SG231Homo sapiens (Human)Cancer cell line
Also known as: PCI:SG-231, PCI-SG231, PCI:SG231
🤖 AI SummaryBased on 2 publications
Quick Overview
Human intrahepatic cholangiocarcinoma cell line with IDH mutations and SRC dependence.
Detailed Summary
SG231 is a human intrahepatic cholangiocarcinoma cell line derived from a 42-year-old male patient with metastatic cholangiocarcinoma. The cell line exhibits a highly aneuploid karyotype with complex chromosomal rearrangements, including multiple marker chromosomes and double-minute chromosomes. SG231 shows hypersensitivity to dasatinib, a multi-kinase inhibitor, due to its dependency on SRC signaling for survival and proliferation. This cell line is tumorigenic in immunosuppressed nude mice and maintains characteristics of biliary epithelium, including expression of keratins and absence of Factor VIII antigen. It is used for studying the genetic and molecular mechanisms of cholangiocarcinoma, particularly focusing on IDH mutations and their implications in drug sensitivity.
Research Applications
Drug sensitivity profilingSRC signaling dependencyIDH mutation analysisTumorigenicity in vivo
Key Characteristics
Highly aneuploid karyotypeHypersensitivity to dasatinibTumorigenic in nude miceBiliary epithelial markers expression
Generated on 6/15/2025
Basic Information
| Database ID | CVCL_0519 |
|---|---|
| Species | Homo sapiens (Human) |
Donor Information
| Age | 42 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Cholangiocarcinoma |
|---|---|
| Lineage | Biliary Tract |
| Subtype | Intrahepatic Cholangiocarcinoma |
| OncoTree Code | IHCH |
DepMap Information
| Source Type | Academic lab |
|---|---|
| Source ID | ACH-001857_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Thr125Pro (c.373A>C) | Unspecified | - | Unknown |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
10
D13S317
9,10
D16S539
9,14
D18S51
18
D21S11
29
D3S1358
17
D5S818
12
D7S820
11
D8S1179
12,13
FGA
21,21.2
Penta D
12,15
Penta E
10,13
TH01
8,9
TPOX
8,11
vWA
16
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Generation of a biliary tract cancer cell line atlas reveals molecular subtypes and therapeutic targets.
Vazquez F., Getz G., Bardeesy N.M.
bioRxiv 2024:07.04.601970-07.04.601970(2024).
Development and characterization of human primary cholangiocarcinoma cell lines.
Glaser S., Kennedy L., Francis H., Zhang W.-J., Alpini G.D., Ekser B.
Am. J. Pathol. 192:1200-1217(2022).
Isocitrate dehydrogenase mutations confer dasatinib hypersensitivity and SRC dependence in intrahepatic cholangiocarcinoma.
Bardeesy N.M.
Cancer Discov. 6:727-739(2016).