BCP-1Homo sapiens (Human)Cancer cell line
Also known as: BCP1
Quick Overview
BCP-1 is a KSHV+ PEL cell line used in cancer research.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_0107 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Peripheral blood[UBERON:UBERON_0000178] |
Donor Information
| Age | 94 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Primary effusion lymphoma |
|---|---|
| Lineage | Lymphoid |
| Subtype | Primary Effusion Lymphoma |
| OncoTree Code | PEL |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-000923_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Asp259Asn (c.775G>A) | Heterozygous | - | Unknown, PubMed=19608668 |
| MutationSimple | TP53 | p.Met246Val (c.736A>G) | Unspecified | - | PubMed=27693639 |
| Gene deletion | PTEN | - | Hemizygous | - | Wistar |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
Yang H.H., Koeffler H.P.
BMC Cancer 18:940.1-940.13(2018).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
High-throughput RNA sequencing-based virome analysis of 50 lymphoma cell lines from the Cancer Cell Line Encyclopedia project.
O'Grady T., Baddoo M., Fewell C., Renne R., Flemington E.K.
J. Virol. 89:713-729(2015).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
Tumor suppressor genes FHIT and WWOX are deleted in primary effusion lymphoma (PEL) cell lines.
Roy D., Sin S.-H., Damania B., Dittmer D.P.
Blood 118:e32-e39(2011).
Mutational analysis of TP53, PTEN, PIK3CA and CTNNB1/beta-catenin genes in human herpesvirus 8-associated primary effusion lymphoma.
Boulanger E., Marchio A., Hong S.-S., Pineau P.
Haematologica 94:1170-1174(2009).
Functional p53 signaling in Kaposi's sarcoma-associated herpesvirus lymphomas: implications for therapy.
Burd C.E., Sin S.-H., Dittmer D.P.
J. Virol. 81:1912-1922(2007).
Distinct subsets of primary effusion lymphoma can be identified based on their cellular gene expression profile and viral association.
Knowles D.M.
J. Virol. 79:1244-1251(2005).
Lymphoma cell lines: in vitro models for the study of HHV-8+ primary effusion lymphomas (body cavity-based lymphomas).
Drexler H.G., Uphoff C.C., Gaidano G., Carbone A.
Leukemia 12:1507-1517(1998).
Establishing a KSHV+ cell line (BCP-1) from peripheral blood and characterizing its growth in Nod/SCID mice.
Moore P.S., Weiss R.A., Chang Y.
Blood 91:1671-1679(1998).
KSHV antibodies among Americans, Italians and Ugandans with and without Kaposi's sarcoma.
Moore P.S.
Nat. Med. 2:925-928(1996).
The leukemia-lymphoma cell line factsbook.";
Drexler H.G.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).