Calu-3Homo sapiens (Human)Cancer cell line
Also known as: CALU3, Calu3, Calu 3, CALU-3, CaLu-3, CALV3
Quick Overview
Human lung adenocarcinoma cell line used in cancer research.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_0609 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Pleural effusion[UBERON:UBERON_0000175] |
Donor Information
| Age | 25 |
|---|---|
| Age Category | Adult |
| Sex | Male |
| Race | caucasian |
Disease Information
| Disease | Lung adenocarcinoma |
|---|---|
| Lineage | Lung |
| Subtype | Lung Adenocarcinoma |
| OncoTree Code | LUAD |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-000392_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Met237Ile (c.711G>T) | Unspecified | - | from parent cell line T98G |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVs.
Belouzard S., Moncorge O., Doench J.G., Goujon C.
Nat. Genet. 54:1090-1102(2022).
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Identification of cell lines CL-14, CL-40 and CAL-51 as suitable models for SARS-CoV-2 infection studies.
Safranko Z.M., Kurolt I.-C., Markotic A., Cicin-Sain L., Steenpass L.
PLoS ONE 16:E0255622-E0255622(2021).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Chemistry-first approach for nomination of personalized treatment in lung cancer.
Posner B.A., Minna J.D., Kim H.S., White M.A.
Cell 173:864-878.e29(2018).
Characterization of human cancer cell lines by reverse-phase protein arrays.
Liang H.
Cancer Cell 31:225-239(2017).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
A mass spectrometric-derived cell surface protein atlas.";
Aebersold R., Boheler K.R., Zandstra P.W., Wollscheid B.
PLoS ONE 10:E0121314-E0121314(2015).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
The characterization of the human cell line Calu-3 under different culture conditions and its use as an optimized in vitro model to investigate bronchial epithelial function.
Lanisnik Rizner T., Peternel L., Kristan K.
Eur. J. Pharm. Sci. 69:1-9(2015).
A comprehensive transcriptional portrait of human cancer cell lines.
Settleman J., Seshagiri S., Zhang Z.-M.
Nat. Biotechnol. 33:306-312(2015).
Identification of a seven glycopeptide signature for malignant pleural mesothelioma in human serum by selected reaction monitoring.
Vitek O., Felley-Bosco E., Stahel R.A., Aebersold R., Wollscheid B.
Clin. Proteomics 10:16.1-16.12(2013).
Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1.
Heymach J.V.
Cancer Discov. 2:798-811(2012).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
Prevalence of human papillomavirus 16/18/33 infection and p53 mutation in lung adenocarcinoma.
Iwakawa R., Kohno T., Enari M., Kiyono T., Yokota J.
Cancer Sci. 101:1891-1896(2010).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
Dynamic innate immune responses of human bronchial epithelial cells to severe acute respiratory syndrome-associated coronavirus infection.
Garner H.R., Peters C.J., Tseng C.-T.
PLoS ONE 5:E8729-E8729(2010).
A gene-alteration profile of human lung cancer cell lines.";
Montuenga L.M., Minna J.D., Yokota J., Sanchez-Cespedes M.
Hum. Mutat. 30:1199-1206(2009).
The SRY-HMG box gene, SOX4, is a target of gene amplification at chromosome 6p in lung cancer.
Cigudosa J.C., Lazo P.A., Sanchez-Cespedes M.
Hum. Mol. Genet. 18:1343-1352(2009).
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.
Zhou X.-M., Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.
Cell 131:1190-1203(2007).
Bexarotene (LGD1069, Targretin), a selective retinoid X receptor agonist, prevents and reverses gemcitabine resistance in NSCLC cells by modulating gene amplification.
Tooker P., Yen W.-C., Ng S.-C., Negro-Vilar A., Hermann T.W.
Cancer Res. 67:4425-4433(2007).
Established cell lines used in cystic fibrosis research.";
Gruenert D.C., Willems M., Cassiman J.-J., Frizzell R.A.
J. Cyst. Fibros. 3:191-196(2004).
Characterization of the Calu-3 cell line as a tool to screen pulmonary drug delivery.
Foster K.A., Avery M.L., Yazdanian M., Audus K.L.
Int. J. Pharm. 208:1-11(2000).
Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells.
Keith W.N., Frame M.C.
Oncogene 18:5646-5653(1999).
Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice.
Old L.J., Schreiber R.D.
Proc. Natl. Acad. Sci. U.S.A. 95:7556-7561(1998).
Calu-3: a human airway epithelial cell line that shows cAMP-dependent Cl-secretion.
Shen B.-Q., Finkbeiner W.E., Wine J.J., Mrsny R.J., Widdicombe J.H.
Am. J. Physiol. 266:L493-L501(1994).
Presence of glycogen and growth-related variations in 58 cultured human tumor cell lines of various tissue origins.
Rousset M., Zweibaum A., Fogh J.
Cancer Res. 41:1165-1170(1981).
Polymorphic enzyme analysis of cultured human tumor cell lines.";
Dracopoli N.C., Fogh J.
J. Natl. Cancer Inst. 70:469-476(1983).
Growth of cell lines and clinical specimens of human non-small cell lung cancer in a serum-free defined medium.
Brower M., Carney D.N., Oie H.K., Gazdar A.F., Minna J.D.
Cancer Res. 46:798-806(1986).
Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.
Fine D.L., Abbott B.J., Mayo J.G., Shoemaker R.H., Boyd M.R.
Cancer Res. 48:589-601(1988).
Evidence for thromboxane biosynthesis in established cell lines derived from human lung adenocarcinomas.
Hubbard W.C., Alley M.C., McLemore T.L., Boyd M.R.
Cancer Res. 48:2674-2677(1988).