RajiHomo sapiens (Human)Cancer cell line
Also known as: RAJI, P1-Raji, GM04671, BAJI
Quick Overview
Human B-cell lymphoma cell line used in cancer research.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_0511 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Bone, jaw, maxilla[UBERON:UBERON_0002397] |
Donor Information
| Age | 11 |
|---|---|
| Age Category | Pediatric |
| Sex | Male |
| Race | african |
Disease Information
| Disease | EBV-related Burkitt lymphoma |
|---|---|
| Lineage | Lymphoid |
| Subtype | Burkitt Lymphoma |
| OncoTree Code | BL |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-000654_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| Gene fusion | IGH | MYC-IGH | - | - | PubMed=31160637 |
| MutationSimple | TP53 | p.Arg213Gln (c.638G>A) | Homozygous | - | from parent cell line 1181N1 |
| MutationSimple | TP53 | p.Tyr234His (c.700T>C) | Heterozygous | - | from parent cell line Raji |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Distinct reactivity of Burkitt's lymphoma cell lines with eight monoclonal antibodies correlated with the ethnic origin.
Lenoir G.M.
J. Natl. Cancer Inst. 73:841-847(1984).
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
The LL-100 panel: 100 cell lines for blood cancer studies.";
MacLeod R.A.F., Nagel S., Steube K.G., Uphoff C.C., Drexler H.G.
Sci. Rep. 9:8218-8218(2019).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Screening human cell lines for viral infections applying RNA-Seq data analysis.
Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.
PLoS ONE 14:E0210404-E0210404(2019).
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
Yang H.H., Koeffler H.P.
BMC Cancer 18:940.1-940.13(2018).
Screening for 15 pathogenic viruses in human cell lines registered at the JCRB Cell Bank: characterization of in vitro human cells by viral infection.
Satoh M., Shimizu N., Kohara A.
R. Soc. Open Sci. 5:172472-172472(2018).
Characterization of human cancer cell lines by reverse-phase protein arrays.
Liang H.
Cancer Cell 31:225-239(2017).
Subclones in B-lymphoma cell lines: isogenic models for the study of gene regulation.
Zaborski M., Drexler H.G.
Oncotarget 7:63456-63465(2016).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
OncoImmunology 3:e954893.1-e954893.12(2014).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
A comprehensive transcriptional portrait of human cancer cell lines.
Settleman J., Seshagiri S., Zhang Z.-M.
Nat. Biotechnol. 33:306-312(2015).
High-throughput RNA sequencing-based virome analysis of 50 lymphoma cell lines from the Cancer Cell Line Encyclopedia project.
O'Grady T., Baddoo M., Fewell C., Renne R., Flemington E.K.
J. Virol. 89:713-729(2015).
Comprehensive cytogenetic and molecular cytogenetic analysis of 44 Burkitt lymphoma cell lines: secondary chromosomal changes characterization, karyotypic evolution, and comparison with primary samples.
Vettorazzi E., Bokemeyer C., Dierlamm J.
Genes Chromosomes Cancer 53:497-515(2014).
Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics.
Waldmann T.A., Rowe M., Mbulaiteye S.M., Rickinson A.B., Staudt L.M.
Nature 490:116-120(2012).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
Detection of EBV, HBV, HCV, HIV-1, HTLV-I and -II, and SMRV in human and other primate cell lines.
Uphoff C.C., Denkmann S.A., Steube K.G., Drexler H.G.
J. Biomed. Biotechnol. 2010:904767.1-904767.23(2010).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
Expression of the ULBP ligands for NKG2D by B-NHL cells plays an important role in determining their susceptibility to rituximab-induced ADCC.
Mori F., Ding J.-M., Komatsu H., Iida S., Ueda R.
Int. J. Cancer 125:212-221(2009).
Generation of multidrug resistant lymphoma cell lines stably expressing P-glycoprotein.
Pop I., Pop L., Vitetta E.S., Ghetie M.-A.
Oncol. Rep. 19:889-895(2008).
Correlation between DNA alterations and p53 and p16 protein expression in cancer cell lines.
Murai Y., Hayashi S., Takahashi H., Tsuneyama K., Takano Y.
Pathol. Res. Pract. 201:109-115(2005).
Raji revisited: cytogenetics of the original Burkitt's lymphoma cell line.
Fadeel B.
Leukemia 19:159-161(2005).
Characterization of expression of protein kinase C isozymes in human B-cell lymphoma: relationship between its expression and prognosis.
Kamimura K., Hojo H., Abe M.
Pathol. Int. 54:224-230(2004).
Integration of Epstein-Barr virus into chromosome 6q15 of Burkitt lymphoma cell line (Raji) induces loss of BACH2 expression.
Aozasa K.
Am. J. Pathol. 164:967-974(2004).
Cytology of Burkitt's tumour (African lymphoma).";
Pulvertaft R.J.V.
Lancet 283:238-240(1964).
Comparison of gene expression profiles of lymphoma cell lines from transformed follicular lymphoma, Burkitt's lymphoma and de novo diffuse large B-cell lymphoma.
Maesako Y., Uchiyama T., Ohno H.
Cancer Sci. 94:774-781(2003).
Detection of clonal EBV episomes in lymphoproliferations as a diagnostic tool.
van Dongen J.J.M.
Leukemia 16:1572-1573(2002).
Short tandem repeat profiling provides an international reference standard for human cell lines.
Harrison M., Virmani A.K., Ward T.H., Ayres K.L., Debenham P.G.
Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001).
Corrigendum to: Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines Leukemia Research 24 (2000), 255-262.
Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.
Leuk. Res. 25:275-278(2001).
Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines.
Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.
Leuk. Res. 24:255-262(2000).
Bax is frequently compromised in Burkitt's lymphomas with irreversible resistance to Fas-induced apoptosis.
Magrath I.T., Bhatia K.G.
Cancer Res. 59:696-703(1999).
PTEN gene alterations in lymphoid neoplasms.";
Sakai A., Thieblemont C., Wellmann A., Jaffe E.S., Raffeld M.
Blood 92:3410-3415(1998).
Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia.
Aizawa Y., Ueda R., Seto M.
Jpn. J. Cancer Res. 89:712-718(1998).
The induction of apoptosis and cell cycle arrest by arsenic trioxide in lymphoid neoplasms.
Takeshita K., Takeshita A., Ohno R.
Leukemia 12:1383-1391(1998).
Telomere analysis by fluorescence in situ hybridization and flow cytometry.
Roos G.
Nucleic Acids Res. 26:3651-3656(1998).
Frameshift mutations of the hMSH6 gene in human leukemia cell lines.
Hirai H.
Jpn. J. Cancer Res. 89:33-39(1998).
p16/INK4a and p15/INK4b gene methylation and absence of p16/INK4a mRNA and protein expression in Burkitt's lymphoma.
Klangby U., Okan I., Magnusson K.P., Wendland M., Lind P., Wiman K.G.
Blood 91:1680-1687(1998).
Role of the p53 tumor suppressor gene in the tumorigenicity of Burkitt's lymphoma cells.
Pike S.E., Gupta G., Magrath I.T., Tosato G.
Cancer Res. 57:2508-2515(1997).
Sensitivity to dexamethasone and absence of bcl-2 protein in Burkitt's lymphoma cell line (Black93) derived from a patient with acute tumor lysis syndrome: comparative study with other BL and non-BL lines.
Nakamura H., Amakawa R., Ohno H.
Leukemia 10:1592-1603(1996).
IL-12 expression in AIDS-related lymphoma B cell lines.";
Trinchieri G.
J. Immunol. 156:1626-1637(1996).
Cell surface c-kit receptors in human leukemia cell lines and pediatric leukemia: selective preservation of c-kit expression on megakaryoblastic cell lines during adaptation to in vitro culture.
Imaizumi M., Endo M., Takano N., Konno T.
Leukemia 10:102-105(1996).
Homozygous loss of the MTS1/p16 and MTS2/p15 genes in lymphoma and lymphoblastic leukaemia cell lines.
Uppenkamp M.J., Nowrousian M.R., Seeber S., Opalka B.
Br. J. Haematol. 91:350-354(1995).
Variable IgH chain enhancer activity in Burkitt's lymphomas suggests an additional, direct mechanism of c-myc deregulation.
Jain V.K., Judde J.-G., Max E.E., Magrath I.T.
J. Immunol. 150:5418-5428(1993).
Hemi- or homozygosity: a requirement for some but not other p53 mutant proteins to accumulate and exert a pathogenetic effect.
Magrath I.T.
FASEB J. 7:951-956(1993).
DNA double-strand break rejoining deficiency in TK6 and other human B-lymphoblast cell lines.
Olive P.L.
Radiat. Res. 134:307-315(1993).
B cell IL-7. Human B cell lines constitutively secrete IL-7 and express IL-7 receptors.
Goodwin R.G.
J. Immunol. 152:4749-4757(1994).
Deletions and rearrangement of CDKN2 in lymphoid malignancy.";
Millar J.L., Catovsky D., Dyer M.J.S.
Blood 85:893-901(1995).
Differences in genetic stability between human cell lines from patients with and without lymphoreticular malignancy.
Povey S., Jeremiah S., Arthur E., Steel M., Klein G.
Ann. Hum. Genet. 44:119-133(1980).
Reassociation of human lymphoblastoid cell DNA repair replicated following methyl methanesulfonate treatment.
Meltz M.L., Whittam N.J., Thornburg W.H.
Chem. Biol. Interact. 39:77-88(1982).
Differential expression of the amv gene in human hematopoietic cells.
Aaronson S.A., Wong-Staal F.
Proc. Natl. Acad. Sci. U.S.A. 79:2194-2198(1982).
Correlation between immunoglobulin light chain expression and variant translocation in Burkitt's lymphoma.
Lenoir G.M., Preud'homme J.-L., Bernheim A., Berger R.
Nature 298:474-476(1982).
Growth of human malignant lymphoid cell lines in serum-free medium.";
Uittenbogaart C.H., Cantor Y., Fahey J.L.
In Vitro 19:67-72(1983).
The animal cell culture collection.";
Stulberg C.S., Coriell L.L., Kniazeff A.J., Shannon J.E.
In Vitro 5:1-16(1970).
Enhanced destruction of lymphoid cell lines by peripheral blood leukocytes taken from patients with acute infectious mononucleosis.
Hutt L.M., Huang Y.-T., Dascomb H.E., Pagano J.S.
J. Immunol. 115:243-248(1975).
Sensitivity of the Epstein-Barr virus transformed human lymphoid cell lines to interferon.
Adams A., Strander H., Cantell K.
J. Gen. Virol. 28:207-217(1975).
Differences in the ability of human lymphoblastoid lines to exclude bromodeoxyuridine and in their sensitivity to methyl methanesulfonate and to incorporated [3H]thymidine.
Higgins N.P., Strauss B.S.
Cancer Res. 39:312-320(1979).
Detection of T-cell lymphoma-associated antigens on cord blood lymphocytes and phytohemagglutinin-stimulated blasts.
Kaplan J., Peterson W.D. Jr.
Cancer Res. 36:3471-3475(1976).
Human B-cell interleukin-10: B-cell lines derived from patients with acquired immunodeficiency syndrome and Burkitt's lymphoma constitutively secrete large quantities of interleukin-10.
Benjamin D., Knobloch T.J., Dayton M.A.
Blood 80:1289-1298(1992).
p53 is frequently mutated in Burkitt's lymphoma cell lines.";
Farrell P.J., Allan G.J., Shanahan F., Vousden K.H., Crook T.
EMBO J. 10:2879-2887(1991).
Expression of leukocyte common antigen (CD45) on various human leukemia/lymphoma cell lines.
Nakano A., Harada T., Morikawa S., Kato Y.
Acta Pathol. Jpn. 40:107-115(1990).
Identification of a human transcription unit affected by the variant chromosomal translocations 2;8 and 8;22 of Burkitt lymphoma.
Shtivelman E., Henglein B., Groitl P., Lipp M., Bishop J.M.
Proc. Natl. Acad. Sci. U.S.A. 86:3257-3260(1989).
Isoenzyme studies in human leukemia-lymphoma cell lines -- 1. carboxylic esterase.
Drexler H.G., Gaedicke G., Minowada J.
Leuk. Res. 9:209-229(1985).
The cytogenetics of human B lymphoid malignancy: studies in Burkitt's lymphoma and Epstein-Barr virus-transformed lymphoblastoid cell lines.
Steel C.M., Morten J.E.N., Foster E.
IARC Sci. Publ. 60:265-292(1985).
Expression of B-cell-specific markers in different Burkitt lymphoma subgroups.
Ehlin-Henriksson B., Manneborg-Sandlund A., Klein G.
Int. J. Cancer 39:211-218(1987).
c-yes and bcl-2 genes located on 18q21.3 in a follicular lymphoma cell line carrying a t(14;18) chromosomal translocation.
Uchino H., Toyoshima K.
Int. J. Cancer 39:785-788(1987).
Expression of surface antigens during the cell cycle in different growth phases of American and African Burkitt's lymphoma cell lines.
Sieverts H., Alabaster O., Goldschmidts W., Magrath I.T.
Cancer Res. 46:1182-1188(1986).
Heterogeneity of B-cell growth factor receptor reactivity in healthy donors and in patients with chronic lymphatic leukemia: relationship to B-cell-derived lymphokines.
Benjamin D., Bazar L.S., Wallace B., Jacobson R.J.
Cell. Immunol. 103:394-408(1986).
Isoenzyme studies in human leukemia-lymphoma cell lines -- III. Beta-hexosaminidase (E.C. 3.2.1.30).
Drexler H.G., Gaedicke G., Minowada J.
Leuk. Res. 9:549-559(1985).
Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid phosphatase.
Drexler H.G., Gaedicke G., Minowada J.
Leuk. Res. 9:537-548(1985).
Immunophenotypic classification of 28 Burkitt cell lines with monoclonal antibodies and reagent selection for bone-marrow purging.
Dore J.-F., Lenoir G.M.
IARC Sci. Publ. 60:447-452(1985).
Sensitivity of Epstein-Barr virus (EBV) producer and non-producer human lymphoblastoid cell lines to superinfection with EB-virus.
Klein G., Dombos L., Gothoskar B.
Int. J. Cancer 10:44-57(1972).
Membrane immunofluorescence reactions of Burkitt lymphoma cells from biopsy specimens and tissue cultures.
Kourilsky F.M., Burchenal J.H.
J. Natl. Cancer Inst. 39:1027-1044(1967).
Studies on the infectivity and cytopathology of Epstein-Barr virus in human lymphoblastoid cells.
Durr F.E., Monroe J.H., Schmitter R., Traul K.A., Hirshaut Y.
Int. J. Cancer 6:436-449(1970).
Incidence of EB virus-containing cells in primary and secondary clones of several Burkitt lymphoma cell lines.
Maurer B.A., Imamura T., Wilbert S.M.
Cancer Res. 30:2870-2875(1970).
Production of antigens associated with Epstein-Barr virus in experimentally infected lymphoblastoid cell lines.
Pearson G.R., Henle G.S., Henle W.
J. Natl. Cancer Inst. 46:1243-1250(1971).
Radioiodine-labeled antibody test for the detection of membrane antigens associated with Epstein-Barr virus.
Hewetson J.F., Gothoskar B., Klein G.
J. Natl. Cancer Inst. 48:87-94(1972).
Relationship between the sensitivity of EBV-carrying lymphoblastoid lines to superinfection and the inducibility of the resident viral genome.
Klein G., Dombos L.
Int. J. Cancer 11:327-337(1973).
The presence of the Epstein-Barr viral genome in human lymphoblastoid B-cell lines and its absence in a myeloma cell line.
Minowada J., Nonoyama M., Moore G.E., Rauch A.M., Pagano J.S.
Cancer Res. 34:1898-1903(1974).
Synthesis of Epstein-Barr virus after activation of the viral genome in a 'virus-negative' human lymphoblastoid cell (Raji) made resistant to 5-bromodeoxyuridine.
Hampar B., Derge J.G., Martos L.M., Walker J.L.
Proc. Natl. Acad. Sci. U.S.A. 69:78-82(1972).
Genetic studies on human lymphoblastoid lines: isozyme analysis on cell lines from forty-one different individuals and on mutants produced following exposure to a chemical mutagen.
Steel C.M., Blenkinsop C., Evans H.J.
Ann. Hum. Genet. 36:247-266(1973).
Heterotransplantability of human cell lines derived from leukemia and lymphomas into immunologically tolerant rats.
McComb V.
Cancer 24:211-222(1969).
Chromosome studies of 8 in vitro lines of Burkitt's lymphoma.";
Miles C.P., O'Neill F.
Cancer Res. 27:392-402(1967).
Distinction between Burkitt lymphoma subgroups by monoclonal antibodies: relationships between antigen expression and type of chromosomal translocation.
Ehlin-Henriksson B., Klein G.
Int. J. Cancer 33:459-463(1984).
Examination of Epstein-Barr virus and C-type proviral sequences in American and African lymphomas and derivative cell lines.
Sherrick D., Gray T.E.
Cancer Res. 41:3165-3171(1981).
Immunoglobulin secretion by cell lines derived from African and American undifferentiated lymphomas of Burkitt's and non-Burkitt's type.
Parsons R.G.
J. Immunol. 129:1336-1342(1982).
Translocation joins c-myc and immunoglobulin gamma 1 genes in a Burkitt lymphoma revealing a third exon in the c-myc oncogene.
Hamlyn P.H., Rabbitts T.H.
Nature 304:135-139(1983).
Altered nucleotide sequences of a translocated c-myc gene in Burkitt lymphoma.
Rabbitts T.H., Hamlyn P.H., Baer R.
Nature 306:760-765(1983).
Relationship between karyotype of tissue culture lines and tumorigenicity in nude mice.
Gershwin M.E., Lentz D., Owens R.B.
Exp. Cell Biol. 52:361-370(1984).
Effect of somatic mutation within translocated c-myc genes in Burkitt's lymphoma.
Rabbitts T.H., Forster A., Hamlyn P.H., Baer R.
Nature 309:592-597(1984).