Back to Cell Types

JHH-5Homo sapiens (Human)Cancer cell line

Also known as: Functional Liver Cell-5, FLC5, FLC-5, JHH5, Jhh-5

🤖 AI SummaryBased on 9 publications

Quick Overview

Human hepatocellular carcinoma cell line with known p53 mutations and invasive properties.

Detailed Summary

JHH-5 is a human hepatocellular carcinoma (HCC) cell line derived from liver tissue. It is characterized by the presence of p53 gene mutations, which are frequently associated with cancer progression and poor prognosis. The cell line exhibits invasive properties, as demonstrated by its ability to invade reconstituted extracellular matrix in vitro. JHH-5 has been used in studies investigating the role of matrix metalloproteinases (MMPs) and the hepatocyte growth factor (HGF) in tumor invasion and metastasis. Research on JHH-5 has contributed to understanding the molecular mechanisms underlying HCC aggressiveness and has been utilized in drug sensitivity profiling and cancer biology studies.

Research Applications

Cancer biologyDrug sensitivity profilingInvasion and metastasis studiesMolecular mechanisms of HCC

Key Characteristics

p53 gene mutationsInvasive propertiesExpression of MT1-MMP and u-PAResponse to HGF

Generated on 6/15/2025

Basic Information

Database ID	CVCL_0364
Species	Homo sapiens (Human)
Tissue Source	Liver[UBERON:UBERON_0002107]

Donor Information

Age	50
Age Category	Adult
Sex	Male
Race	asian

Disease Information

Disease	Adult hepatocellular carcinoma
Lineage	Liver
Subtype	Hepatocellular Carcinoma
OncoTree Code	HCC

DepMap Information

Source Type	HSRRB
Source ID	ACH-000734_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Pro190_His193del (c.569_580del12)	Unspecified	-	from parent cell line JHH-5
MutationSimple	TERT	c.1-124C>T (c.228C>T) (C228T)	Unspecified	In promoter	from parent cell line Hep-G2
MutationSimple	AXIN1	p.Gln6Argfs*22 (c.17_18delAG)	Unspecified	-	from parent cell line JHH-5

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

9

D13S317

9

D16S539

9,10

D18S51

13

D21S11

31.2

D3S1358

15,17

D5S818

13

D7S820

10,12

D8S1179

12

FGA

19

Penta D

11

Penta E

17,20

TH01

9

TPOX

11

vWA

17,19

Gene Expression Profile

Gene expression levels and statistical distribution

Loading cohorts...

Full DepMap dataset with combined data across cell lines

Loading gene expression data...

Publications

Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins.

Hong W.-J., Fu N.-Y.

Cell Rep. 42:112065.1-112065.26(2023).

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.

van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.

Nat. Commun. 10:3574.1-3574.11(2019).

A pharmacogenomic landscape in human liver cancers.";

Hui L.-J.

Cancer Cell 36:179-193.e11(2019).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

Analysis of liver cancer cell lines identifies agents with likely efficacy against hepatocellular carcinoma and markers of response.

Couchy G., Calderaro J., Nault J.-C., Zucman-Rossi J., Rebouissou S.

Gastroenterology 157:760-776(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

Genomic landscape of copy number aberrations enables the identification of oncogenic drivers in hepatocellular carcinoma.

Xu J.-C.

Hepatology 58:706-717(2013).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

A comprehensive gene expression analysis of human hepatocellular carcinoma cell lines as components of a bioartificial liver using a radial flow bioreactor.

Kosuge M., Takizawa H., Maehashi H., Matsuura T., Matsufuji S.

Liver Int. 27:101-108(2007).

Invasiveness of hepatocellular carcinoma cell lines: contribution of membrane-type 1 matrix metalloproteinase.

Nagamori S., Yamada Y., Saiki I.

Neoplasia 1:424-430(1999).

Yeast functional assay of the p53 gene status in 11 cell lines and 26 surgical specimens of human hepatocellular carcinoma.

Gao C., Ohashi R., Pu H., Inoue Y., Tsuji T., Miyazaki M., Namba M.

Oncol. Rep. 6:1267-1271(1999).

Yeast functional assay of the p53 gene status in human cell lines maintained in our laboratory.

Fukaya K.-i., Ishioka C., Namba M.

Acta Med. Okayama 51:261-265(1997).

Persistence of hepatitis C virus RNA in established human hepatocellular carcinoma cell lines.

Kosaka T., Tsuji T., Namba M.

J. Med. Virol. 48:133-140(1996).

Integration of hepatitis B virus DNA into cells of six established human hepatocellular carcinoma cell lines.

Shimizu K., Niiya M., Kameda H., Fujita K., Ohno T.

Hepato-Gastroenterol. 37:457-460(1990).

The p53 gene status and other cellular characteristics of human cell lines maintained in our laboratory.

Ohashi R., Namba M.

Tissue Cult. Res. Commun. 16:173-178(1997).

Web Resources

lccl.zucmanlab.com