LN-18Homo sapiens (Human)Cancer cell line

Also known as: LN018, LN18, LN 18

🤖 AI SummaryBased on 12 publications

Quick Overview

LN-18 is a human glioblastoma cell line used in cancer research.

Detailed Summary

LN-18 is a human glioblastoma cell line derived from a brain tumor. It is widely used in research to study the molecular mechanisms of glioblastoma and to test potential therapeutic strategies. The cell line has been characterized for its genetic alterations, including mutations in the TP53, PTEN, and p16/ARF genes. LN-18 cells are known for their resistance to certain chemotherapeutic agents and have been used to investigate multidrug resistance mechanisms. Additionally, the cell line has been utilized in studies related to the p53 pathway and its role in cell death and survival. Research on LN-18 has contributed to understanding the genetic and molecular basis of glioblastoma progression and treatment resistance.

Research Applications

Cancer researchMolecular mechanisms of glioblastomaTherapeutic strategy testingMultidrug resistance studiesp53 pathway investigation

Key Characteristics

TP53 mutationPTEN mutationp16/ARF deletionResistance to chemotherapeutic agentsUsed in p53 functional assays

Generated on 6/15/2025

Basic Information

Database ID	CVCL_0392
Species	Homo sapiens (Human)
Tissue Source	Brain, right temporal lobe[UBERON:UBERON_0002809]

Donor Information

Age	65
Age Category	Adult
Sex	Male
Race	caucasian

Disease Information

Disease	Glioblastoma
Lineage	CNS/Brain
Subtype	Glioblastoma
OncoTree Code	GB

DepMap Information

Source Type	ATCC
Source ID	ACH-000819_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Cys238Ser (c.713G>C)	Heterozygous	-	Unknown
MutationSimple	PIK3CB	p.Glu1051Lys (c.3151G>A)	Homozygous	-	PubMed=38573494
Gene deletion	CDKN2A	-	Homozygous	Possible	PubMed=26870271

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

D13S317

12,13

D16S539

11,13

D18S51

17,19

D19S433

12,15

D21S11

D2S1338

17,20

D3S1358

15,16

D5S818

11,13

D7S820

8,10

D8S1179

12,14

FGA

19,23

Penta D

Penta E

7,10

TH01

TPOX

vWA

17,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

Elucidating the cancer-specific genetic alteration spectrum of glioblastoma derived cell lines from whole exome and RNA sequencing.

Patil V., Pal J., Somasundaram K.

Oncotarget 6:43452-43471(2015).

DOI PubMed PMC

A mass spectrometric-derived cell surface protein atlas.";

Aebersold R., Boheler K.R., Zandstra P.W., Wollscheid B.

PLoS ONE 10:E0121314-E0121314(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

DNA fingerprinting of glioma cell lines and considerations on similarity measurements.

Hamou M.-F., Delorenzi M., Hegi M.E.

Neuro-oncol. 14:701-711(2012).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

MAP kinase-interacting kinase 1 regulates SMAD2-dependent TGF-beta signaling pathway in human glioblastoma.

Moncayo G., Hemmings B.A.

Cancer Res. 71:2392-2402(2011).

DOI PubMed

Mechanisms of resistance of human glioma cells to Apo2 ligand/TNF-related apoptosis-inducing ligand.

Rieger J., Frank B., Weller M., Wick W.

Cell. Physiol. Biochem. 20:23-34(2007).

DOI PubMed

P-glycoprotein and multidrug resistance-associated protein mediate specific patterns of multidrug resistance in malignant glioma cell lines, but not in primary glioma cells.

Bahr O., Rieger J., Duffner F., Meyermann R., Weller M., Wick W.

Brain Pathol. 13:482-494(2003).

DOI PubMed PMC

CP-31398, a novel p53-stabilizing agent, induces p53-dependent and p53-independent glioma cell death.

Wischhusen J., Naumann U., Ohgaki H., Rastinejad F., Weller M.

Oncogene 22:8233-8245(2003).

DOI PubMed

Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines.

Van Meir E.G.

Brain Pathol. 9:469-479(1999).

DOI PubMed PMC

Predicting chemoresistance in human malignant glioma cells: the role of molecular genetic analyses.

Krajewski S., Reed J.C., von Deimling A., Dichgans J.

Int. J. Cancer 79:640-644(1998).

DOI PubMed

The human melanoma antigen-encoding gene, MAGE-1, is expressed by other tumour cells of neuroectodermal origin such as glioblastomas and neuroblastomas.

Rimoldi D., Romero P., Carrel S.

Int. J. Cancer 54:527-528(1993).

DOI PubMed

A simple p53 functional assay for screening cell lines, blood, and tumors.

Tada M., Van Meir E.G., Estreicher A., Iggo R.D.

Proc. Natl. Acad. Sci. U.S.A. 92:3963-3967(1995).

DOI PubMed PMC

Variant CD44 adhesion molecules are expressed in human brain metastases but not in glioblastomas.

Diserens A.-C., Van Meir E.G.

Cancer Res. 53:5345-5349(1993).

PubMed

Characterization of an established human malignant glioma cell line: LN-18.

Schnegg J.-F., Carrel S.

Acta Neuropathol. 53:21-28(1981).

DOI PubMed

Brain tumors.";

Ali-Osman F.

(In book chapter) Human cell culture. Vol. 2. Cancer cell lines part 2; Masters J.R.W., Palsson B.O. (eds.); pp.167-184; Kluwer Academic Publishers; New York; USA (1999).

DOI