimple	ATM	p.Leu1154fs*12 (c.3457_3458insT)	Heterozygous	-	from parent cell line SNU-1

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

12,13

D13S317

11,14

D16S539

9,12

D18S51

14,22

D19S433

13,14.2

D21S11

29,32.2

D2S1338

23,24

D3S1358

D5S818

12,13

D7S820

9,12

D8S1179

13,14

FGA

Penta D

10,11

Penta E

11,14

TH01

8,9.3

TPOX

8,10

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

DOI PubMed

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Forty-nine gastric cancer cell lines with integrative genomic profiling for development of c-MET inhibitor.

Kragh M., Horak I.D., Chung H.C., Rha S.Y.

Int. J. Cancer 143:151-159(2018).

DOI PubMed

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.

Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.

OncoImmunology 3:e954893.1-e954893.12(2014).

DOI PubMed PMC

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

Molecular integrative clustering of Asian gastric cell lines revealed two distinct chemosensitivity clusters.

Yang H.H., Lee M.A.

PLoS ONE 9:E111146-E111146(2014).

DOI PubMed PMC

Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.

Firestein R., Zhang Z.-M.

Nat. Commun. 5:3830.1-3830.8(2014).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Biology of SNU cell lines.";

Ku J.-L., Park J.-G.

Cancer Res. Treat. 37:1-19(2005).

DOI PubMed PMC

In vitro pharmacogenomic database and chemosensitivity predictive genes in gastric cancer.

Noh S.H., Rha S.Y.

Genomics 93:52-61(2009).

DOI PubMed

Mutations of the BRAF gene in human cancer.";

Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.

Nature 417:949-954(2002).

DOI PubMed

Mutations in hMSH6 alone are not sufficient to cause the microsatellite instability in colorectal cancer cell lines.

Ku J.-L., Yoon K.-A., Kim D.-Y., Park J.-G.

Eur. J. Cancer 35:1724-1729(1999).

DOI PubMed

Biology of colorectal and gastric cancer cell lines.";

Park J.-G., Gazdar A.F.

J. Cell. Biochem. Suppl. 24:131-141(1996).

DOI PubMed

NCI-Navy Medical Oncology Branch cell line data base.";

Carney D.N., Minna J.D., Mulshine J.L.

J. Cell. Biochem. Suppl. 24:32-91(1996).

DOI PubMed

Characteristics of cell lines established from human gastric carcinoma.

Bang Y.-J., Kim J.-P., Gazdar A.F.

Cancer Res. 50:2773-2780(1990).

PubMed

Occurrence of p53 gene abnormalities in gastric carcinoma tumors and cell lines.

Lee H.-D., Kim J.-P., Minna J.D., Gazdar A.F.

J. Natl. Cancer Inst. 83:938-943(1991).

DOI PubMed

Gastric tumor cell lines.";

Sekiguchi M., Suzuki T.

(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.287-316; Academic Press; New York; USA (1994).

DOI

Web Resources

tcpaportal.org