G-401Homo sapiens (Human)Cancer cell line
Also known as: G 401, G401
Quick Overview
Human kidney tumor cell line with rhabdoid features, used in cancer research.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_0270 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Kidney[UBERON:UBERON_0002113] |
Donor Information
| Age Category | Pediatric |
|---|---|
| Sex | Male |
| Race | caucasian |
Disease Information
| Disease | Rhabdoid tumor |
|---|---|
| Lineage | Kidney |
| Subtype | Rhabdoid Cancer |
| OncoTree Code | MRT |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-000096_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| Gene deletion | SMARCB1 | - | Homozygous | - | PubMed=11921280 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Quantitative proteomics of the Cancer Cell Line Encyclopedia.";
Sellers W.R., Gygi S.P.
Cell 180:387-402.e16(2020).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
WARNING: G-401 and SK-NEP-1 cell lines are not Wilms tumor cell lines.
Pritchard-Jones K., Perotti D.
Pediatr. Blood Cancer 66:e27741.1-e27741.2(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
SMARCB1 is required for widespread BAF complex-mediated activation of enhancers and bivalent promoters.
Irizarry R.A., Zhao K.-J., Ranish J.A., Kadoch C.
Nat. Genet. 49:1613-1623(2017).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.
Harris E., Monks A., Morris J.
Mol. Cancer Ther. 14:2452-2462(2015).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
Alteration of hSNF5/INI1/BAF47 detected in rhabdoid cell lines and primary rhabdomyosarcomas but not Wilms' tumors.
DeCristofaro M.F., Betz B.L., Wang W.-D., Weissman B.E.
Oncogene 18:7559-7565(1999).
hSNF5/INI1 inactivation is mainly associated with homozygous deletions and mitotic recombinations in rhabdoid tumors.
Mairal A., Delattre O., Aurias A.
Cancer Res. 59:3152-3156(1999).
Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer.";
Handgretinger R., Aurias A., Delattre O.
Nature 394:203-206(1998).