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LAMA-84Homo sapiens (Human)Cancer cell line

Also known as: Lama84, LAMA84, Lama-84

🤖 AI SummaryBased on 12 publications

Quick Overview

Human leukemia cell line with potential for differentiation studies.

Detailed Summary

LAMA-84 is a human leukemia cell line derived from a patient with chronic myeloid leukemia in the acute phase. It exhibits characteristics of megakaryocytic, erythroid, and granulocytic lineages, making it a valuable model for studying hematopoietic differentiation. The cell line expresses markers for basophils and mast cells, including the high-affinity IgE receptor and tryptase. It is also used in research on the JAK2 V617F mutation, which is associated with myeloproliferative disorders. LAMA-84 has been utilized in studies involving drug sensitivity profiling and genetic analysis to understand cancer progression and therapeutic responses.

Research Applications

Hematopoietic differentiation studiesJAK2 V617F mutation analysisDrug sensitivity profilingGenetic and molecular characterization of leukemia

Key Characteristics

Expresses megakaryocytic, erythroid, and granulocytic markersShows basophil and mast cell-like characteristicsCarries the JAK2 V617F mutationUsed in studies of myeloproliferative disorders

Generated on 6/15/2025

Basic Information

Database ID	CVCL_0388
Species	Homo sapiens (Human)
Tissue Source	Peripheral blood[UBERON:UBERON_0000178]

Donor Information

Age	29
Age Category	Adult
Sex	Female
Subtype Features	BCR-ABL1 positive

Disease Information

Disease	Chronic myeloid leukemia
Lineage	Myeloid
Subtype	Chronic Myeloid Leukemia, BCR-ABL1+
OncoTree Code	CMLBCRABL1

DepMap Information

Source Type	DSMZ
Source ID	ACH-000301_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Lys319Ter (c.955A>T)	Homozygous	-	from parent cell line LAMA-84
Gene fusion	ABL1	BCR-ABL1, BCR-ABL	-	BCR exon 1 fused to ABL1 exon 2	PubMed=10576511, PubMed=10071072, PubMed=8751477

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

8,11,12

D12S391

18,24

D13S317

11

D16S539

11

D18S51

13

D19S433

13

D1S1656

15,15.3

D21S11

29,30,31

D2S1338

17

D3S1358

14,17

D5S818

11,12

D6S1043

10,20

D7S820

11

D8S1179

10,15

FGA

21,22

Penta D

10

Penta E

7

TH01

6,7

TPOX

10

vWA

14,17

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

The LL-100 panel: 100 cell lines for blood cancer studies.";

MacLeod R.A.F., Nagel S., Steube K.G., Uphoff C.C., Drexler H.G.

Sci. Rep. 9:8218-8218(2019).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Golub T.R., Root D.E., Hahn W.C.

Sci. Data 1:140035-140035(2014).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Genomic amplification of BCR/ABL1 and a region downstream of ABL1 in chronic myeloid leukaemia: a FISH mapping study of CML patients and cell lines.

Virgili A., Nacheva E.

Mol. Cytogenet. 3:15.1-15.12(2010).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.

Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.

Leukemia 20:471-476(2006).

Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.

Fioretos T.

Leukemia 19:1042-1050(2005).

ABL-BCR expression in BCR-ABL-positive human leukemia cell lines.";

Uphoff C.C., Habig S., Fombonne S., Matsuo Y., Drexler H.G.

Leuk. Res. 23:1055-1060(1999).

Leukemia cell lines: in vitro models for the study of Philadelphia chromosome-positive leukemia.

Drexler H.G., MacLeod R.A.F., Uphoff C.C.

Leuk. Res. 23:207-215(1999).

Proliferation of LAMA-84 and LAMA-87 cell lines is modulated by autocrine loops involving M-CSF and TGF-beta.

Seigneurin D.

Exp. Hematol. 25:958-965(1997).

Characterization of a human basophil-like cell line (LAMA-84).";

Blom T., Nilsson G., Sundstrom C., Nilsson K., Hellman L.

Scand. J. Immunol. 44:54-61(1996).

Selection and characterization of an erythroeosinophilic subclone (LAMA-87) and an eosinophilic subclone (LAMA-88) from the multipotential cell line LAMA-84.

Champelovier P., Valiron O., Jacrot M., Leroux D., Seigneurin D.

Leuk. Res. 18:903-918(1994).

Human chronic myeloid leukemic cell line with positive Philadelphia chromosome exhibits megakaryocytic and erythroid characteristics.

Pietrantuono A., Kolodie L.

Exp. Hematol. 15:822-832(1987).

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).