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Kasumi-2Homo sapiens (Human)Cancer cell line

Also known as: Kasumi2, KASUMI2, KASUMI-2

🤖 AI SummaryBased on 9 publications

Quick Overview

Kasumi-2 is a human leukemia cell line derived from a patient with acute myeloid leukemia (AML-M2) with t(8;21) translocation.

Detailed Summary

Kasumi-2 is a human leukemia cell line established from a patient with acute myeloid leukemia (AML-M2) characterized by the t(8;21) translocation. This cell line is widely used in research due to its well-defined genetic features, including the RUNX1-RUNX1T1 fusion gene, which is a hallmark of AML-M2. The cell line exhibits a complex karyotype with multiple chromosomal abnormalities, including gains and losses, and has been utilized in studies investigating the molecular mechanisms of leukemogenesis and drug sensitivity. Kasumi-2 is also notable for its role in understanding the pathogenesis of AML-M2 and has been employed in preclinical studies to evaluate therapeutic strategies targeting the RUNX1-RUNX1T1 fusion protein.

Research Applications

Leukemia researchMolecular mechanisms of leukemogenesisDrug sensitivity studiesTargeted therapy development

Key Characteristics

t(8;21) translocationRUNX1-RUNX1T1 fusion geneComplex karyotypeAML-M2 classification

Generated on 6/15/2025

Basic Information

Database ID	CVCL_0590
Species	Homo sapiens (Human)
Tissue Source	Bone marrow[UBERON:UBERON_0002371]

Donor Information

Age	15
Age Category	Pediatric
Sex	Male
Subtype Features	TCF3-PBX1

Disease Information

Disease	B-lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3)
Lineage	Lymphoid
Subtype	B-Lymphoblastic Leukemia/Lymphoma with t(1;19)(q23;p13.3);TCF3-PBX1
OncoTree Code	BLLTCF3PBX1

DepMap Information

Source Type	DSMZ
Source ID	ACH-000728_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Glu11Gln (c.31G>C)	Unspecified	-	PubMed=32321971
MutationSimple	KRAS	p.Val14Leu (c.40G>T)	Heterozygous	-	Unknown
MutationSimple	HRAS	p.Gly13Ser (c.37G>A)	Heterozygous	-	Unknown
Gene fusion	PBX1	TCF3-PBX1, E2A-PBX1	-	-	PubMed=29786757

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

10,11

D13S317

8,12,13

D16S539

9,13

D18S51

12,13

D19S433

12,13

D21S11

31.2,32.2

D2S1338

17,24

D3S1358

14,16

D5S818

11,12

D7S820

11,12

D8S1179

13,14

FGA

22,23

Penta D

9,10

Penta E

11,16

TH01

8,10

TPOX

8,11

vWA

17,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines.

Lehtio J., Vesterlund M., Jafari R.

Nat. Commun. 13:1691.1-1691.19(2022).

Glucocorticoid receptor gene mutations confer glucocorticoid resistance in B-cell precursor acute lymphoblastic leukemia.

Minegishi M., Iwamoto S., Sugita K., Inukai T.

J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022).

Kasumi leukemia cell lines: characterization of tumor genomes with ethnic origin and scales of genomic alterations.

Kohara A., Kaneko Y., Kawamura M.

Hum. Cell 33:868-876(2020).

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

Copy number abnormality of acute lymphoblastic leukemia cell lines based on their genetic subtypes.

Sugita K., Hosoi H.

Int. J. Hematol. 108:312-318(2018).

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

Corrigendum to: Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines Leukemia Research 24 (2000), 255-262.

Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.

Leuk. Res. 25:275-278(2001).

Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines.

Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.

Leuk. Res. 24:255-262(2000).

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