CMKHomo sapiens (Human)Cancer cell line
Quick Overview
CMK is a human leukemia cell line derived from AML7, used in cancer research.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_0216 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Peripheral blood[UBERON:UBERON_0000178] |
Donor Information
| Age Category | Pediatric |
|---|---|
| Sex | Male |
Disease Information
| Disease | Acute megakaryoblastic leukemia in Down syndrome |
|---|---|
| Lineage | Myeloid |
| Subtype | Myeloid Leukemia Associated with Down Syndrome |
| OncoTree Code | MLADS |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-000641_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Asp49His (c.145G>C) | Heterozygous | - | from parent cell line Ishikawa |
| Gene fusion | FXR2 | TP53-FXR2 | - | - | PubMed=16778363 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Quantitative proteomics of the Cancer Cell Line Encyclopedia.";
Sellers W.R., Gygi S.P.
Cell 180:387-402.e16(2020).
The LL-100 panel: 100 cell lines for blood cancer studies.";
MacLeod R.A.F., Nagel S., Steube K.G., Uphoff C.C., Drexler H.G.
Sci. Rep. 9:8218-8218(2019).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Screening human cell lines for viral infections applying RNA-Seq data analysis.
Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.
PLoS ONE 14:E0210404-E0210404(2019).
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
Yang H.H., Koeffler H.P.
BMC Cancer 18:940.1-940.13(2018).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms.
Haferlach T., Shirahige K., Miyano S., Ogawa S.
Nat. Genet. 45:1232-1237(2013).
Dynamic DNA methylation across diverse human cell lines and tissues.
Crawford G.E., Absher D.M., Wold B.J., Myers R.M.
Genome Res. 23:555-567(2013).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
Leukemia 20:471-476(2006).
Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.
Fioretos T.
Leukemia 19:1042-1050(2005).
Corrigendum to: Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines Leukemia Research 24 (2000), 255-262.
Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.
Leuk. Res. 25:275-278(2001).
Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines.
Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.
Leuk. Res. 24:255-262(2000).
HIV infection of megakaryocytic cell lines.";
Sato T., Sekine H., Kakuda H., Miura N., Sunohara M., Fuse A.
Leuk. Lymphoma 36:397-404(2000).
Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia.
Aizawa Y., Ueda R., Seto M.
Jpn. J. Cancer Res. 89:712-718(1998).
Frameshift mutations of the hMSH6 gene in human leukemia cell lines.
Hirai H.
Jpn. J. Cancer Res. 89:33-39(1998).
Lack of c-mpl proto-oncogene transcripts and growth-stimulatory effects of thrombopoietin on human small cell lung cancer cell lines.
Shinohara A., Shimizu E., Takada M., Sone S.
Oncology 53:426-434(1996).
Growth and differentiation of a human megakaryoblastic cell line, CMK.
Nishida T., Hirai Y., Sato T., Fuse A., Miura Y.
Blood 74:42-48(1989).
Establishment of a human leukaemic cell line (CMK) with megakaryocytic characteristics from a Down's syndrome patient with acute megakaryoblastic leukaemia.
Sunami S., Okimoto Y., Nakajima H.
Br. J. Haematol. 72:184-190(1989).
Growth and differentiation of two human megakaryoblastic cell lines; CMK and UT-7.
Miura Y., Komatsu N., Suda T.
Prog. Clin. Biol. Res. 356:259-270(1990).
Human immunodeficiency virus infection of megakaryocytic cells.";
Sakaguchi M., Sato T., Groopman J.E.
Blood 77:481-485(1991).
Frequent mutations in the p53 gene in human myeloid leukemia cell lines.
Ishikawa F., Takaku F., Yazaki Y., Hirai H.
Blood 79:2378-2383(1992).
The leukemia-lymphoma cell line factsbook.";
Drexler H.G.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).