Kasumi-3Homo sapiens (Human)Cancer cell line

Also known as: KASUMI3, Kasumi3, Kasumi 3, KASUMI-3, Kusami-3

🤖 AI SummaryBased on 7 publications

Quick Overview

Kasumi-3 is a human myeloblast cell line with t(3;7) and EV11 activation, used in leukemia research.

Detailed Summary

Kasumi-3 is a human leukemia cell line established from a 57-year-old male patient with myeloperoxidase-negative acute myeloid leukemia. It exhibits a unique karyotype with t(3;7)(q27;q22) and activation of the EV11 gene. The cell line is characterized by the expression of CD7, CD4, CD13, CD33, and HLA-DR, and lacks CD25 and CD41. Kasumi-3 is widely used in research on the role of the EV11 gene in leukemogenesis and has been implicated in studies of chromosomal abnormalities associated with myeloid malignancies. It is also noted for its ability to differentiate into monocytic lineage when treated with TPA, making it a valuable model for studying leukemia biology and therapeutic strategies.

Research Applications

Leukemogenesis studiesEV11 gene activation analysisChromosomal abnormality researchDifferentiation studiesTherapeutic strategy development

Key Characteristics

t(3;7)(q27;q22) chromosomal translocationEV11 gene activationCD7, CD4, CD13, CD33, HLA-DR expressionLack of CD25 and CD41Monocytic differentiation potential

Generated on 6/15/2025

Basic Information

Database ID	CVCL_0612
Species	Homo sapiens (Human)
Tissue Source	Bone marrow[UBERON:UBERON_0002371]

Donor Information

Age	57
Age Category	Adult
Sex	Male

Disease Information

Disease	Acute myeloid leukemia with minimal differentiation
Lineage	Myeloid
Subtype	AML with Minimal Differentiation
OncoTree Code	AMLMD

DepMap Information

Source Type	DSMZ
Source ID	ACH-002668_source

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

D13S317

11,12

D16S539

9,11

D18S51

14,17

D19S433

14,15

D21S11

D2S1338

18,26

D3S1358

15,16

D5S818

D7S820

10,11

D8S1179

FGA

20,24

Penta D

9,11

Penta E

TH01

6,9

TPOX

vWA

16,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Kasumi leukemia cell lines: characterization of tumor genomes with ethnic origin and scales of genomic alterations.

Kohara A., Kaneko Y., Kawamura M.

Hum. Cell 33:868-876(2020).

DOI PubMed PMC

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

DOI PubMed PMC

Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms.

Haferlach T., Shirahige K., Miyano S., Ogawa S.

Nat. Genet. 45:1232-1237(2013).

DOI PubMed

FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy.

Tsuchida M., Sugita K., Ida K., Hayashi Y.

Blood 103:1085-1088(2004).

DOI PubMed

Corrigendum to: Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines Leukemia Research 24 (2000), 255-262.

Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.

Leuk. Res. 25:275-278(2001).

DOI PubMed

Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines.

Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.

Leuk. Res. 24:255-262(2000).

DOI PubMed

Establishment of an undifferentiated leukemia cell line (Kasumi-3) with t(3;7)(q27;q22) and activation of the EVI1 gene.

Kamada N.

Jpn. J. Cancer Res. 87:269-274(1996).

DOI PubMed PMC

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

DOI

Web Resources

web.archive.org tcpaportal.org