JARHomo sapiens (Human)Cancer cell line

Also known as: JaR, JAr, Jar

🤖 AI SummaryBased on 14 publications

Quick Overview

Human choriocarcinoma cell line for cancer research

Detailed Summary

The JAR cell line is a human choriocarcinoma cell line derived from trophoblast cells. It is widely used in research related to placental function, cancer biology, and drug screening. JAR cells exhibit characteristics of trophoblast cells, including hormone production and barrier function. They have been utilized in studies on cell polarity, invasion, and genetic alterations. The cell line is also used to investigate the role of HLA antigens and cell adhesion mechanisms. JAR cells are known for their ability to form spheroids and their utility in three-dimensional organ culture models.

Research Applications

Cancer researchPlacental function studiesDrug screeningCell polarity and adhesionGenetic and molecular studies

Key Characteristics

Hormone productionBarrier functionSpheroid formationHLA antigen expression (limited)Invasion potential

Generated on 6/15/2025

Basic Information

Database ID	CVCL_0360
Species	Homo sapiens (Human)

Donor Information

Age Category	Fetus
Sex	Male

Disease Information

Disease	Gestational choriocarcinoma
Lineage	Uterus
Subtype	Choriocarcinoma
OncoTree Code	UCCA

DepMap Information

Source Type	ATCC
Source ID	ACH-001529_source

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

7,10

D13S317

D16S539

9,10

D18S51

13,17

D19S433

12,13

D21S11

28,29

D2S1338

20,21

D3S1358

D5S818

10,11

D7S820

10,11

D8S1179

14,16

FGA

Penta D

9,11

Penta E

10,12

TH01

6,7

TPOX

8,11

vWA

16,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Cytogenomics of six human trophoblastic cell lines.";

Liehr T., Markert U.R.

Placenta 103:72-75(2021).

DOI PubMed

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A comparative study of five physiological key parameters between four different human trophoblast-derived cell lines.

Rothbauer M., Patel N., Gondola H., Siwetz M., Huppertz B., Ertl P.

Sci. Rep. 7:5892-5892(2017).

DOI PubMed PMC

N-acetylglucosaminyltransferase IVa promotes invasion of choriocarcinoma.

Kikkawa F.

Oncol. Rep. 38:440-448(2017).

DOI PubMed

HTR-8/SVneo cell line contains a mixed population of cells.";

Abou-Kheir W., Barrak J., Hadadeh O., Daoud G.

Placenta 50:1-7(2017).

DOI PubMed

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

A novel feeder-free culture system for human pluripotent stem cell culture and induced pluripotent stem cell derivation.

Trokovic R., Palgi J., Lund R.J., Tuuri T., Otonkoski T.

PLoS ONE 8:E76205-E76205(2013).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Adhesion and invasion of three human choriocarcinoma cell lines into human endometrium in a three-dimensional organ culture system.

Grummer R., Hohn H.-P., Mareel M.M., Denker H.-W.

Placenta 15:411-429(1994).

DOI PubMed

Analysis of the p53 gene in human choriocarcinoma cell lines.";

Yaginuma Y., Yamashita T., Takuma N., Katayama H., Ishikawa M.

Br. J. Cancer 71:9-12(1995).

DOI PubMed PMC

Characterization of cell polarity and epithelial junctions in the choriocarcinoma cell line, JAR.

Mitchell A.M., Yap A.S., Payne E.J., Manley S.W., Mortimer R.H.

Placenta 16:31-39(1995).

DOI PubMed

Cytogenetic analysis of choriocarcinoma cell lines.";

Ohkawa K.

Nihon Sanka Fujinka Gakkai Zasshi 34:2253-2256(1982).

PubMed

Karyotypic analysis and chromosome polymorphisms in four choriocarcinoma cell lines.

Sheppard D.M., Fisher R.A., Lawler S.D.

Cancer Genet. Cytogenet. 16:251-258(1985).

DOI PubMed

Human tumor lines for cancer research.";

Fogh J.

Cancer Invest. 4:157-184(1986).

DOI PubMed

Expression of HLA class I and class II antigens in human choriocarcinoma cell lines.

Yamashita K., Nakamura T., Shimizu T., Katagiri M., Ikeda H.

Int. J. Gynaecol. Obstet. 24:301-307(1986).

DOI PubMed

Chromosomal rearrangement in choriocarcinoma cell lines.";

Surti U., Habibian R.

Cancer Genet. Cytogenet. 38:229-240(1989).

DOI PubMed

The JAr cell line -- continuous human multihormone production and controls.

Pattillo R.A., Ruckert A.C.F., Hussa R.O., Bernstein R., Delfs E.M.

In Vitro 6:398-399(1971).

DOI

Choriocarcinoma.";

Ganapathy V., Prasad P.D., Leibach F.H.

(In book chapter) Human cell culture. Vol. 2. Cancer cell lines part 2; Masters J.R.W., Palsson B.O. (eds.); pp.141-147; Kluwer Academic Publishers; New York; USA (1999).

DOI