SW480Homo sapiens (Human)Cancer cell line
Also known as: SW-480, SW 480, SW480E, SWH80, SW80 (Occasionally.), WE480 (Occasionally.), WE-480 (Occasionally.)
Quick Overview
Human colorectal cancer cell line with KRAS mutation
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_0546 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Colon[UBERON:UBERON_0001155] |
Donor Information
| Age | 51 |
|---|---|
| Age Category | Adult |
| Sex | Male |
| Race | caucasian |
Disease Information
| Disease | Colon adenocarcinoma |
|---|---|
| Lineage | Bowel |
| Subtype | Colon Adenocarcinoma |
| OncoTree Code | COAD |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-000842_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | APC | p.Gln1338Ter (c.4012C>T) | Homozygous | - | from parent cell line SW620 |
| MutationSimple | KRAS | p.Gly12Val (c.35G>T) | Heterozygous | Acquired | Unknown, Unknown |
| MutationSimple | TP53 | p.Arg273His (c.818G>A) | Homozygous | - | Unknown, PubMed=16264262 |
| MutationSimple | TP53 | p.Pro309Ser (c.925C>T) | Heterozygous | - | from parent cell line SW620 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Genomic and biological characterization of exon 4 KRAS mutations in human cancer.
Lash A., Ladanyi M., Saltz L.B., Heguy A., Paty P.B., Solit D.B.
Cancer Res. 70:5901-5911(2010).
Comparison of different colorectal cancer with liver metastases models using six colorectal cancer cell lines.
Xu Y.-T., Zhang L., Wang Q.-L., Zheng M.-J.
Pathol. Oncol. Res. 26:2177-2183(2020).
Quantitative proteomics of the Cancer Cell Line Encyclopedia.";
Sellers W.R., Gygi S.P.
Cell 180:387-402.e16(2020).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
Gene expression profile of cancer stem-like cells in the SW480 colon adenocarcinoma cell line.
Wang Y.-Y., Zhou L., Qing Q., Li Y.-F., Li L.-X., Dong X.-Y., Xiao B.
Oncol. Rep. 42:386-398(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Proteomic characterization of transcription and splicing factors associated with a metastatic phenotype in colorectal cancer.
Calvino E., Fernandez-Acenero M.J., Casal J.I.
J. Proteome Res. 17:252-264(2018).
Pharmacoproteomic characterisation of human colon and rectal cancer.
Weichert W., Knapp S., Feller S.M., Kuster B.
Mol. Syst. Biol. 13:951-951(2017).
Multi-omics of 34 colorectal cancer cell lines -- a resource for biomedical studies.
Myklebost O., Skotheim R.I., Sveen A., Lothe R.A.
Mol. Cancer 16:116.1-116.16(2017).
Characterization of human cancer cell lines by reverse-phase protein arrays.
Liang H.
Cancer Cell 31:225-239(2017).
Phosphoproteomics of colon cancer metastasis: comparative mass spectrometric analysis of the isogenic primary and metastatic cell lines SW480 and SW620.
Schunter A.J., Yue X.-S., Hummon A.B.
Anal. Bioanal. Chem. 409:1749-1763(2017).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
N-glycosylation profiling of colorectal cancer cell lines reveals association of fucosylation with differentiation and caudal type homebox 1 (CDX1)/villin mRNA expression.
Tollenaar R.A.E.M., Rombouts Y., Wuhrer M.
Mol. Cell. Proteomics 15:124-140(2016).
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Golub T.R., Root D.E., Hahn W.C.
Sci. Data 1:140035-140035(2014).
Highly expressed genes in rapidly proliferating tumor cells as new targets for colorectal cancer treatment.
Sanchez A., Schwartz S. Jr., Bilic J., Mariadason J.M., Arango D.
Clin. Cancer Res. 21:3695-3704(2015).
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.
Nat. Commun. 6:7002.1-7002.10(2015).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
Feasibility of label-free phosphoproteomics and application to base-line signaling of colorectal cancer cell lines.
Pham T.V., Ishihama Y., Verheul H.M.W., Jimenez C.R.
J. Proteomics 127:247-258(2015).
A comprehensive transcriptional portrait of human cancer cell lines.
Settleman J., Seshagiri S., Zhang Z.-M.
Nat. Biotechnol. 33:306-312(2015).
Comprehensive glycomics comparison between colon cancer cell cultures and tumours: implications for biomarker studies.
Molloy M.P., Packer N.H.
J. Proteomics 108:146-162(2014).
Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer.
Mariadason J.M., Sieber O.M.
Cancer Res. 74:3238-3247(2014).
Epigenetic and genetic features of 24 colon cancer cell lines.";
Hektoen M., Lind G.E., Lothe R.A.
Oncogenesis 2:e71.1-e71.8(2013).
Identification of a microRNA expression signature for chemoradiosensitivity of colorectal cancer cells, involving miRNAs-320a, -224, -132 and let7g.
Grade M., Gaedcke J.
Radiother. Oncol. 108:451-457(2013).
Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines.
Orphanides G., French T., Wessels L.F.A.
BMC Med. Genomics 5:66.1-66.15(2012).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
Human embryonic stem cells and metastatic colorectal cancer cells shared the common endogenous human microRNA-26b.
Peng J.-Y., Chen H.-Q., Zhou Y.-K., Liu W.-J., Qin H.-L.
J. Cell. Mol. Med. 15:1941-1954(2011).
5-fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency.
Bracht K., Nicholls A.M., Liu Y., Bodmer W.F.
Br. J. Cancer 103:340-346(2010).
Colorectal carcinoma-specific antigen: detection by means of monoclonal antibodies.
Herlyn M., Steplewski Z., Herlyn D., Koprowski H.
Proc. Natl. Acad. Sci. U.S.A. 76:1438-1442(1979).
Detection and analysis of a glucose 6-phosphate dehydrogenase phenotype B cell line contamination.
Fogh H., Fogh J.
J. Natl. Cancer Inst. 63:635-645(1979).
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
Fogh J., Fogh J.M., Orfeo T.
J. Natl. Cancer Inst. 59:221-226(1977).
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
Fogh J., Wright W.C., Loveless J.D.
J. Natl. Cancer Inst. 58:209-214(1977).
Analysis of established human carcinoma cell lines for lymphoreticular-associated membrane receptors.
Kerbel R.S., Pross H.F., Leibovitz A.
Int. J. Cancer 20:673-679(1977).
Classification of human colorectal adenocarcinoma cell lines.";
Mabry N.D.
Cancer Res. 36:4562-4569(1976).
Growth stimulation of a human colorectal carcinoma cell line by interleukin-1 and -6 and antagonistic effects of transforming growth factor beta 1.
Lorenzoni M., Givel J.-C., Odartchenko N.
Eur. J. Cancer 28A:1894-1899(1992).
Aberrant elevation of tyrosine-specific phosphorylation in human gastric cancer cells.
Ohnishi Y., Xiao H.-Y., Nagai Y., Takagi H.
Jpn. J. Cancer Res. 82:1428-1435(1991).
Epithelial polarity, villin expression, and enterocytic differentiation of cultured human colon carcinoma cells: a survey of twenty cell lines.
Chantret I., Barbat A., Dussaulx E., Brattain M.G., Zweibaum A.
Cancer Res. 48:1936-1942(1988).
Cell surface antigens of human ovarian and endometrial carcinoma defined by mouse monoclonal antibodies.
Mattes M.J., Cordon-Cardo C., Lewis J.L. Jr., Old L.J., Lloyd K.O.
Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984).
Karyotype consistency in human colorectal carcinoma cell lines established in vitro.
Chen T.-R., Hay R.J., Macy M.L.
Cancer Genet. Cytogenet. 6:93-117(1982).
Presence of glycogen and growth-related variations in 58 cultured human tumor cell lines of various tissue origins.
Rousset M., Zweibaum A., Fogh J.
Cancer Res. 41:1165-1170(1981).
Increased incidence of p53 mutations is associated with hepatic metastasis in colorectal neoplastic progression.
Steele G., Summerhayes I.C.
Oncogene 11:647-652(1995).
Increased mutation rate at the hprt locus accompanies microsatellite instability in colon cancer.
Willson J.K.V., Veigl M.L., Sedwick W.D., Markowitz S.D.
Oncogene 10:33-37(1995).
Liver metastases with 10 human colon carcinoma cell lines in nude mice and association with carcinoembryonic antigen production.
Tibbetts L.M., Doremus C.M., Tzanakakis G.N., Vezeridis M.P.
Cancer 71:315-321(1993).
Radio-induced modulation of transforming growth factor beta1 sensitivity in a p53 wild-type human colorectal-cancer cell line.
Suardet L., Li C., Little J.B.
Int. J. Cancer 68:126-131(1996).
Inverse correlation between RER+ status and p53 mutation in colorectal cancer cell lines.
Thomas G., Hamelin R.
Oncogene 13:2727-2730(1996).
BAT-26, an indicator of the replication error phenotype in colorectal cancers and cell lines.
Hamelin R.
Cancer Res. 57:300-303(1997).
Screening the p53 status of human cell lines using a yeast functional assay.
Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Mol. Carcinog. 19:243-253(1997).
Beta-catenin mutations in cell lines established from human colorectal cancers.
Ilyas M., Tomlinson I.P.M., Rowan A.J., Pignatelli M., Bodmer W.F.
Proc. Natl. Acad. Sci. U.S.A. 94:10330-10334(1997).
Chromosome number and structure both are markedly stable in RER colorectal cancers and are not destabilized by mutation of p53.
Veigl M.L., Willson J.K.V., Schwartz S., Markowitz S.D.
Oncogene 17:719-725(1998).
Centrosome amplification and instability occurs exclusively in aneuploid, but not in diploid colorectal cancer cell lines, and correlates with numerical chromosomal aberrations.
Neumann T., Jauho A., Auer G., Ried T.
Genes Chromosomes Cancer 27:183-190(2000).
Mutations in hMSH6 alone are not sufficient to cause the microsatellite instability in colorectal cancer cell lines.
Ku J.-L., Yoon K.-A., Kim D.-Y., Park J.-G.
Eur. J. Cancer 35:1724-1729(1999).
APC mutations in sporadic colorectal tumors: a mutational 'hotspot' and interdependence of the 'two hits'.
Papadopoulou A., Bicknell D.C., Bodmer W.F., Tomlinson I.P.M.
Proc. Natl. Acad. Sci. U.S.A. 97:3352-3357(2000).
Spectral karyotyping of the human colon cancer cell lines SW480 and SW620.
Luehrs H., Scheppach W., Schmid M.
Cytogenet. Cell Genet. 88:145-152(2000).
Validation of a model of colon cancer progression.";
Tsokos M.G., Stamp G.W.H., Stetler-Stevenson W.G.
J. Pathol. 192:446-454(2000).
Spectral karyotyping suggests additional subsets of colorectal cancers characterized by pattern of chromosome rearrangement.
Bicknell D.C., Bodmer W.F., Arends M.J., Wyllie A.H., Edwards P.A.W.
Proc. Natl. Acad. Sci. U.S.A. 98:2538-2543(2001).
Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures.
Wolf E., Gabius H.-J.
J. Cancer Res. Clin. Oncol. 127:375-386(2001).
Short tandem repeat profiling provides an international reference standard for human cell lines.
Harrison M., Virmani A.K., Ward T.H., Ayres K.L., Debenham P.G.
Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001).
Extensive characterization of genetic alterations in a series of human colorectal cancer cell lines.
Hamelin R.
Oncogene 20:5025-5032(2001).
Immunocytochemical analysis of cell lines derived from solid tumors.
Quentmeier H., Osborn M., Reinhardt J., Zaborski M., Drexler H.G.
J. Histochem. Cytochem. 49:1369-1378(2001).
Analysis of p53 mutations and their expression in 56 colorectal cancer cell lines.
Liu Y., Bodmer W.F.
Proc. Natl. Acad. Sci. U.S.A. 103:976-981(2006).
Identification by real-time PCR of 13 mature microRNAs differentially expressed in colorectal cancer and non-tumoral tissues.
Garcia-Foncillas J.
Mol. Cancer 5:29.1-29.10(2006).
Definitive molecular cytogenetic characterization of 15 colorectal cancer cell lines.
Camps J., McNeil N.E., Difilippantonio M.J., Ried T.
Genes Chromosomes Cancer 49:204-223(2010).