A-172Homo sapiens (Human)Cancer cell line
Also known as: A172, A 172, A-172 MG, A-172MG
A172
Quick Overview
Human glioblastoma cell line used in cancer research.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_0131 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Brain[UBERON:UBERON_0000955] |
Donor Information
| Age | 53 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Glioblastoma |
|---|---|
| Lineage | CNS/Brain |
| Subtype | Glioblastoma |
| OncoTree Code | GB |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-000558_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| Gene deletion | PTEN | - | Hemizygous | - | Wistar |
| Gene fusion | ABL1 | ABL1-CBFB | - | - | from parent cell line A-172 |
| MutationNone reported | IDH1 | - | - | - | PubMed=19435942 |
| MutationNone reported | TP53 | - | - | - | PubMed=19787792 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
DNA fingerprinting of glioma cell lines and considerations on similarity measurements.
Hamou M.-F., Delorenzi M., Hegi M.E.
Neuro-oncol. 14:701-711(2012).
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
lncRNA TUG1 inhibits the cancer stem cell-like properties of temozolomide-resistant glioma cells by interacting with EZH2.
Long J.
Mol. Med. Rep. 24:533.1-533.10(2021).
Quantitative proteomics of the Cancer Cell Line Encyclopedia.";
Sellers W.R., Gygi S.P.
Cell 180:387-402.e16(2020).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.
Nature 568:511-516(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Characteristics of A172 and T98G cell lines.";
Samoylovich M.P.
Tsitologiia 58:349-355(2016).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Golub T.R., Root D.E., Hahn W.C.
Sci. Data 1:140035-140035(2014).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
A comprehensive transcriptional portrait of human cancer cell lines.
Settleman J., Seshagiri S., Zhang Z.-M.
Nat. Biotechnol. 33:306-312(2015).
Breakpoint analysis of transcriptional and genomic profiles uncovers novel gene fusions spanning multiple human cancer types.
West R.B., Pollack J.R.
PLoS Genet. 9:E1003464-E1003464(2013).
Brain tumors.";
Ali-Osman F.
(In book chapter) Human cell culture. Vol. 2. Cancer cell lines part 2; Masters J.R.W., Palsson B.O. (eds.); pp.167-184; Kluwer Academic Publishers; New York; USA (1999).
Human glioma cell lines.";
Nister M., Westermark B.
(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.17-42; Academic Press; New York; USA (1994).
Tissue typing of cells in culture. III. HLA antigens of established human cell lines. Attempts at typing by the mixed hemadsorption technique.
Espmark J.A., Ahlqvist-Roth L., Sarne L., Persson A.
Tissue Antigens 11:279-286(1978).
Growth factors produced by sarcoma virus-transformed cells.";
Todaro G.J., De Larco J.E.
Cancer Res. 38:4147-4154(1978).
Human brain tumour cell strains with deficient host-cell reactivation of N-methyl-N'-nitro-N-nitrosoguanidine-damaged adenovirus 5.
Day R.S. 3rd, Ziolkowski C.H.J.
Nature 279:797-799(1979).
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
Fogh J., Wright W.C., Loveless J.D.
J. Natl. Cancer Inst. 58:209-214(1977).
Platelet-derived growth factor (PDGF) receptor activation in cell transformation and human malignancy.
Fleming T.P., Matsui T., Aaronson S.A.
Exp. Gerontol. 27:523-532(1992).
DNA content and chromosomes in permanent cultured cell lines derived from malignant human gliomas.
Bigner S.H., Bjerkvig R., Laerum O.D., Muhlbaier L.H., Bigner D.D.
Anal. Quant. Cytol. Histol. 9:435-444(1987).
Polysomy of chromosome 7 is correlated with overexpression of the erbB oncogene in human glioblastoma cell lines.
Henn W., Blin N., Zang K.-D.
Hum. Genet. 74:104-106(1986).
In vitro cultivation of human tumors: establishment of cell lines derived from a series of solid tumors.
Dosik H., Parks W.P.
J. Natl. Cancer Inst. 51:1417-1423(1973).
Polymorphic enzyme analysis of cultured human tumor cell lines.";
Dracopoli N.C., Fogh J.
J. Natl. Cancer Inst. 70:469-476(1983).
Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains.
Lubiniecki A.S., Girardi A.J., Galloway S.M., Bynum G.D.
Nature 288:724-727(1980).
Heterogeneity of genotypic and phenotypic characteristics of fifteen permanent cell lines derived from human gliomas.
Ruoslahti E., Herschman H.R., Eng L.F., Wikstrand C.J.
J. Neuropathol. Exp. Neurol. 40:201-229(1981).
Chromosomal composition of four permanent cultured cell lines derived from human gliomas.
Bigner S.H., Mark J., Bigner D.D.
Cancer Genet. Cytogenet. 10:335-349(1983).
Repair of O6-methylguanine in DNA by demethylation is lacking in Mer- human tumor cell strains.
Yarosh D.B., Foote R.S., Mitra S., Day R.S. 3rd
Carcinogenesis 4:199-205(1983).
Differential expression of the amv gene in human hematopoietic cells.
Aaronson S.A., Wong-Staal F.
Proc. Natl. Acad. Sci. U.S.A. 79:2194-2198(1982).
Breakpoint junctions of chromosome 9p deletions in two human glioma cell lines.
Pomykala H.M., Bohlander S.K., Broeker P.L., Olopade O.I., Diaz M.O.
Mol. Cell. Biol. 14:7604-7610(1994).
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers.
Frye C., Hu R., Swedlund B., Teng D.H.-F., Tavtigian S.V.
Nat. Genet. 15:356-362(1997).
Functional expression of bombesin receptor in most adult and pediatric human glioblastoma cell lines; role in mitogenesis and in stimulating the mitogen-activated protein kinase pathway.
Sharif T.R., Luo W., Sharif M.
Mol. Cell. Endocrinol. 130:119-130(1997).
Screening the p53 status of human cell lines using a yeast functional assay.
Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Mol. Carcinog. 19:243-253(1997).
Predicting chemoresistance in human malignant glioma cells: the role of molecular genetic analyses.
Krajewski S., Reed J.C., von Deimling A., Dichgans J.
Int. J. Cancer 79:640-644(1998).
Overexpression of protein kinase C epsilon in astroglial brain tumor derived cell lines and primary tumor samples.
Sharif T.R., Sharif M.
Int. J. Oncol. 15:237-243(1999).
Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines.
Van Meir E.G.
Brain Pathol. 9:469-479(1999).
Oncogenic epidermal growth factor receptor mutants with tandem duplication: gene structure and effects on receptor function.
Ciesielski M.J., Fenstermaker R.A.
Oncogene 19:810-820(2000).
Detection of multiple gene amplifications in glioblastoma multiforme using array-based comparative genomic hybridization.
Hui A.B.-Y., Lo K.-W., Yin X.-L., Poon W.-S., Ng H.-K.
Lab. Invest. 81:717-723(2001).
CP-31398, a novel p53-stabilizing agent, induces p53-dependent and p53-independent glioma cell death.
Wischhusen J., Naumann U., Ohgaki H., Rastinejad F., Weller M.
Oncogene 22:8233-8245(2003).
P-glycoprotein and multidrug resistance-associated protein mediate specific patterns of multidrug resistance in malignant glioma cell lines, but not in primary glioma cells.
Bahr O., Rieger J., Duffner F., Meyermann R., Weller M., Wick W.
Brain Pathol. 13:482-494(2003).
p53-defective tumors with a functional apoptosome-mediated pathway: a new therapeutic target.
Tomoda H., Yamori T., Tsuruo T.
J. Natl. Cancer Inst. 97:765-777(2005).
Overexpressed Skp2 within 5p amplification detected by array-based comparative genomic hybridization is associated with poor prognosis of glioblastomas.
Aoyagi M., Ohno K., Imoto I., Inazawa J.
Cancer Sci. 96:676-683(2005).
Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines.
Fine H.A.
Cancer Cell 9:391-403(2006).
Profiling and authentication of human cell lines using short tandem repeat (STR) loci: report from the National Cell Bank of Iran.
Azari S., Ahmadi N., Jeddi-Tehrani M., Shokri F.
Biologicals 35:195-202(2007).
Mechanisms of resistance of human glioma cells to Apo2 ligand/TNF-related apoptosis-inducing ligand.
Rieger J., Frank B., Weller M., Wick W.
Cell. Physiol. Biochem. 20:23-34(2007).
Molecular and phenotypic characterisation of paediatric glioma cell lines as models for preclinical drug development.
Jones C.
PLoS ONE 4:E5209-E5209(2009).
IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas.
Jones D.T.W., Collins V.P.
Neuro-oncol. 11:341-347(2009).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
MAP kinase-interacting kinase 1 regulates SMAD2-dependent TGF-beta signaling pathway in human glioblastoma.
Moncayo G., Hemmings B.A.
Cancer Res. 71:2392-2402(2011).