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SK-UT-1Homo sapiens (Human)Cancer cell line

Also known as: Skut1, SKUT1, SKUT-1, SK UT 1

🤖 AI SummaryBased on 11 publications

Quick Overview

Human uterine leiomyosarcoma cell line for cancer research.

Detailed Summary

The SK-UT-1 cell line is a human uterine leiomyosarcoma cell line derived from a primary tumor. It is widely used in cancer research for studying the molecular mechanisms of sarcomas and evaluating drug responses. This cell line has been characterized in multiple studies, including its genetic profile, sensitivity to various anticancer agents, and its utility in understanding tumor biology. Research involving SK-UT-1 has contributed to identifying potential therapeutic targets and biomarkers for sarcoma treatment. The cell line is also utilized in studies related to cell surface antigens and their role in cancer progression.

Research Applications

Cancer researchDrug sensitivity profilingMolecular mechanism studiesTherapeutic target identification

Key Characteristics

Uterine originLeiomyosarcomaUsed in drug response studies

Generated on 6/15/2025

Basic Information

Database ID	CVCL_0533
Species	Homo sapiens (Human)
Tissue Source	Uterus[UBERON:UBERON_0000995]

Donor Information

Age	75
Age Category	Adult
Sex	Female
Race	caucasian

Disease Information

Disease	Leiomyosarcoma of the corpus uteri
Lineage	Uterus
Subtype	Uterine Leiomyosarcoma
OncoTree Code	ULMS

DepMap Information

Source Type	ATCC
Source ID	ACH-000939_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg248Gln (c.743G>A)	Unspecified	Somatic mutation acquired during proliferation	PubMed=20575032
MutationSimple	TP53	p.Arg175His (c.524G>A)	Unspecified	Somatic mutation acquired during proliferation	from parent cell line YCC-3
MutationSimple	RB1	p.Val654Cysfs*4 (c.1959delA)	Homozygous	-	from parent cell line SK-UT-1
MutationSimple	PTEN	p.Asn323fs*2 (c.968_969insA)	Heterozygous	-	from parent cell line SK-UT-1
MutationSimple	PTEN	p.Thr319fs1 (c.955_958delACTT) (p.VL317fs) (V317fs3)	Heterozygous	-	from parent cell line SK-UT-1
MutationSimple	PIK3CA	p.Arg88Gln (c.263G>A)	Heterozygous	-	Unknown, Unknown
MutationSimple	APC	p.Thr1556Leufs*9 (c.4666delA)	Heterozygous	-	from parent cell line SK-OV-3
MutationSimple	APC	p.Gln1096Ter (c.3286C>T)	Heterozygous	-	from parent cell line SK-UT-1

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

10,11

D13S317

13

D16S539

13,14

D18S51

11,16

D19S433

12,13

D21S11

29,32.2

D2S1338

18,19,21

D3S1358

15,16

D5S818

10,11

D7S820

9,10

D8S1179

13,15

FGA

22,24

Penta D

11,14,15

Penta E

17

TH01

7

TPOX

8

vWA

15,16

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Sister chromatid exchange and genomic instability in soft tissue sarcomas: potential implications for response to DNA-damaging treatments.

Salawu A., Wright K., Al-Kathiri A., Wyld L., Reed M.W.R., Sisley K.

Sarcoma 2018:3082526.1-3082526.8(2018).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.

Harris E., Monks A., Morris J.

Mol. Cancer Ther. 14:2452-2462(2015).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

Presence of glycogen and growth-related variations in 58 cultured human tumor cell lines of various tissue origins.

Rousset M., Zweibaum A., Fogh J.

Cancer Res. 41:1165-1170(1981).

Distinction of seventy-one cultured human tumor cell lines by polymorphic enzyme analysis.

Wright W.C., Daniels W.P., Fogh J.

J. Natl. Cancer Inst. 66:239-247(1981).

Cell surface antigens of human ovarian and endometrial carcinoma defined by mouse monoclonal antibodies.

Mattes M.J., Cordon-Cardo C., Lewis J.L. Jr., Old L.J., Lloyd K.O.

Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984).

Human tumor lines for cancer research.";

Fogh J.

Cancer Invest. 4:157-184(1986).

Mutation of the p53 gene in human soft tissue sarcomas: association with abnormalities of the RB1 gene.

Fletcher C.D.M., Ball A.B.S., Thomas M., Gusterson B.A., Cooper C.S.

Oncogene 5:1297-1301(1990).

Absence of HeLa cell contamination in 169 cell lines derived from human tumors.

Fogh J., Wright W.C., Loveless J.D.

J. Natl. Cancer Inst. 58:209-214(1977).

One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.

Fogh J., Fogh J.M., Orfeo T.

J. Natl. Cancer Inst. 59:221-226(1977).

New human tumor cell lines.";

Fogh J., Trempe G.L.

(In book chapter) Human tumor cells in vitro; Fogh J. (eds.); pp.115-159; Springer; New York; USA (1975).

Web Resources

thermofisher.com mskcc.org