MKN45Homo sapiens (Human)Cancer cell line
Also known as: MKN-45, MKN 45, NKM45 (Occasionally.), NKM-45 (Occasionally.), MNK45 (Occasionally.), MNK-45 (Occasionally.), MKN46
Quick Overview
Human gastric cancer cell line with diverse research applications.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_0434 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Liver[UBERON:UBERON_0002107] |
Donor Information
| Age | 62 |
|---|---|
| Age Category | Adult |
| Sex | Female |
| Race | asian |
Disease Information
| Disease | Gastric adenocarcinoma |
|---|---|
| Lineage | Esophagus/Stomach |
| Subtype | Diffuse Type Stomach Adenocarcinoma |
| OncoTree Code | DSTAD |
DepMap Information
| Source Type | HSRRB |
|---|---|
| Source ID | ACH-000356_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Arg110Cys (c.328C>T) | Heterozygous | - | PubMed=29970484 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Characterization of human cancer cell lines by reverse-phase protein arrays.
Liang H.
Cancer Cell 31:225-239(2017).
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Quantitative proteomics of the Cancer Cell Line Encyclopedia.";
Sellers W.R., Gygi S.P.
Cell 180:387-402.e16(2020).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Forty-nine gastric cancer cell lines with integrative genomic profiling for development of c-MET inhibitor.
Kragh M., Horak I.D., Chung H.C., Rha S.Y.
Int. J. Cancer 143:151-159(2018).
Gastric tumor cell lines.";
Sekiguchi M., Suzuki T.
(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.287-316; Academic Press; New York; USA (1994).
Nrf2-ME-1 axis is associated with 5-FU resistance in gastric cancer cell line.
Pouremamali F., Jeddi F., Samadi N.
Process Biochem. 114:174-184(2022).
Thromboplastic and fibrinolytic activities of cultured human cancer cell lines.
Yasumoto K.
Br. J. Cancer 39:15-23(1979).
Missense mutations and a deletion of the p53 gene in human gastric cancer.
Wada K., Uchida T., Nishisaki H., Nagao M., Kasuga M.
Biochem. Biophys. Res. Commun. 182:215-223(1992).
Karyotypic analysis of gastric carcinoma cell lines carrying an amplified c-met oncogene.
Comoglio P.M., Saglio G.
Cancer Genet. Cytogenet. 64:170-173(1992).
Aberrant elevation of tyrosine-specific phosphorylation in human gastric cancer cells.
Ohnishi Y., Xiao H.-Y., Nagai Y., Takagi H.
Jpn. J. Cancer Res. 82:1428-1435(1991).
Co-stimulation of gastrointestinal tumour cell growth by gastrin, transforming growth factor alpha and insulin like growth factor-I.
Durrant L.G., Watson S.A., Hall A., Morris D.L.
Br. J. Cancer 63:67-70(1991).
p53 gene mutations in gastric cancer metastases and in gastric cancer cell lines derived from metastases.
Nakatani K., Nakano H., Sugimura T., Terada M.
Cancer Res. 51:5800-5805(1991).
Intracellular gastrin in human gastrointestinal tumor cells.";
Watson S.A., Durrant L.G., Wencyk P.M., Watson A.L., Morris D.L.
J. Natl. Cancer Inst. 83:866-871(1991).
The effect of the E2 prostaglandin enprostil, and the somatostatin analogue SMS 201 995, on the growth of a human gastric cell line, MKN45G.
Watson S.A., Durrant L.G., Morris D.L.
Int. J. Cancer 45:90-94(1990).
Comparison of seven cell lines derived from human gastric carcinomas.
Motoyama T., Hojo H., Watanabe H.
Acta Pathol. Jpn. 36:65-83(1986).
Analysis of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced DNA damage in tumor cell strains from Japanese patients and demonstration of MNNG hypersensitivity of Mer xenografts in athymic nude mice.
Kondo S.
Carcinogenesis 6:549-553(1985).
Thromboplastic and fibrinolytic activities of cultured human gastric cancer cell lines.
Naito S., Inoue S., Kinjo M., Tanaka K.
Gann 74:240-247(1983).
HLA-A locus-restricted and tumor-specific CTLs in tumor-infiltrating lymphocytes of patients with non-small cell lung cancer.
Seki N., Hoshino T., Kikuchi M., Hayashi A., Itoh K.
Cell. Immunol. 175:101-110(1997).
Expression of bone morphogenetic proteins of human neoplastic epithelial cells.
Hatakeyama S., Gao Y.-H., Ohara-Nemoto Y., Kataoka H., Satoh M.
Biochem. Mol. Biol. Int. 42:497-505(1997).
Screening the p53 status of human cell lines using a yeast functional assay.
Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Mol. Carcinog. 19:243-253(1997).
Activation of the urokinase plasminogen activator/urokinase plasminogen activator receptor system and redistribution of E-cadherin are associated with hepatocyte growth factor-induced motility of pancreas tumor cells overexpressing Met.
Real F.X.
Am. J. Pathol. 153:201-212(1998).
Molecular characteristics of eight gastric cancer cell lines established in Japan.
Yokozaki H.
Pathol. Int. 50:767-777(2000).
Alpha-fetoprotein producing gastric cancer lacks transcription factor ATBF1.
Nakabayashi H., Kawaguchi M., Asai K., Kato T., Itoh M.
Oncogene 20:869-873(2001).
Immunocytochemical analysis of cell lines derived from solid tumors.
Quentmeier H., Osborn M., Reinhardt J., Zaborski M., Drexler H.G.
J. Histochem. Cytochem. 49:1369-1378(2001).
Screening of DNA copy-number aberrations in gastric cancer cell lines by array-based comparative genomic hybridization.
Okanoue T., Inazawa J.
Cancer Sci. 96:100-110(2005).
Chemosensitivity profile of cancer cell lines and identification of genes determining chemosensitivity by an integrated bioinformatical approach using cDNA arrays.
Yamori T.
Mol. Cancer Ther. 4:399-412(2005).
p53-defective tumors with a functional apoptosome-mediated pathway: a new therapeutic target.
Tomoda H., Yamori T., Tsuruo T.
J. Natl. Cancer Inst. 97:765-777(2005).
Correlation between DNA alterations and p53 and p16 protein expression in cancer cell lines.
Murai Y., Hayashi S., Takahashi H., Tsuneyama K., Takano Y.
Pathol. Res. Pract. 201:109-115(2005).
In vitro pharmacogenomic database and chemosensitivity predictive genes in gastric cancer.
Noh S.H., Rha S.Y.
Genomics 93:52-61(2009).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
JFCR39, a panel of 39 human cancer cell lines, and its application in the discovery and development of anticancer drugs.
Kong D.-X., Yamori T.
Bioorg. Med. Chem. 20:1947-1951(2012).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
Comparison between the gastric cancer cell line MKN-45 and the high-potential peritoneal dissemination gastric cancer cell line MKN-45P.
Koga A., Aoyagi K., Imaizumi T., Miyagi M., Shirouzu K.
Kurume Med. J. 58:73-79(2011).
A novel approach for characterizing microsatellite instability in cancer cells.
Lu Y.-H., Soong T.D., Elemento O.
PLoS ONE 8:E63056-E63056(2013).
A compensatory role of NF-kappaB to p53 in response to 5-FU-based chemotherapy for gastric cancer cell lines.
Sato K., Iwaya T., Koeda K., Wakabayashi G.
PLoS ONE 9:E90155-E90155(2014).
Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.
Firestein R., Zhang Z.-M.
Nat. Commun. 5:3830.1-3830.8(2014).
Molecular integrative clustering of Asian gastric cell lines revealed two distinct chemosensitivity clusters.
Yang H.H., Lee M.A.
PLoS ONE 9:E111146-E111146(2014).
A comprehensive transcriptional portrait of human cancer cell lines.
Settleman J., Seshagiri S., Zhang Z.-M.
Nat. Biotechnol. 33:306-312(2015).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
OncoImmunology 3:e954893.1-e954893.12(2014).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).