SNU-638Homo sapiens (Human)Cancer cell line

Also known as: SNU638

🤖 AI SummaryBased on 8 publications

Quick Overview

SNU-638 is a human gastric cancer cell line derived from ascites, used in cancer research.

Detailed Summary

SNU-638 is a human gastric cancer cell line established from ascites fluid, commonly used in cancer research to study gastric malignancies. It exhibits specific genetic and molecular characteristics that make it a valuable model for investigating cancer biology and therapeutic responses. Research on SNU-638 has focused on understanding genomic alterations, drug resistance mechanisms, and the role of specific genes like ZAK and MET in cancer progression. This cell line is utilized in studies related to chemotherapy resistance, targeted therapies, and molecular profiling to identify potential therapeutic targets and biomarkers.

Research Applications

Genomic and transcriptomic analysisDrug resistance mechanismsTargeted therapy developmentMolecular profilingCancer biology studies

Key Characteristics

Used in gastric cancer researchInvolved in studies of ZAK isoform usagePart of studies on MET and c-MET inhibitorsInvestigated for drug resistance mechanisms

Generated on 6/14/2025

Basic Information

Database ID	CVCL_0102
Species	Homo sapiens (Human)
Tissue Source	Ascites[UBERON:UBERON_0007795]

Donor Information

Age	48
Age Category	Adult
Sex	Male

Disease Information

Disease	Gastric adenocarcinoma
Lineage	Esophagus/Stomach
Subtype	Stomach Adenocarcinoma
OncoTree Code	STAD

DepMap Information

Source Type	KCLB
Source ID	ACH-001664_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg282Trp (c.844C>T)	Unspecified	-	PubMed=21173094, PubMed=1373872
MutationSimple	MET	p.Asn375Ser (c.1124A>G)	Heterozygous	-	PubMed=27822414

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

10,12

D13S317

D16S539

11,13

D18S51

14,16

D21S11

30.2,31

D3S1358

D5S818

10,13,14,15

D7S820

9,10

D8S1179

11,13

FGA

17,26,27

Penta D

Penta E

14,18

TH01

TPOX

8,11

vWA

14,19

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Forty-nine gastric cancer cell lines with integrative genomic profiling for development of c-MET inhibitor.

Kragh M., Horak I.D., Chung H.C., Rha S.Y.

Int. J. Cancer 143:151-159(2018).

DOI PubMed

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.

Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.

OncoImmunology 3:e954893.1-e954893.12(2014).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.

Firestein R., Zhang Z.-M.

Nat. Commun. 5:3830.1-3830.8(2014).

DOI PubMed PMC

Biology of SNU cell lines.";

Ku J.-L., Park J.-G.

Cancer Res. Treat. 37:1-19(2005).

DOI PubMed PMC

Screening of DNA copy-number aberrations in gastric cancer cell lines by array-based comparative genomic hybridization.

Okanoue T., Inazawa J.

Cancer Sci. 96:100-110(2005).

DOI PubMed PMC

Establishment and characterization of 5-fluorouracil-resistant gastric cancer cells.

Chung Y.M., Park S.-H., Park J.K., Kim Y.-T., Kang Y.-K., Yoo Y.D.

Cancer Lett. 159:95-101(2000).

DOI PubMed

Characterization of chromosomal aberrations in human gastric carcinoma cell lines using chromosome painting.

Chun Y.-H., Kil J.-I., Suh Y.-S., Kim S.-H., Kim H., Park S.-H.

Cancer Genet. Cytogenet. 119:18-25(2000).

DOI PubMed

Establishment and characterization of human gastric carcinoma cell lines.

Bang Y.-J., Kim Y.I., Kim J.-P.

Int. J. Cancer 70:443-449(1997).

DOI PubMed