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SW1116Homo sapiens (Human)Cancer cell line

Also known as: SW-1116, SW 1116, SW116

🤖 AI SummaryBased on 18 publications

Quick Overview

Human colorectal cancer cell line with known genetic and molecular characteristics.

Detailed Summary

SW1116 is a human colorectal cancer cell line derived from a colon tumor. It is widely used in research due to its well-characterized genetic and molecular features. Studies have shown that SW1116 exhibits specific mutations and alterations in key oncogenes and tumor suppressor genes, making it a valuable model for studying colorectal cancer biology and therapeutic responses. The cell line has been utilized in investigations related to drug sensitivity, genetic instability, and molecular pathways involved in tumor progression. Its consistent behavior in in vitro and in vivo models makes it a reliable tool for preclinical studies.

Research Applications

Genetic and molecular characterizationDrug sensitivity and resistance studiesTumor progression and metastasis researchMolecular pathway analysis

Key Characteristics

Mutations in key oncogenes and tumor suppressor genesGenomic instabilityConsistent in vitro and in vivo behaviorRelevance to colorectal cancer biology
Generated on 6/15/2025

Basic Information

Database IDCVCL_0544
SpeciesHomo sapiens (Human)
Tissue SourceColon[UBERON:UBERON_0001155]

Donor Information

Age73
Age CategoryAdult
SexMale
Racecaucasian

Disease Information

DiseaseColon adenocarcinoma
LineageBowel
SubtypeColon Adenocarcinoma
OncoTree CodeCOAD

DepMap Information

Source TypeATCC
Source IDACH-000489_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleAPCp.Gln264Ter (c.790C>T)Heterozygous-Unknown, PubMed=24755471
MutationSimpleAPCp.Gln1429fs*41 (c.4287_4296delAACCATGCCA)Heterozygous-Unknown, PubMed=24755471
MutationSimpleKRASp.Gly12Ala (c.35G>C)Unspecified-PubMed=21173094
MutationSimpleTP53p.Ala159Asp (c.476C>A)Homozygous-PubMed=28683746, PubMed=24755471, PubMed=24042735, PubMed=16418264, PubMed=9000147, PubMed=7651727

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X,Y
CSF1PO
10,11
D13S317
11,14
D16S539
9,12
D18S51
13
D21S11
28,29
D3S1358
16
D5S818
11,12
D7S820
11,12
D8S1179
10,11
FGA
21,22
Penta D
11,13
Penta E
10,12
TH01
6
TPOX
8,11
vWA
14,19
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

Colorectal carcinoma-specific antigen: detection by means of monoclonal antibodies.

Herlyn M., Steplewski Z., Herlyn D., Koprowski H.

Proc. Natl. Acad. Sci. U.S.A. 76:1438-1442(1979).

DOIPubMedPMC

Analysis of established human carcinoma cell lines for lymphoreticular-associated membrane receptors.

Kerbel R.S., Pross H.F., Leibovitz A.

Int. J. Cancer 20:673-679(1977).

DOIPubMed

Classification of human colorectal adenocarcinoma cell lines.";

Mabry N.D.

Cancer Res. 36:4562-4569(1976).

PubMed

Aberrant elevation of tyrosine-specific phosphorylation in human gastric cancer cells.

Ohnishi Y., Xiao H.-Y., Nagai Y., Takagi H.

Jpn. J. Cancer Res. 82:1428-1435(1991).

DOIPubMedPMC

Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.

Fine D.L., Abbott B.J., Mayo J.G., Shoemaker R.H., Boyd M.R.

Cancer Res. 48:589-601(1988).

PubMed

Epithelial polarity, villin expression, and enterocytic differentiation of cultured human colon carcinoma cells: a survey of twenty cell lines.

Chantret I., Barbat A., Dussaulx E., Brattain M.G., Zweibaum A.

Cancer Res. 48:1936-1942(1988).

PubMed

Human tumor lines for cancer research.";

Fogh J.

Cancer Invest. 4:157-184(1986).

DOIPubMed

Distinction of seventy-one cultured human tumor cell lines by polymorphic enzyme analysis.

Wright W.C., Daniels W.P., Fogh J.

J. Natl. Cancer Inst. 66:239-247(1981).

DOIPubMed

Karyotype consistency in human colorectal carcinoma cell lines established in vitro.

Chen T.-R., Hay R.J., Macy M.L.

Cancer Genet. Cytogenet. 6:93-117(1982).

DOIPubMed

Increased incidence of p53 mutations is associated with hepatic metastasis in colorectal neoplastic progression.

Steele G., Summerhayes I.C.

Oncogene 11:647-652(1995).

PubMed

Liver metastases with 10 human colon carcinoma cell lines in nude mice and association with carcinoembryonic antigen production.

Tibbetts L.M., Doremus C.M., Tzanakakis G.N., Vezeridis M.P.

Cancer 71:315-321(1993).

DOIPubMed

Inverse correlation between RER+ status and p53 mutation in colorectal cancer cell lines.

Thomas G., Hamelin R.

Oncogene 13:2727-2730(1996).

PubMed

BAT-26, an indicator of the replication error phenotype in colorectal cancers and cell lines.

Hamelin R.

Cancer Res. 57:300-303(1997).

PubMed

Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures.

Wolf E., Gabius H.-J.

J. Cancer Res. Clin. Oncol. 127:375-386(2001).

DOIPubMed

Extensive characterization of genetic alterations in a series of human colorectal cancer cell lines.

Hamelin R.

Oncogene 20:5025-5032(2001).

DOIPubMed

Mutations of the BRAF gene in human cancer.";

Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.

Nature 417:949-954(2002).

DOIPubMed

Analysis of p53 mutations and their expression in 56 colorectal cancer cell lines.

Liu Y., Bodmer W.F.

Proc. Natl. Acad. Sci. U.S.A. 103:976-981(2006).

DOIPubMedPMC

Identification by real-time PCR of 13 mature microRNAs differentially expressed in colorectal cancer and non-tumoral tissues.

Garcia-Foncillas J.

Mol. Cancer 5:29.1-29.10(2006).

DOIPubMedPMC

Cell growth, global phosphotyrosine elevation, and c-Met phosphorylation through Src family kinases in colorectal cancer cells.

Emaduddin M., Bicknell D.C., Bodmer W.F., Feller S.M.

Proc. Natl. Acad. Sci. U.S.A. 105:2358-2362(2008).

DOIPubMedPMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOIPubMedPMC

Genomic and biological characterization of exon 4 KRAS mutations in human cancer.

Lash A., Ladanyi M., Saltz L.B., Heguy A., Paty P.B., Solit D.B.

Cancer Res. 70:5901-5911(2010).

DOIPubMedPMC

5-fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency.

Bracht K., Nicholls A.M., Liu Y., Bodmer W.F.

Br. J. Cancer 103:340-346(2010).

DOIPubMedPMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOIPubMedPMC

Identification of a microRNA expression signature for chemoradiosensitivity of colorectal cancer cells, involving miRNAs-320a, -224, -132 and let7g.

Grade M., Gaedcke J.

Radiother. Oncol. 108:451-457(2013).

DOIPubMed

Epigenetic and genetic features of 24 colon cancer cell lines.";

Hektoen M., Lind G.E., Lothe R.A.

Oncogenesis 2:e71.1-e71.8(2013).

DOIPubMedPMC

Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer.

Mariadason J.M., Sieber O.M.

Cancer Res. 74:3238-3247(2014).

DOIPubMed

Comprehensive glycomics comparison between colon cancer cell cultures and tumours: implications for biomarker studies.

Molloy M.P., Packer N.H.

J. Proteomics 108:146-162(2014).

DOIPubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOIPubMed

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOIPubMed

The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.

Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.

Nat. Commun. 6:7002.1-7002.10(2015).

DOIPubMed

Highly expressed genes in rapidly proliferating tumor cells as new targets for colorectal cancer treatment.

Sanchez A., Schwartz S. Jr., Bilic J., Mariadason J.M., Arango D.

Clin. Cancer Res. 21:3695-3704(2015).

DOIPubMed

N-glycosylation profiling of colorectal cancer cell lines reveals association of fucosylation with differentiation and caudal type homebox 1 (CDX1)/villin mRNA expression.

Tollenaar R.A.E.M., Rombouts Y., Wuhrer M.

Mol. Cell. Proteomics 15:124-140(2016).

DOIPubMedPMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOIPubMedPMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOIPubMedPMC

Multi-omics of 34 colorectal cancer cell lines -- a resource for biomedical studies.

Myklebost O., Skotheim R.I., Sveen A., Lothe R.A.

Mol. Cancer 16:116.1-116.16(2017).

DOIPubMedPMC

Genomic determinants of protein abundance variation in colorectal cancer cells.

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Choudhary J.S.

Cell Rep. 20:2201-2214(2017).

DOIPubMedPMC

Pharmacoproteomic characterisation of human colon and rectal cancer.

Weichert W., Knapp S., Feller S.M., Kuster B.

Mol. Syst. Biol. 13:951-951(2017).

DOIPubMedPMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOIPubMedPMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOIPubMedPMC

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOIPubMedPMC