IMR-32Homo sapiens (Human)Cancer cell line
Also known as: IMR 32, IMR32, Institute for Medical Research-32, GM03320, GM3320C, GM03320D, AG03320, AG3320, IRM-32 (Occasionally.), IMR-92 (Occasionally.)
Quick Overview
Human neuroblastoma cell line with MYCN amplification and chromosomal abnormalities.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_0346 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Abdomen[UBERON:UBERON_0000916] |
Donor Information
| Age | 1 |
|---|---|
| Age Category | Pediatric |
| Sex | Male |
| Race | caucasian |
| Subtype Features | MYC_Amplified |
Disease Information
| Disease | Neuroblastoma |
|---|---|
| Lineage | Peripheral Nervous System |
| Subtype | Neuroblastoma |
| OncoTree Code | NBL |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-000310_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma.
Opoku-Ansah J., Wada R.K., Bachmann A.S., Ramos J.W.
Int. J. Cancer 131:1556-1568(2012).
Cross-contamination meets misclassification: awakening of CHP-100 from sleeping beauty sleep -- a reviewed model for Ewing's sarcoma.
Nagel S., Steenpass L., Becker J.
Int. J. Cancer 148:2608-2613(2021).
Intact-cell MALDI-ToF mass spectrometry for the authentication of drug-adapted cancer cell lines.
Michaelis M.
Cells 8:1194.1-1194.12(2019).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Transcriptomic profiling of 39 commonly-used neuroblastoma cell lines.
Hart L.S., Dent M.H., Fortina P., Reynolds C.P., Maris J.M.
Sci. Data 4:170033-170033(2017).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
A mass spectrometric-derived cell surface protein atlas.";
Aebersold R., Boheler K.R., Zandstra P.W., Wollscheid B.
PLoS ONE 10:E0121314-E0121314(2015).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
A comprehensive transcriptional portrait of human cancer cell lines.
Settleman J., Seshagiri S., Zhang Z.-M.
Nat. Biotechnol. 33:306-312(2015).
Testing of SNS-032 in a panel of human neuroblastoma cell lines with acquired resistance to a broad range of drugs.
Fichtner I., Ghafourian T., Westermann F., Cinatl J. Jr.
Transl. Oncol. 6:685-696(2013).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
Neuroblastoma.";
Thiele C.J.
(In book chapter) Human cell culture. Vol. 1. Cancer cell lines part 1; Masters J.R.W., Palsson B.O. (eds.); pp.21-53; Kluwer Academic Publishers; New York; USA (1999).
Chromosome abnormalities in human tumor cells in culture.";
Biedler J.L.
(In book chapter) Human tumor cells in vitro; Fogh J. (eds.); pp.359-394; Springer; New York; USA (1975).
Homogeneously staining regions and double minute chromosomes, prevalent cytogenetic abnormalities of human neuroblastoma cells.
Biedler J.L., Meyers M.B., Spengler B.A.
(In book chapter) Advances in cellular neurobiology, Vol. 4; Fedoroff S., Hertz L. (eds.); pp.267-307; Academic Press; New York; USA (1983).
Tumor cell lines of the peripheral nervous system.";
Israel M.A., Thiele C.J.
(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.43-78; Academic Press; New York; USA (1994).
A novel chromosome abnormality in human neuroblastoma and antifolate-resistant Chinese hamster cell lives in culture.
Biedler J.L., Spengler B.A.
J. Natl. Cancer Inst. 57:683-695(1976).
Double minute chromosomes and the homogeneously staining regions in chromosomes of a human neuroblastoma cell line.
Balaban-Malenbaum G.B., Gilbert F.
Science 198:739-741(1977).
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
Fogh J., Fogh J.M., Orfeo T.
J. Natl. Cancer Inst. 59:221-226(1977).
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
Fogh J., Wright W.C., Loveless J.D.
J. Natl. Cancer Inst. 58:209-214(1977).
Chromosomal aberrations in human neuroblastomas.";
Brodeur G.M., Sekhon G.S., Goldstein M.N.
Cancer 40:2256-2263(1977).
Phenotypic diversification in human neuroblastoma cells: expression of distinct neural crest lineages.
Ciccarone V.C., Spengler B.A., Meyers M.B., Biedler J.L., Ross R.A.
Cancer Res. 49:219-225(1989).
Inhibition of human melanoma growth by prostaglandin A, D, and J analogues.
Bregman M.D., Funk C., Fukushima M.
Cancer Res. 46:2740-2744(1986).
Definition of a continuous human cell line derived from neuroblastoma.
Tumilowicz J.J., Nichols W.W., Cholon J.J., Greene A.E.
Cancer Res. 30:2110-2118(1970).
Cell culture quality control by rapid isoenzymatic characterization.
Halton D.M., Peterson W.D. Jr., Hukku B.
In Vitro 19:16-24(1983).
Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour.
Gilbert F., Brodeur G.M., Goldstein M.N., Trent J.M.
Nature 305:245-248(1983).
Distinction of seventy-one cultured human tumor cell lines by polymorphic enzyme analysis.
Wright W.C., Daniels W.P., Fogh J.
J. Natl. Cancer Inst. 66:239-247(1981).
Selective toxicity of 6-hydroxydopamine and ascorbate for human neuroblastoma in vitro: a model for clearing marrow prior to autologous transplant.
Reynolds C.P., Reynolds D.A., Frenkel E.P., Smith R.G.
Cancer Res. 42:1331-1336(1982).
Abnormalities of chromosome 1p in human neuroblastoma tumors and cell lines.
Schlesinger H.R.
Cancer Genet. Cytogenet. 7:33-42(1982).
The National Institute on Aging repository cell cultures.";
Das N.K., Murphy D.G.
Mech. Ageing Dev. 16:1-17(1981).
Presence of glycogen and growth-related variations in 58 cultured human tumor cell lines of various tissue origins.
Rousset M., Zweibaum A., Fogh J.
Cancer Res. 41:1165-1170(1981).
Deletion mapping in neuroblastoma cell lines suggests two distinct tumor suppressor genes in the 1p35-36 region, only one of which is associated with N-myc amplification.
Speleman F., Versteeg R.
Oncogene 10:291-297(1995).
Mutations of the p53 gene are involved in Ewing's sarcomas but not in neuroblastomas.
Kamoshita S., Hanada R., Yamamoto K., Hongo T., Yamada M., Tsuchida Y.
Cancer Res. 53:5284-5288(1993).
Neurofibromatosis type 1 gene mutations in neuroblastoma.";
Gusella J.F., Bernards A.
Nat. Genet. 3:62-66(1993).
The p16 and p18 tumor suppressor genes in neuroblastoma: implications for drug resistance.
Diccianni M.B., Chau L.S., Batova A., Vu T.Q., Yu A.L.-T.
Cancer Lett. 104:183-192(1996).
Increased efficacy of aphidicolin killing of human neuroblastoma cells in vitro by encapsulation in liposomes.
Gumbel H.O.C., Rabenau H.F., Kornhuber B., Doerr H.-W.
Neoplasma 44:91-95(1997).
Comparative genomic hybridization analysis of human neuroblastomas: detection of distal 1p deletions and further molecular genetic characterization of neuroblastoma cell lines.
De Paepe A., Cremer T., Speleman F.
Cancer Genet. Cytogenet. 97:135-142(1997).
Analysis of 1;17 translocation breakpoints in neuroblastoma: implications for mapping of neuroblastoma genes.
van der Drift P., Chan A., Versteeg R., Speleman F.
Eur. J. Cancer 33:1974-1978(1997).
Combined M-FISH and CGH analysis allows comprehensive description of genetic alterations in neuroblastoma cell lines.
Salwen H.R., Laureys G., Manoel N., De Paepe A., Speleman F.
Genes Chromosomes Cancer 32:126-135(2001).
Immunocytochemical analysis of cell lines derived from solid tumors.
Quentmeier H., Osborn M., Reinhardt J., Zaborski M., Drexler H.G.
J. Histochem. Cytochem. 49:1369-1378(2001).
Malignant rhabdoid tumor shows incomplete neural characteristics as revealed by expression of SNARE complex.
Yoshida S., Narita T., Taga T., Ohta S., Takeuchi Y.
J. Neurosci. Res. 69:642-652(2002).
PPM1D is a potential target for 17q gain in neuroblastoma.";
Sugimoto T., Inazawa J.
Cancer Res. 63:1876-1883(2003).
Expression profiles and clinical relationships of ID2, CDKN1B, and CDKN2A in primary neuroblastoma.
Gebauer S., Yu A.L.-T., Omura-Minamisawa M., Batova A., Diccianni M.B.
Genes Chromosomes Cancer 41:297-308(2004).
High-resolution detection and mapping of genomic DNA alterations in neuroblastoma.
Maris J.M.
Genes Chromosomes Cancer 43:390-403(2005).
Characterization of a neuronal cell line expressing native human melanin-concentrating hormone receptor 1 (MCHR1).
Frost L.J., McNally T., Reilly R.M., Collins C.A.
Int. J. Biochem. Cell Biol. 38:1290-1299(2006).
Mutations in PIK3CA are infrequent in neuroblastoma.";
Dam V., Morgan B.T., Mazanek P., Hogarty M.D.
BMC Cancer 6:177.1-177.10(2006).
p53 determines multidrug sensitivity of childhood neuroblastoma.";
MacKenzie K.L., Gurova K.V., Norris M.D., Gudkov A.V.
Cancer Res. 67:10351-10360(2007).