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HEC-1-BHomo sapiens (Human)Cancer cell line

Also known as: Hec1B, HEC1B, HEC1-B, Hec-1b, HEC-1B, Hec-1-B

🤖 AI SummaryBased on 10 publications

Quick Overview

Human endometrial carcinoma cell line for cancer research.

Detailed Summary

HEC-1-B is a human endometrial carcinoma cell line established from a 71-year-old female patient with endometrial carcinoma. It is widely used in research for studying endometrial cancer biology, hormone responses, and drug sensitivity. The cell line exhibits characteristics of epithelial cells, including specific hormone receptor expressions and growth patterns. HEC-1-B has been utilized in studies related to estrogen and progesterone signaling, as well as in investigations of genetic and molecular alterations associated with endometrial cancer. It is also part of various cell line panels for cancer research, such as the Cancer Cell Line Encyclopedia (CCLE) and other genomic studies.

Research Applications

Cancer biology researchHormone response studiesDrug sensitivity screeningGenomic and molecular profiling

Key Characteristics

Epithelial cell originEstrogen and progesterone receptor expressionUsed in drug response and resistance studiesPart of large cancer cell line panels

Generated on 6/15/2025

Basic Information

Database ID	CVCL_0294
Species	Homo sapiens (Human)
Tissue Source	Endometrium[UBERON:UBERON_0001295]

Donor Information

Age	71
Age Category	Adult
Sex	Female

Disease Information

Disease	Type II endometrial adenocarcinoma
Lineage	Uterus
Subtype	Endometrial Carcinoma
OncoTree Code	UCEC

DepMap Information

Source Type	ATCC
Source ID	ACH-000941_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg248Gln (c.743G>A)	Unspecified	Somatic mutation acquired during proliferation	PubMed=20575032
MutationNone reported	PTEN	-	-	-	PubMed=20944090
MutationSimple	PMS2	p.Arg802Ter (c.2404C>T)	Heterozygous	-	from parent cell line HEC-1
MutationSimple	MSH6	c.4001+1G>T	Heterozygous	Splice donor mutation	from parent cell line HEC-1
MutationSimple	MSH6	p.Phe1088Serfs*2 (c.3261delC)	Homozygous	-	from parent cell line Jurkat
MutationSimple	KRAS	p.Gly12Asp (c.35G>A)	Unspecified	-	PubMed=29786757

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

10,12

D13S317

11

D16S539

11,12

D18S51

16,20

D19S433

13

D21S11

30,31

D2S1338

18,19

D3S1358

15

D5S818

11,13

D7S820

9,11

D8S1179

13,14

FGA

21

Penta D

9,13

Penta E

11

TH01

6

TPOX

8,11

vWA

18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.

Lessey B.A., Jordan V.C., Bradford A.P.

Gynecol. Oncol. 127:241-248(2012).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

PTEN deficiency in endometrioid endometrial adenocarcinomas predicts sensitivity to PARP inhibitors.

Lord C.J., Ashworth A., Reis-Filho J.S.

Sci. Transl. Med. 2:53ra75.1-53ra75.8(2010).

Genomic characterization of gene copy-number aberrations in endometrial carcinoma cell lines derived from endometrioid-type endometrial adenocarcinoma.

Zhang W.

Technol. Cancer Res. Treat. 9:179-189(2010).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

HEC-1 cells.";

Kuramoto H., Hamano M., Imai M.

Hum. Cell 15:81-95(2002).

Studies on marker substances in cell lines derived from various human gynecologic tumors.

Sekiya S., Kawata M., Inaba N., Takamizawa H.

Nihon Sanka Fujinka Gakkai Zasshi 34:37-42(1982).

Polymorphic enzyme analysis of cultured human tumor cell lines.";

Dracopoli N.C., Fogh J.

J. Natl. Cancer Inst. 70:469-476(1983).

Effect of anticancer drugs on in vitro survival of cell lines derived from various gynecologic tumors.

Sekiya S., Takamizawa H.

Nihon Sanka Fujinka Gakkai Zasshi 33:373-376(1981).

Studies of the growth and cytogenetic properties of human endometrial adenocarcinoma in culture and its development into an established line.

Kuramoto H.

Acta Obstet. Gynaecol. Jpn. 19:47-58(1972).

Human tumor lines for cancer research.";

Fogh J.

Cancer Invest. 4:157-184(1986).

Absence of HeLa cell contamination in 169 cell lines derived from human tumors.

Fogh J., Wright W.C., Loveless J.D.

J. Natl. Cancer Inst. 58:209-214(1977).

One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.

Fogh J., Fogh J.M., Orfeo T.

J. Natl. Cancer Inst. 59:221-226(1977).

HEC-1 cells: establishment of an in vitro experimental system in endometrial carcinoma.

Kawaguchi M.

(In book chapter) Cell and molecular biology of endometrial carcinoma; Kuramoto H., Nishida M. (eds.); pp.3-34; Springer; Tokyo; Japan (2003).

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