SU-DHL-1Homo sapiens (Human)Cancer cell line
Also known as: SU-DHL1, SUDHL1, SUDHL-1, SuDHL-1, SuDHL 1, Stanford University-Diffuse Histiocytic Lymphoma-1
Quick Overview
SU-DHL-1 is a human anaplastic large cell lymphoma cell line derived from pleural effusion, characterized by the presence of th...
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_0538 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Pleural effusion[UBERON:UBERON_0000175] |
Donor Information
| Age | 10 |
|---|---|
| Age Category | Pediatric |
| Sex | Male |
Disease Information
| Disease | Anaplastic large cell lymphoma, ALK-positive |
|---|---|
| Lineage | Lymphoid |
| Subtype | Anaplastic Large-Cell Lymphoma ALK Positive |
| OncoTree Code | ALCLALKP |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-000664_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| Gene fusion | ALK | NPM1-ALK | - | - | PubMed=9121481, PubMed=7824924 |
| MutationSimple | TP53 | p.Arg273His (c.818G>A) | Homozygous | - | Unknown, PubMed=16264262 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
The leukemia-lymphoma cell line factsbook.";
Drexler H.G.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
Heterogeneity of cellular origins in human malignant lymphoma cell line derived from histo-monocytic lineage cells.
Morikawa S., Harada T., Katoh T.
(In book chapter) Cellular, molecular, genetic approaches to immunodiagnosis and immunotherapy. 8th International conference on labeled antibodies, Tokyo, November 1985; Kano K., Mori S., Sugisaki T., Torisu M. (eds.); pp.373-380; Karger; Basel; Switzerland (1988).
Biology and virology of the human malignant lymphomas: 1st Milford D. Schulz Lecture.
Kaplan H.S., Goodenow R.S., Gartner S., Bieber M.M.
Cancer 43:1-24(1979).
Biology of the human malignant lymphomas. IV. Functional characterization of ten diffuse histiocytic lymphoma cell lines.
Epstein A.L., Levy R., Kim H., Henle W., Henle G.S., Kaplan H.S.
Cancer 42:2379-2391(1978).
Feeder layer and nutritional requirements for the establishment and cloning of human malignant lymphoma cell lines.
Epstein A.L., Kaplan H.S.
Cancer Res. 39:1748-1759(1979).
Lack of involvement of the c-fms and N-myc genes by chromosomal translocation t(2;5)(p23;q35) common to malignancies with features of so-called malignant histiocytosis.
Mellentin J.D., Warnke R.A., Cleary M.L.
Blood 73:2155-2164(1989).
Isoenzyme studies in human leukemia-lymphoma cell lines -- 1. carboxylic esterase.
Drexler H.G., Gaedicke G., Minowada J.
Leuk. Res. 9:209-229(1985).
Isoenzyme studies in human leukemia-lymphoma cell lines -- III. Beta-hexosaminidase (E.C. 3.2.1.30).
Drexler H.G., Gaedicke G., Minowada J.
Leuk. Res. 9:549-559(1985).
Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid phosphatase.
Drexler H.G., Gaedicke G., Minowada J.
Leuk. Res. 9:537-548(1985).
Histiocytic lymphoma cell lines: immunologic and cytogenetic studies.
Hecht F.
Cancer Genet. Cytogenet. 14:205-218(1985).
Biology of the human malignant lymphomas. I. Establishment in continuous cell culture and heterotransplantation of diffuse histiocytic lymphomas.
Epstein A.L., Kaplan H.S.
Cancer 34:1851-1872(1974).
Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma.
Look A.T., Saltman D.L.
Science 267:316-317(1995).
Homozygous loss of the MTS1/p16 and MTS2/p15 genes in lymphoma and lymphoblastic leukaemia cell lines.
Uppenkamp M.J., Nowrousian M.R., Seeber S., Opalka B.
Br. J. Haematol. 91:350-354(1995).
The (2;5)(p23;q35) translocation in cell lines derived from malignant lymphomas: absence of t(2;5) in Hodgkin-analogous cell lines.
Quentmeier H., Drexler H.G.
Leukemia 10:142-149(1996).
Role of the nucleophosmin (NPM) portion of the non-Hodgkin's lymphoma-associated NPM-anaplastic lymphoma kinase fusion protein in oncogenesis.
Bischof D., Pulford K., Mason D.Y., Morris S.W.
Mol. Cell. Biol. 17:2312-2325(1997).
Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia.
Aizawa Y., Ueda R., Seto M.
Jpn. J. Cancer Res. 89:712-718(1998).
Biological significance of the expression of HIV-related chemokine coreceptors (CCR5 and CXCR4) and their ligands by human hematopoietic cell lines.
Gaulton G.N., Ratajczak M.Z.
Leukemia 14:1821-1832(2000).
Biochemical differences between SUDHL-1 and KARPAS 299 cells derived from t(2;5)-positive anaplastic large cell lymphoma are responsible for the different sensitivity to the antiproliferative effect of p27(Kip1).
Turturro F., Frist A.Y., Arnold M.D., Seth P., Pulford K.
Oncogene 20:4466-4475(2001).
Malignant hematopoietic cell lines: in vitro models for the study of anaplastic large-cell lymphoma.
Drexler H.G., MacLeod R.A.F.
Leukemia 18:1569-1571(2004).
Proteomic analysis of anaplastic lymphoma cell lines: identification of potential tumour markers.
Monsarrat B., Delsol G., Payrastre B.
Proteomics 6:3210-3222(2006).
Human T-cell lines with well-defined T-cell receptor gene rearrangements as controls for the BIOMED-2 multiplex polymerase chain reaction tubes.
Langerak A.W.
Leukemia 21:230-237(2007).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
National Cancer Institute pediatric preclinical testing program: model description for in vitro cytotoxicity testing.
Reynolds C.P.
Pediatr. Blood Cancer 56:239-249(2011).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
High-throughput RNA sequencing-based virome analysis of 50 lymphoma cell lines from the Cancer Cell Line Encyclopedia project.
O'Grady T., Baddoo M., Fewell C., Renne R., Flemington E.K.
J. Virol. 89:713-729(2015).
A comprehensive transcriptional portrait of human cancer cell lines.
Settleman J., Seshagiri S., Zhang Z.-M.
Nat. Biotechnol. 33:306-312(2015).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
Excess of NPM-ALK oncogenic signaling promotes cellular apoptosis and drug dependency.
Turner S.D., Gambacorti-Passerini C., Chiarle R., Voena C.
Oncogene 35:3854-3865(2016).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
Characterization and diagnostic application of genomic NPM-ALK fusion sequences in anaplastic large-cell lymphoma.
Zimmermann M., Singh V.K., Metzler M., Damm-Welk C.
Oncotarget 9:26543-26555(2018).
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
Yang H.H., Koeffler H.P.
BMC Cancer 18:940.1-940.13(2018).
Screening human cell lines for viral infections applying RNA-Seq data analysis.
Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.
PLoS ONE 14:E0210404-E0210404(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
The LL-100 panel: 100 cell lines for blood cancer studies.";
MacLeod R.A.F., Nagel S., Steube K.G., Uphoff C.C., Drexler H.G.
Sci. Rep. 9:8218-8218(2019).