JEG-3Homo sapiens (Human)Cancer cell line
Also known as: jeg3, Jeg3, JEG3, Jeg-3
Quick Overview
Human choriocarcinoma cell line used in cancer research.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_0363 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Fetal brain[UBERON:UBERON_0006238] |
Donor Information
| Age Category | Fetus |
|---|---|
| Sex | Male |
Disease Information
| Disease | Gestational choriocarcinoma |
|---|---|
| Lineage | Uterus |
| Subtype | Choriocarcinoma |
| OncoTree Code | UCCA |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-001530_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
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Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Molecular characteristics of established trophoblast-derived cell lines.
Morales-Prieto D.M.
Placenta 108:122-133(2021).
Cytogenomics of six human trophoblastic cell lines.";
Liehr T., Markert U.R.
Placenta 103:72-75(2021).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
A comparative study of five physiological key parameters between four different human trophoblast-derived cell lines.
Rothbauer M., Patel N., Gondola H., Siwetz M., Huppertz B., Ertl P.
Sci. Rep. 7:5892-5892(2017).
HTR-8/SVneo cell line contains a mixed population of cells.";
Abou-Kheir W., Barrak J., Hadadeh O., Daoud G.
Placenta 50:1-7(2017).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
Microarray analysis of BeWo and JEG3 trophoblast cell lines: identification of differentially expressed transcripts.
Grendell R.L., Magness R.R., Golos T.G.
Placenta 28:383-389(2007).
The melanocyte inducing factor MITF is stably expressed in cell lines from human clear cell sarcoma.
Hiraga H., Nojima T., Nagashima K., Schaefer K.-L., Lee K.A.W.
Br. J. Cancer 89:1072-1078(2003).
Human choriocarcinoma cell line JEG-3 produces and secretes active retinoids from retinol.
Sapin V.
Mol. Hum. Reprod. 8:485-493(2002).
Adhesion and invasion of three human choriocarcinoma cell lines into human endometrium in a three-dimensional organ culture system.
Grummer R., Hohn H.-P., Mareel M.M., Denker H.-W.
Placenta 15:411-429(1994).
Analysis of the p53 gene in human choriocarcinoma cell lines.";
Yaginuma Y., Yamashita T., Takuma N., Katayama H., Ishikawa M.
Br. J. Cancer 71:9-12(1995).
Promoters containing ATF-binding sites are de-regulated in cells that express the EWS/ATF1 oncogene.
Brown A.D., Lopez-Terrada D.H., Denny C.T., Lee K.A.W.
Oncogene 10:1749-1756(1995).
Presence of glycogen and growth-related variations in 58 cultured human tumor cell lines of various tissue origins.
Rousset M., Zweibaum A., Fogh J.
Cancer Res. 41:1165-1170(1981).
Polymorphic enzyme analysis of cultured human tumor cell lines.";
Dracopoli N.C., Fogh J.
J. Natl. Cancer Inst. 70:469-476(1983).
Isolation of hormone-producing clonal lines of human choriocarcinoma.
Kohler P.O., Bridson W.E.
J. Clin. Endocrinol. Metab. 32:683-687(1971).
Expression of HLA class I and class II antigens in human choriocarcinoma cell lines.
Yamashita K., Nakamura T., Shimizu T., Katagiri M., Ikeda H.
Int. J. Gynaecol. Obstet. 24:301-307(1986).
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
Fogh J., Wright W.C., Loveless J.D.
J. Natl. Cancer Inst. 58:209-214(1977).
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
Fogh J., Fogh J.M., Orfeo T.
J. Natl. Cancer Inst. 59:221-226(1977).
Ectopic and eutopic secretion of chorionic gonadotropin and its subunits in vitro: comparison of clonal strains from carcinomas of lung and placenta.
Rosen S.W.
J. Natl. Cancer Inst. 56:911-917(1976).
Choriocarcinoma.";
Ganapathy V., Prasad P.D., Leibach F.H.
(In book chapter) Human cell culture. Vol. 2. Cancer cell lines part 2; Masters J.R.W., Palsson B.O. (eds.); pp.141-147; Kluwer Academic Publishers; New York; USA (1999).