UKE-1Homo sapiens (Human)Cancer cell line
Also known as: GM23245, UKE1
🤖 AI SummaryBased on 4 publications
Quick Overview
UKE-1 cell line with JAK2 V617F mutation for MPN research
Detailed Summary
UKE-1 is a human cell line derived from a patient with transformed myeloproliferative syndrome. It carries the JAK2 V617F mutation, which is commonly associated with myeloproliferative neoplasms (MPNs). This cell line is used in research to study the molecular mechanisms of MPNs and the role of JAK2 mutations in disease progression. UKE-1 has been utilized in studies examining the effects of JAK2 inhibition and the development of targeted therapies for MPN-related conditions. The cell line is also noted for its potential as a standard for quantifying JAK2 V617F allele burden in clinical settings.
Research Applications
JAK2 mutation analysisMPN researchDrug sensitivity testingQuantification of JAK2 V617F allele burden
Key Characteristics
JAK2 V617F mutationHomozygous mutationPotential standard for JAK2 V617F quantification
Generated on 6/14/2025
Basic Information
| Database ID | CVCL_0104 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Peripheral blood[UBERON:UBERON_0000178] |
Donor Information
| Additional Information |
|
|---|---|
| Age | 59 |
| Age Category | Adult |
| Sex | Female |
Disease Information
| Disease | Essential thrombocythemia |
|---|---|
| Lineage | Myeloid |
| Subtype | Acute Myeloid Leukemia |
| OncoTree Code | AML |
DepMap Information
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | JAK2 | p.Val617Phe (c.1849G>T) | Homozygous | - | from parent cell line UKE-1 |
Gene Expression Profile
Gene expression levels and statistical distribution
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Publications
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
A comprehensive transcriptional portrait of human cancer cell lines.
Settleman J., Seshagiri S., Zhang Z.-M.
Nat. Biotechnol. 33:306-312(2015).
Clonal evolution in UKE-1 cell line leading to an increase in JAK2 copy number.
Buors C., Douet-Guilbert N., Morel F., Lecucq L., Cassinat B., Ugo V.
Blood Cancer J. 2:e66.1-e66.3(2012).
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
Leukemia 20:471-476(2006).