KNS-42Homo sapiens (Human)Cancer cell line

Also known as: KNS42

🤖 AI SummaryBased on 9 publications

Quick Overview

Human glioblastoma cell line for cancer research

Detailed Summary

KNS-42 is a human glioblastoma cell line derived from a malignant glioma. It expresses glial markers such as GFAP, S-100, vimentin, and nestin, and has been used in studies related to glioma biology, drug sensitivity, and tumor angiogenesis. The cell line has been characterized for its genomic alterations, including copy number variations and mutations, and has been utilized in preclinical studies for developing targeted therapies. KNS-42 is also noted for its ability to form tumors in immunodeficient mice, making it a valuable model for in vivo studies.

Research Applications

Cancer researchDrug sensitivity studiesTumor angiogenesisGenomic profiling

Key Characteristics

Expresses glial markers (GFAP, S-100, vimentin)Used in preclinical drug developmentForms tumors in immunodeficient miceGenomic alterations include copy number variations and mutations

Generated on 6/15/2025

Basic Information

Database ID	CVCL_0378
Species	Homo sapiens (Human)
Tissue Source	Brain, right fronto-parietal lobe

Donor Information

Age	16
Age Category	Pediatric
Sex	Male

Disease Information

Disease	Glioblastoma
Lineage	CNS/Brain
Subtype	Glioblastoma
OncoTree Code	GB

DepMap Information

Source Type	HSRRB
Source ID	ACH-000622_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg342Ter (c.1024C>T)	Homozygous	-	PubMed=29970484
MutationSimple	BLM	p.Ser186_Lys187delinsTer (c.557_559delCAA) (S186*)	Heterozygous	-	Unknown, Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D10S1248

13,14

D12S391

D13S317

D16S539

9,12

D18S51

13,15

D19S433

D1S1656

D21S11

30,32

D22S1045

D2S1338

17,20

D2S441

D3S1358

D5S818

D7S820

8,11

D8S1179

FGA

21.2,24

Penta D

9,11

Penta E

12,20

TH01

TPOX

8,11

vWA

18,19

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

DOI PubMed

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

Cell migration in paediatric glioma; characterisation and potential therapeutic targeting.

Short S., Steel L.P., Melcher A., Lawler S.E., Bruning-Richardson A.

Br. J. Cancer 112:693-703(2015).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Molecular and phenotypic characterisation of paediatric glioma cell lines as models for preclinical drug development.

Jones C.

PLoS ONE 4:E5209-E5209(2009).

DOI PubMed PMC

Overexpressed Skp2 within 5p amplification detected by array-based comparative genomic hybridization is associated with poor prognosis of glioblastomas.

Aoyagi M., Ohno K., Imoto I., Inazawa J.

Cancer Sci. 96:676-683(2005).

DOI PubMed PMC

Characteristics of an established human glioma cell line, KNS-42.";

Ogawa H., Egami H., Mannoji H., Fukui M., Kitamura K.

Neurol. Med. Chir. (Tokyo) 27:581-587(1987).

DOI PubMed