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SNU-601Homo sapiens (Human)Cancer cell line

Also known as: NCI-SNU-601, SNU601

🤖 AI SummaryBased on 10 publications

Quick Overview

Human gastric cancer cell line with known ZAK isoform expression and genetic alterations.

Detailed Summary

SNU-601 is a human gastric cancer cell line derived from ascitic fluid. It exhibits specific genetic alterations, including the preferential upregulation of the ZAK kinase isoform TV1, which has been implicated in cancer progression. This cell line is valuable for studying the role of ZAK isoforms in gastric cancer and their potential as therapeutic targets. Additionally, SNU-601 has been used in studies involving drug sensitivity and resistance, particularly in the context of targeted therapies and chemotherapy. The cell line's genetic profile, including copy number variations and mutations, provides insights into the molecular mechanisms underlying gastric cancer development and progression.

Research Applications

Analysis of ZAK isoform expression and functionDrug sensitivity and resistance studiesGenomic and transcriptomic profilingTargeted therapy development

Key Characteristics

Preferential upregulation of ZAK TV1 isoformGenetic alterations including copy number variationsUse in studying gastric cancer molecular mechanisms

Generated on 6/14/2025

Basic Information

Database ID	CVCL_0101
Species	Homo sapiens (Human)
Tissue Source	Ascites[UBERON:UBERON_0007795]

Donor Information

Age	34
Age Category	Adult
Sex	Male
Race	asian

Disease Information

Disease	Gastric signet ring cell adenocarcinoma
Lineage	Esophagus/Stomach
Subtype	Signet Ring Cell Carcinoma of the Stomach
OncoTree Code	SSRCC

DepMap Information

Source Type	KCLB
Source ID	ACH-000736_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg273His (c.818G>A)	Homozygous	-	Unknown, PubMed=16264262
MutationSimple	PIK3CA	p.Glu542Lys (c.1624G>A)	Unspecified	-	PubMed=31541927
MutationSimple	KRAS	p.Gly12Asp (c.35G>A)	Unspecified	-	PubMed=29786757

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

10,11

D13S317

9,12

D16S539

12

D18S51

14

D21S11

29,30

D3S1358

16

D5S818

10

D7S820

9,11

D8S1179

13,14

FGA

23

Penta D

8,15

Penta E

11,18

TH01

7,9

TPOX

8,11

vWA

16,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

TDP1 and TOP1 modulation in olaparib-resistant cancer determines the efficacy of subsequent chemotherapy.

Kim T.-Y., Lee K.W., Oh D.-Y., Kim J.-H., Bang Y.-J.

Cancers (Basel) 12:334.1-334.17(2020).

Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.

van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.

Nat. Commun. 10:3574.1-3574.11(2019).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Forty-nine gastric cancer cell lines with integrative genomic profiling for development of c-MET inhibitor.

Kragh M., Horak I.D., Chung H.C., Rha S.Y.

Int. J. Cancer 143:151-159(2018).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.

Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.

OncoImmunology 3:e954893.1-e954893.12(2014).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.

Firestein R., Zhang Z.-M.

Nat. Commun. 5:3830.1-3830.8(2014).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Biology of SNU cell lines.";

Ku J.-L., Park J.-G.

Cancer Res. Treat. 37:1-19(2005).

Screening of DNA copy-number aberrations in gastric cancer cell lines by array-based comparative genomic hybridization.

Okanoue T., Inazawa J.

Cancer Sci. 96:100-110(2005).

Characterization of chromosomal aberrations in human gastric carcinoma cell lines using chromosome painting.

Chun Y.-H., Kil J.-I., Suh Y.-S., Kim S.-H., Kim H., Park S.-H.

Cancer Genet. Cytogenet. 119:18-25(2000).

Establishment and characterization of human gastric carcinoma cell lines.

Bang Y.-J., Kim Y.I., Kim J.-P.

Int. J. Cancer 70:443-449(1997).