SK-N-BE(2)Homo sapiens (Human)Cancer cell line
Also known as: SKNBE, SK-N-BE, SKNBE2, SKNBE-2, SKNBE(2), SK-N-BE-2, SK-N-BE2
Quick Overview
Human neuroblastoma cell line with MYCN amplification and chromosomal abnormalities.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_0528 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Bone marrow[UBERON:UBERON_0002371] |
Donor Information
| Age | 2 |
|---|---|
| Age Category | Pediatric |
| Sex | Male |
| Subtype Features | MYC_Amplified |
Disease Information
| Disease | Neuroblastoma |
|---|---|
| Lineage | Peripheral Nervous System |
| Subtype | Neuroblastoma |
| OncoTree Code | NBL |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-000312_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Cys135Phe (c.404G>T) | Heterozygous | - | PubMed=22170099, PubMed=19147553, PubMed=16142320 |
| Gene deletion | TP53 | - | Homozygous | 2 out of 3 copies | from parent cell line HL-60 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Transcriptomic profiling of 39 commonly-used neuroblastoma cell lines.
Hart L.S., Dent M.H., Fortina P., Reynolds C.P., Maris J.M.
Sci. Data 4:170033-170033(2017).
Neuroblastoma tyrosine kinase signaling networks involve FYN and LYN in endosomes and lipid rafts.
George L., Comb M.J., Grimes M.L.
PLoS Comput. Biol. 11:e1004130.1-e1004130.33(2015).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
Alternative lengthening of telomeres in neuroblastoma cell lines is associated with a lack of MYCN genomic amplification and with p53 pathway aberrations.
Lau L.M.S.
J. Neurooncol. 119:17-26(2014).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma.
Opoku-Ansah J., Wada R.K., Bachmann A.S., Ramos J.W.
Int. J. Cancer 131:1556-1568(2012).
NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome.
Messiaen L.M., Versteeg R., Bernards R.
Cell 142:218-229(2010).
Gene amplification as double minutes or homogeneously staining regions in solid tumors: origin and structure.
Rocchi M.
Genome Res. 20:1198-1206(2010).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Mutations in PIK3CA are infrequent in neuroblastoma.";
Dam V., Morgan B.T., Mazanek P., Hogarty M.D.
BMC Cancer 6:177.1-177.10(2006).
High-resolution detection and mapping of genomic DNA alterations in neuroblastoma.
Maris J.M.
Genes Chromosomes Cancer 43:390-403(2005).
Characteristics of stem cells from human neuroblastoma cell lines and in tumors.
Biedler J.L., Cheung N.-K.V., Ross R.A.
Neoplasia 6:838-845(2004).
Combined M-FISH and CGH analysis allows comprehensive description of genetic alterations in neuroblastoma cell lines.
Salwen H.R., Laureys G., Manoel N., De Paepe A., Speleman F.
Genes Chromosomes Cancer 32:126-135(2001).
Loss of p53 function confers high-level multidrug resistance in neuroblastoma cell lines.
Gomer C.J., Triche T.J., Reynolds C.P.
Cancer Res. 61:6185-6193(2001).
Deletion mapping in neuroblastoma cell lines suggests two distinct tumor suppressor genes in the 1p35-36 region, only one of which is associated with N-myc amplification.
Speleman F., Versteeg R.
Oncogene 10:291-297(1995).
Cell surface antigens of human ovarian and endometrial carcinoma defined by mouse monoclonal antibodies.
Mattes M.J., Cordon-Cardo C., Lewis J.L. Jr., Old L.J., Lloyd K.O.
Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984).
Phenotypic diversification in human neuroblastoma cells: expression of distinct neural crest lineages.
Ciccarone V.C., Spengler B.A., Meyers M.B., Biedler J.L., Ross R.A.
Cancer Res. 49:219-225(1989).
A novel chromosome abnormality in human neuroblastoma and antifolate-resistant Chinese hamster cell lives in culture.
Biedler J.L., Spengler B.A.
J. Natl. Cancer Inst. 57:683-695(1976).
Multiple neurotransmitter synthesis by human neuroblastoma cell lines and clones.
Biedler J.L., Roffler-Tarlov S., Schachner M., Freedman L.S.
Cancer Res. 38:3751-3757(1978).
Tumor cell lines of the peripheral nervous system.";
Israel M.A., Thiele C.J.
(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.43-78; Academic Press; New York; USA (1994).
Homogeneously staining regions and double minute chromosomes, prevalent cytogenetic abnormalities of human neuroblastoma cells.
Biedler J.L., Meyers M.B., Spengler B.A.
(In book chapter) Advances in cellular neurobiology, Vol. 4; Fedoroff S., Hertz L. (eds.); pp.267-307; Academic Press; New York; USA (1983).
Chromosome abnormalities in human tumor cells in culture.";
Biedler J.L.
(In book chapter) Human tumor cells in vitro; Fogh J. (eds.); pp.359-394; Springer; New York; USA (1975).
Neuroblastoma.";
Thiele C.J.
(In book chapter) Human cell culture. Vol. 1. Cancer cell lines part 1; Masters J.R.W., Palsson B.O. (eds.); pp.21-53; Kluwer Academic Publishers; New York; USA (1999).