HEC-1-AHomo sapiens (Human)Cancer cell line
Also known as: Hec1A, HEC1A, HEC1-A, HEC-1A, Hec-1-A
Quick Overview
Human endometrial adenocarcinoma cell line for cancer research.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_0293 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Endometrium[UBERON:UBERON_0001295] |
Donor Information
| Age | 71 |
|---|---|
| Age Category | Adult |
| Sex | Female |
Disease Information
| Disease | Type II endometrial adenocarcinoma |
|---|---|
| Lineage | Uterus |
| Subtype | Endometrial Carcinoma |
| OncoTree Code | UCEC |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-000954_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Arg248Gln (c.743G>A) | Unspecified | Somatic mutation acquired during proliferation | PubMed=20575032 |
| MutationSimple | PMS2 | p.Arg802Ter (c.2404C>T) | Heterozygous | - | from parent cell line HEC-1 |
| MutationSimple | MSH6 | c.4001+1G>T | Heterozygous | Splice donor mutation | from parent cell line HEC-1 |
| MutationSimple | MSH6 | p.Phe1088Serfs*2 (c.3261delC) | Homozygous | - | from parent cell line Jurkat |
| MutationSimple | KRAS | p.Gly12Asp (c.35G>A) | Unspecified | - | PubMed=29786757 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
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Publications
Quantitative proteomics of the Cancer Cell Line Encyclopedia.";
Sellers W.R., Gygi S.P.
Cell 180:387-402.e16(2020).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Characterization of human cancer cell lines by reverse-phase protein arrays.
Liang H.
Cancer Cell 31:225-239(2017).
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Golub T.R., Root D.E., Hahn W.C.
Sci. Data 1:140035-140035(2014).
A comprehensive transcriptional portrait of human cancer cell lines.
Settleman J., Seshagiri S., Zhang Z.-M.
Nat. Biotechnol. 33:306-312(2015).
DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.
Lessey B.A., Jordan V.C., Bradford A.P.
Gynecol. Oncol. 127:241-248(2012).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
Genomic characterization of gene copy-number aberrations in endometrial carcinoma cell lines derived from endometrioid-type endometrial adenocarcinoma.
Zhang W.
Technol. Cancer Res. Treat. 9:179-189(2010).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Correlation between DNA alterations and p53 and p16 protein expression in cancer cell lines.
Murai Y., Hayashi S., Takahashi H., Tsuneyama K., Takano Y.
Pathol. Res. Pract. 201:109-115(2005).
Quantitative study on the correlation between p53 gene mutation and its expression in endometrial carcinoma cell lines.
Kamata Y., Watanabe J., Hata H., Hamano M., Kuramoto H.
Eur. J. Gynaecol. Oncol. 25:55-60(2004).
Three-dimensional coculture of endometrial cancer cells and fibroblasts in human placenta derived collagen sponges and expression matrix metalloproteinases in these cells.
Tanaka R., Saito T., Ashihara K., Nishimura M., Mizumoto H., Kudo R.
Gynecol. Oncol. 90:297-304(2003).
Variation in the extent of microsatellite instability in human cell lines with defects in different mismatch repair genes.
Yamada N.A., Castro A., Farber R.A.
Mutagenesis 18:277-282(2003).
Mutations of the BRAF gene in human cancer.";
Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.
Nature 417:949-954(2002).
In vitro effects of gonadotropin-releasing hormone (GnRH) analogue on cancer cell sensitivity to cis-platinum.
Ohta H., Sakamoto H., Satoh K.
Cancer Lett. 134:111-118(1998).
Presence of glycogen and growth-related variations in 58 cultured human tumor cell lines of various tissue origins.
Rousset M., Zweibaum A., Fogh J.
Cancer Res. 41:1165-1170(1981).
Studies of the growth and cytogenetic properties of human endometrial adenocarcinoma in culture and its development into an established line.
Kuramoto H.
Acta Obstet. Gynaecol. Jpn. 19:47-58(1972).
Cytogenetics of an endometrial adenocarcinoma cell line and its implications.
Pritchard M.L.
Gynecol. Oncol. 31:217-222(1988).
Characteristics of cell lines derived from normal and malignant endometrial tissue.
Noumoff J.S., Haydock S.W., Sachdeva R., Heyner S., Pritchard M.L.
Gynecol. Oncol. 27:141-149(1987).
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
Fogh J., Wright W.C., Loveless J.D.
J. Natl. Cancer Inst. 58:209-214(1977).
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
Fogh J., Fogh J.M., Orfeo T.
J. Natl. Cancer Inst. 59:221-226(1977).
HEC-1 cells: establishment of an in vitro experimental system in endometrial carcinoma.
Kawaguchi M.
(In book chapter) Cell and molecular biology of endometrial carcinoma; Kuramoto H., Nishida M. (eds.); pp.3-34; Springer; Tokyo; Japan (2003).