BV-173Homo sapiens (Human)Cancer cell line

Also known as: BV173

🤖 AI SummaryBased on 15 publications

Quick Overview

BV-173 is a human chronic myeloid leukemia cell line derived from a patient in blast crisis.

Detailed Summary

BV-173 is a human chronic myeloid leukemia (CML) cell line established from a patient in blast crisis. It is characterized by the presence of the Philadelphia chromosome (Ph1) and the expression of the BCR-ABL fusion protein, which is a key driver in CML pathogenesis. The cell line is used in research to study the molecular mechanisms of CML, including the role of the BCR-ABL tyrosine kinase in leukemogenesis. BV-173 has been utilized in studies examining the genetic and molecular alterations associated with CML progression, including chromosomal abnormalities and gene expression profiles. It is also employed in drug development and testing for targeted therapies against CML.

Research Applications

Molecular studies of CMLAnalysis of BCR-ABL fusion proteinDrug development for CMLStudy of chromosomal abnormalities in CML

Key Characteristics

Presence of Philadelphia chromosome (Ph1)Expression of BCR-ABL fusion proteinUsed in studies of CML progression

Generated on 6/15/2025

Basic Information

Database ID	CVCL_0181
Species	Homo sapiens (Human)
Tissue Source	Peripheral blood[UBERON:UBERON_0000178]

Donor Information

Age	45
Age Category	Adult
Sex	Male
Subtype Features	BCR-ABL1

Disease Information

Disease	Chronic myeloid leukemia
Lineage	Myeloid
Subtype	Chronic Myeloid Leukemia, BCR-ABL1+
OncoTree Code	CMLBCRABL1

DepMap Information

Source Type	DSMZ
Source ID	ACH-000432_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	KMT2D	p.Gln4045Ter (c.12133C>T)	Heterozygous	-	from parent cell line BV-173
Gene fusion	ABL1	BCR-ABL1, BCR-ABL	-	BCR exon 1 fused to ABL1 exon 2	PubMed=10576511, PubMed=10071072, PubMed=8751477

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

11,12

D13S317

8,10

D16S539

11,13

D18S51

12,16

D19S433

D21S11

30,32

D2S1338

24,25

D3S1358

16,17

D5S818

10,12

D7S820

10,11

D8S1179

11,12,13

FGA

20,24

Penta D

Penta E

12,16

TH01

6,9.3

TPOX

8,10

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

The LL-100 panel: 100 cell lines for blood cancer studies.";

MacLeod R.A.F., Nagel S., Steube K.G., Uphoff C.C., Drexler H.G.

Sci. Rep. 9:8218-8218(2019).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

DOI PubMed PMC

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Genomic amplification of BCR/ABL1 and a region downstream of ABL1 in chronic myeloid leukaemia: a FISH mapping study of CML patients and cell lines.

Virgili A., Nacheva E.

Mol. Cytogenet. 3:15.1-15.12(2010).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Array CGH of fusion gene-positive leukemia-derived cell lines reveals cryptic regions of genomic gain and loss.

Dexter T.J., Ashworth A., Kearney L.

Genes Chromosomes Cancer 45:554-564(2006).

DOI PubMed

FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy.

Tsuchida M., Sugita K., Ida K., Hayashi Y.

Blood 103:1085-1088(2004).

DOI PubMed

ABL-BCR expression in BCR-ABL-positive human leukemia cell lines.";

Uphoff C.C., Habig S., Fombonne S., Matsuo Y., Drexler H.G.

Leuk. Res. 23:1055-1060(1999).

DOI PubMed

Leukemia cell lines: in vitro models for the study of Philadelphia chromosome-positive leukemia.

Drexler H.G., MacLeod R.A.F., Uphoff C.C.

Leuk. Res. 23:207-215(1999).

DOI PubMed

Establishment and characterization of human B cell precursor-leukemia cell lines.

Matsuo Y., Drexler H.G.

Leuk. Res. 22:567-579(1998).

DOI PubMed

Establishment of a Ph1-positive human cell line (BV173).";

Pegoraro L., Matera L., Ritz J., Levis A., Palumbo A., Biagini G.

J. Natl. Cancer Inst. 70:447-453(1983).

PubMed

Cell lines and clinical isolates derived from Ph1-positive chronic myelogenous leukemia patients express c-abl proteins with a common structural alteration.

Konopka J.B., Watanabe S.M., Singer J.W., Collins S.J., Witte O.N.

Proc. Natl. Acad. Sci. U.S.A. 82:1810-1814(1985).

DOI PubMed PMC

Ph positive CML cell lines.";

Keating A.

Baillieres Clin. Haematol. 1:1021-1029(1987).

DOI PubMed

Establishment and characterization of three new malignant lymphoid cell lines.

White H., Catovsky D., Foroni L., Luzzatto L., Goldman J.M.

Int. J. Cancer 39:89-93(1987).

DOI PubMed

Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias.

Rowley J.D., Diaz M.O.

Proc. Natl. Acad. Sci. U.S.A. 88:10735-10739(1991).

DOI PubMed PMC

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

DOI