KATO IIIHomo sapiens (Human)Cancer cell line
Also known as: Japanese Tissue Culture-28, JTC-28, KATO 3, KatoIII, KATOIII, KATO-III, Kato-III, Kato III
Quick Overview
Human gastric cancer cell line with FGFR2 overexpression and sensitivity to AZD2171.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_0371 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Pleural effusion[UBERON:UBERON_0000175] |
Donor Information
| Age | 57 |
|---|---|
| Age Category | Adult |
| Sex | Male |
| Race | asian |
Disease Information
| Disease | Gastric signet ring cell adenocarcinoma |
|---|---|
| Lineage | Esophagus/Stomach |
| Subtype | Signet Ring Cell Carcinoma of the Stomach |
| OncoTree Code | SSRCC |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-000793_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| Gene deletion | TP53 | - | Homozygous | 2 out of 3 copies | from parent cell line HL-60 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
TDP1 and TOP1 modulation in olaparib-resistant cancer determines the efficacy of subsequent chemotherapy.
Kim T.-Y., Lee K.W., Oh D.-Y., Kim J.-H., Bang Y.-J.
Cancers (Basel) 12:334.1-334.17(2020).
Quantitative proteomics of the Cancer Cell Line Encyclopedia.";
Sellers W.R., Gygi S.P.
Cell 180:387-402.e16(2020).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.
Nature 568:511-516(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Forty-nine gastric cancer cell lines with integrative genomic profiling for development of c-MET inhibitor.
Kragh M., Horak I.D., Chung H.C., Rha S.Y.
Int. J. Cancer 143:151-159(2018).
Characterization of human cancer cell lines by reverse-phase protein arrays.
Liang H.
Cancer Cell 31:225-239(2017).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
OncoImmunology 3:e954893.1-e954893.12(2014).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
A comprehensive transcriptional portrait of human cancer cell lines.
Settleman J., Seshagiri S., Zhang Z.-M.
Nat. Biotechnol. 33:306-312(2015).
Molecular integrative clustering of Asian gastric cell lines revealed two distinct chemosensitivity clusters.
Yang H.H., Lee M.A.
PLoS ONE 9:E111146-E111146(2014).
Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.
Firestein R., Zhang Z.-M.
Nat. Commun. 5:3830.1-3830.8(2014).
A compensatory role of NF-kappaB to p53 in response to 5-FU-based chemotherapy for gastric cancer cell lines.
Sato K., Iwaya T., Koeda K., Wakabayashi G.
PLoS ONE 9:E90155-E90155(2014).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
AZD2171 shows potent antitumor activity against gastric cancer over-expressing fibroblast growth factor receptor 2/keratinocyte growth factor receptor.
Yamada Y., Tamura T., Fukuoka K., Kimura H., Saijo N., Nishio K.
Clin. Cancer Res. 13:3051-3057(2007).
Screening of DNA copy-number aberrations in gastric cancer cell lines by array-based comparative genomic hybridization.
Okanoue T., Inazawa J.
Cancer Sci. 96:100-110(2005).
Alpha-fetoprotein producing gastric cancer lacks transcription factor ATBF1.
Nakabayashi H., Kawaguchi M., Asai K., Kato T., Itoh M.
Oncogene 20:869-873(2001).
Molecular characteristics of eight gastric cancer cell lines established in Japan.
Yokozaki H.
Pathol. Int. 50:767-777(2000).
Screening the p53 status of human cell lines using a yeast functional assay.
Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Mol. Carcinog. 19:243-253(1997).
Expression of bone morphogenetic proteins of human neoplastic epithelial cells.
Hatakeyama S., Gao Y.-H., Ohara-Nemoto Y., Kataoka H., Satoh M.
Biochem. Mol. Biol. Int. 42:497-505(1997).
HLA-A locus-restricted and tumor-specific CTLs in tumor-infiltrating lymphocytes of patients with non-small cell lung cancer.
Seki N., Hoshino T., Kikuchi M., Hayashi A., Itoh K.
Cell. Immunol. 175:101-110(1997).
Thromboplastic and fibrinolytic activities of cultured human gastric cancer cell lines.
Naito S., Inoue S., Kinjo M., Tanaka K.
Gann 74:240-247(1983).
Comparison of seven cell lines derived from human gastric carcinomas.
Motoyama T., Hojo H., Watanabe H.
Acta Pathol. Jpn. 36:65-83(1986).
p53 gene mutations in gastric cancer metastases and in gastric cancer cell lines derived from metastases.
Nakatani K., Nakano H., Sugimura T., Terada M.
Cancer Res. 51:5800-5805(1991).
Aberrant elevation of tyrosine-specific phosphorylation in human gastric cancer cells.
Ohnishi Y., Xiao H.-Y., Nagai Y., Takagi H.
Jpn. J. Cancer Res. 82:1428-1435(1991).
Missense mutations and a deletion of the p53 gene in human gastric cancer.
Wada K., Uchida T., Nishisaki H., Nagao M., Kasuga M.
Biochem. Biophys. Res. Commun. 182:215-223(1992).
Establishment of cultured cell lines derived from a human gastric carcinoma.
Sekiguchi M., Sakakibara K., Fujii G.
Jpn. J. Exp. Med. 48:61-68(1978).
Operation of the JCRB cell bank and isoenzyme.";
Mizusawa H.
Seibutsu Butsuri Kagaku 34:289-292(1990).
Gastric tumor cell lines.";
Sekiguchi M., Suzuki T.
(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.287-316; Academic Press; New York; USA (1994).