AGSHomo sapiens (Human)Cancer cell line
Quick Overview
AGS is a human gastric cancer cell line used in cancer research.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_0139 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Stomach[UBERON:UBERON_0000945] |
Donor Information
| Age | 54 |
|---|---|
| Age Category | Adult |
| Sex | Female |
| Race | caucasian |
Disease Information
| Disease | Gastric adenocarcinoma |
|---|---|
| Lineage | Esophagus/Stomach |
| Subtype | Stomach Adenocarcinoma |
| OncoTree Code | STAD |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-000880_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationNone reported | TP53 | - | - | - | PubMed=19787792 |
| MutationSimple | PIK3CA | p.Glu545Ala (c.1634A>C) | Heterozygous | - | from parent cell line AGS |
| MutationSimple | PIK3CA | p.Glu453Lys (c.1357G>A) | Heterozygous | - | from parent cell line AGS |
| MutationSimple | KRAS | p.Gly12Asp (c.35G>A) | Unspecified | - | PubMed=29786757 |
| MutationSimple | CTNNB1 | p.Gly34Glu (c.101G>A) | Heterozygous | - | from parent cell line AGS |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Acquisition of paclitaxel resistance modulates the biological traits of gastric cancer AGS cells and facilitates epithelial to mesenchymal transition and angiogenesis.
Niapour A., Seyedasli N.
Naunyn Schmiedebergs Arch. Pharmacol. 395:515-533(2022).
Quantitative proteomics of the Cancer Cell Line Encyclopedia.";
Sellers W.R., Gygi S.P.
Cell 180:387-402.e16(2020).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.
Nature 568:511-516(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Long non-coding RNA AK096174 promotes cell proliferation and invasion in gastric cancer by regulating WDR66 expression.
Zhang Y.-Q., Yu S.-T., Zhang Z.-Z., Zhao G., Xu J.
Biosci. Rep. 38:BSR20180277.1-BSR20180277.12(2018).
Forty-nine gastric cancer cell lines with integrative genomic profiling for development of c-MET inhibitor.
Kragh M., Horak I.D., Chung H.C., Rha S.Y.
Int. J. Cancer 143:151-159(2018).
Characterization of human cancer cell lines by reverse-phase protein arrays.
Liang H.
Cancer Cell 31:225-239(2017).
Genome sequence of the parainfluenza virus 5 strain that persistently infects AGS cells.
Randall R.E.
Genome Announc. 4:e00653.16.1-e00653.16.2(2016).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Golub T.R., Root D.E., Hahn W.C.
Sci. Data 1:140035-140035(2014).
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
OncoImmunology 3:e954893.1-e954893.12(2014).
A comprehensive transcriptional portrait of human cancer cell lines.
Settleman J., Seshagiri S., Zhang Z.-M.
Nat. Biotechnol. 33:306-312(2015).
Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.
Firestein R., Zhang Z.-M.
Nat. Commun. 5:3830.1-3830.8(2014).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
In vitro pharmacogenomic database and chemosensitivity predictive genes in gastric cancer.
Noh S.H., Rha S.Y.
Genomics 93:52-61(2009).
AGS and other tissue culture cells can unknowingly be persistently infected with PIV5; a virus that blocks interferon signalling by degrading STAT1.
Young D.F., Carlos T.S., Hagmaier K., Fan L., Randall R.E.
Virology 365:238-240(2007).
Chemosensitivity profile of cancer cell lines and identification of genes determining chemosensitivity by an integrated bioinformatical approach using cDNA arrays.
Yamori T.
Mol. Cancer Ther. 4:399-412(2005).
Modulation of biological phenotypes for tumor growth and metastasis by target-specific biological inhibitors in gastric cancer.
Kim B.-S., Kim M.Y., Chung H.C.
Int. J. Mol. Med. 4:203-212(1999).
Establishment and characterization of an in vitro model system for human adenocarcinoma of the stomach.
Burger N.L., Boerwinkle W.R., Gourley W.K.
Cancer Res. 43:1703-1709(1983).
Missense mutations and a deletion of the p53 gene in human gastric cancer.
Wada K., Uchida T., Nishisaki H., Nagao M., Kasuga M.
Biochem. Biophys. Res. Commun. 182:215-223(1992).
Establishment of a 5-fluorouracil-resistant human gastric cancer cell line and exploration of its biological characteristics.
Chang H.J., Cho M.-H., Choi M.Y., Lee K.E.
Res. Sq. 2022:1302156-1302156(2022).
Gastric tumor cell lines.";
Sekiguchi M., Suzuki T.
(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.287-316; Academic Press; New York; USA (1994).