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MEG-01Homo sapiens (Human)Cancer cell line

Also known as: Meg01, MEG01, Meg-01, Mego-1 (Occasionally.)

🤖 AI SummaryBased on 14 publications

Quick Overview

MEG-01 is a CML cell line used in research for leukemia and cancer studies.

Detailed Summary

MEG-01 is a chronic myeloid leukemia (CML) cell line derived from a patient in blast crisis. It is widely used in research for studying the molecular mechanisms of CML, including the BCR-ABL fusion gene and its role in leukemogenesis. This cell line is also utilized in investigations related to drug resistance, particularly to tyrosine kinase inhibitors. MEG-01 cells are known for their ability to differentiate into megakaryocytes and platelet-like particles, making them valuable for studies on platelet function and calcium signaling. The cell line has been involved in studies examining the effects of Valproic acid on differentiation and the role of Notch3 in megakaryopoiesis. Additionally, MEG-01 is used in genomic studies to understand the amplification of BCR-ABL and its implications in disease progression.

Research Applications

Leukemia researchCancer studiesDrug resistancePlatelet functionGenomic amplificationDifferentiation studies

Key Characteristics

BCR-ABL fusion geneTyrosine kinase activityDifferentiation into megakaryocytesPlatelet-like particle formationGenomic instabilityResistance to tyrosine kinase inhibitors

Generated on 6/15/2025

Basic Information

Database ID	CVCL_0425
Species	Homo sapiens (Human)
Tissue Source	Bone marrow[UBERON:UBERON_0002371]

Donor Information

Age	55
Age Category	Adult
Sex	Male

Disease Information

Disease	Chronic myeloid leukemia
Lineage	Myeloid
Subtype	Chronic Myeloid Leukemia, BCR-ABL1+
OncoTree Code	CMLBCRABL1

DepMap Information

Source Type	ATCC
Source ID	ACH-000072_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.His233del (c.697_699delCAC)	Heterozygous	-	from parent cell line MEG-01s
MutationSimple	ASXL1	p.Gly646Trpfs*12 (c.1934dupG)	Heterozygous	-	from parent cell line MEG-01s
Gene fusion	ABL1	BCR-ABL1, BCR-ABL	-	BCR exon 1 fused to ABL1 exon 2	PubMed=10576511, PubMed=10071072, PubMed=8751477

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

10

D13S317

8

D16S539

9

D18S51

18,22

D19S433

14,16

D21S11

29

D2S1338

19

D3S1358

15

D5S818

13

D7S820

11

D8S1179

14,15

FGA

26

Penta D

11,13

Penta E

15

TH01

7

TPOX

8,11

vWA

16

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Establishment of a megakaryoblastic cell line for conventional assessment of platelet calcium signaling.

Yatomi Y., Ohmori T.

Int. J. Hematol. 111:786-794(2020).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

Regulation of differentiation of MEG01 to megakaryocytes and platelet-like particles by valproic acid through Notch3 mediated actin polymerization.

Dhenge A., Kuhikar R., Kale V., Limaye L.S.

Platelets 30:780-795(2019).

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

Transcriptomic analysis of the ion channelome of human platelets and megakaryocytic cell lines.

Wright J.R., Amisten S., Goodall A.H., Mahaut-Smith M.P.

Thromb. Haemost. 116:272-284(2016).

Truncation mutants of ASXL1 observed in myeloid malignancies are expressed at detectable protein levels.

Kitamura T.

Exp. Hematol. 44:172-176.e1(2016).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Genomic amplification of BCR/ABL1 and a region downstream of ABL1 in chronic myeloid leukaemia: a FISH mapping study of CML patients and cell lines.

Virgili A., Nacheva E.

Mol. Cytogenet. 3:15.1-15.12(2010).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.

Fioretos T.

Leukemia 19:1042-1050(2005).

ABL-BCR expression in BCR-ABL-positive human leukemia cell lines.";

Uphoff C.C., Habig S., Fombonne S., Matsuo Y., Drexler H.G.

Leuk. Res. 23:1055-1060(1999).

Leukemia cell lines: in vitro models for the study of Philadelphia chromosome-positive leukemia.

Drexler H.G., MacLeod R.A.F., Uphoff C.C.

Leuk. Res. 23:207-215(1999).

Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia.

Aizawa Y., Ueda R., Seto M.

Jpn. J. Cancer Res. 89:712-718(1998).

Ph positive CML cell lines.";

Keating A.

Baillieres Clin. Haematol. 1:1021-1029(1987).

Establishment of a novel human megakaryoblastic leukemia cell line, MEG-01, with positive Philadelphia chromosome.

Saito H.

Blood 66:1384-1392(1985).

Aphidicolin, an inhibitor of DNA replication, blocks the TPA-induced differentiation of a human megakaryoblastic cell line, MEG-O1.

Saito H., Yoshida S.

Blood 78:3168-3177(1991).

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).