HOSHomo sapiens (Human)Cancer cell line
Quick Overview
Osteosarcoma cell line for cancer research and drug development
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_0312 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Bone, right femur[UBERON:UBERON_0000981] |
Donor Information
| Age | 13 |
|---|---|
| Age Category | Pediatric |
| Sex | Female |
| Race | caucasian |
Disease Information
| Disease | Osteosarcoma |
|---|---|
| Lineage | Bone |
| Subtype | Osteosarcoma |
| OncoTree Code | OS |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-000613_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Arg156Pro (c.467G>C) | Unspecified | - | PubMed=32784519 |
| Gene deletion | CDKN2A | - | Homozygous | Possible | PubMed=26870271 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Characterization of human cancer cell lines by reverse-phase protein arrays.
Liang H.
Cancer Cell 31:225-239(2017).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.
Harris E., Monks A., Morris J.
Mol. Cancer Ther. 14:2452-2462(2015).
Characterization of the metastatic phenotype of a panel of established osteosarcoma cells.
Luu H.H., Meltzer P.S., Khanna C.
Oncotarget 6:29469-29481(2015).
Integrative analysis reveals relationships of genetic and epigenetic alterations in osteosarcoma.
Myklebost O., Meza-Zepeda L.A.
PLoS ONE 7:E48262-E48262(2012).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
Functional characterization of osteosarcoma cell lines provides representative models to study the human disease.
Hogendoorn P.C.W., Llombart-Bosch A., Cleton-Jansen A.-M.
Lab. Invest. 91:1195-1205(2011).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
Molecular characterization of commonly used cell lines for bone tumor research: a trans-European EuroBoNet effort.
Buerger H., Aigner T., Gabbert H.E., Poremba C.
Genes Chromosomes Cancer 49:40-51(2010).
Identification of cryptic microaberrations in osteosarcoma by high-definition oligonucleotide array comparative genomic hybridization.
Squire J.A., Zielenska M.
Cancer Genet. Cytogenet. 179:52-61(2007).
Identification of human autologous cytotoxic T-lymphocyte-defined osteosarcoma gene that encodes a transcriptional regulator, papillomavirus binding factor.
Nagoya S., Wada T., Yamashita T., Sato N.
Cancer Res. 64:5442-5448(2004).
Expression profiling of t(12;22) positive clear cell sarcoma of soft tissue cell lines reveals characteristic up-regulation of potential new marker genes including ERBB3.
Gabbert H.E., Poremba C.
Cancer Res. 64:3395-3405(2004).
Chromosomal alterations in osteosarcoma cell lines revealed by comparative genomic hybridization and multicolor karyotyping.
Poremba C.
Cancer Genet. Cytogenet. 140:145-152(2003).
Differential expression of the amv gene in human hematopoietic cells.
Aaronson S.A., Wong-Staal F.
Proc. Natl. Acad. Sci. U.S.A. 79:2194-2198(1982).
Rearrangement of the p53 gene in human osteogenic sarcomas.";
Masuda H., Miller C., Koeffler H.P., Battifora H.A., Cline M.J.
Proc. Natl. Acad. Sci. U.S.A. 84:7716-7719(1987).
Synergistic killing of virus-transformed human cells with interferon and N-methyl-N'-nitro-N-nitrosoguanidine.
Babich M.A., Day R.S. 3rd
Carcinogenesis 10:265-268(1989).
p53 functions as a cell cycle control protein in osteosarcomas.";
Bressac B., Ozturk M., Baker S.J., Vogelstein B., Friend S.H.
Mol. Cell. Biol. 10:5772-5781(1990).