YMB-AHomo sapiens (Human)Cancer cell line
🤖 AI SummaryBased on 1 publications
Quick Overview
Breast cancer cell line with E-cadherin and B-catenin studies.
Detailed Summary
YMB-A is a breast cancer cell line derived from YMB-1, exhibiting anchorage-dependent growth and strong cell-cell adhesion. It shows higher expression of E-cadherin and APC gene products compared to its counterpart YMB-S. Research indicates that YMB-A cells have lower levels of B-catenin and c-myc, with B-catenin localized to cell membranes, suggesting a role in maintaining cell adhesion. Inhibition of E-cadherin in YMB-A cells leads to increased nuclear B-catenin and c-myc expression, accelerating cell growth. These findings highlight YMB-A's utility in studying E-cadherin-B-catenin signaling pathways and their implications in breast cancer progression.
Research Applications
E-cadherin-B-catenin signalingBreast cancer progressionWnt-independent B-catenin-LEF/TCF signaling
Key Characteristics
Anchorage-dependent growthStrong cell-cell adhesionHigher E-cadherin and APC expressionLower B-catenin and c-myc levelsMembranous B-catenin localization
Generated on 6/15/2025
Basic Information
| Database ID | CVCL_0586 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Ascites[UBERON:UBERON_0007795] |
Disease Information
| Disease | Invasive breast carcinoma of no special type |
|---|
DepMap Information
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | PTEN | p.Leu108Arg (c.323T>G) | Homozygous | - | from parent cell line ZR-75-1 |
| MutationSimple | HRAS | p.Glu162Lys (c.484G>A) | Homozygous | - | from parent cell line ZR-75-1 |